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Suppression of a nonsense mutation in mammalian cells in vivo by the aminoglycoside anthiotics G–418 and paromomycin
Open accessAbstract
Aminoglycoside antibiotics in Escherichia coli and yeast can cause ribosomes to read through stop codons during translation. This can result in the phenotypic suppression of nonsense mutations. We show here for the first time that the aminoglycosides G-418 and paromomycin have similar effects in monkey (COS-7) cells in vivo. Suppression of an amber mutation (TAG) by aminoglycosides can restore the activity of a mutant gene transfected into COS-7 cells to almost 20% of wild type levels.
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Cited by
Neu-Yilik, G., Amthor, B., Gehring, N. H., Bahri, S., Paidassi, H., Hentze, M. W., & Kulozik, A. E. (2011) · RNA · doi:10.1261/rna.2401811 · Cited by 140
Drugs Targeting p53 Mutations with FDA Approval and in Clinical Trials
Nishikawa, S., & Iwakuma, T. (2023) · Cancers · doi:10.3390/cancers15020429 · Cited by 115
Wasserman, M. R., Pulk, A., Zhou, Z., Altman, R. B., Zinder, J. C., Green, K. D., Garneau-Tsodikova, S., Doudna Cate, J. H., & Blanchard, S. C. (2015) · Nature Communications · doi:10.1038/ncomms8896 · Cited by 77
Metadata
- Authors
- Burke, J. F., & Mogg, A. E.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 1985
- Volume
- 13
- Issue
- 17
- Pages
- 6265-6272
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2074477570
- Cited by
- 218
- References
- 0
- FWCI
- 0.73
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Suppression of a nonsense mutation in mammalian cells in vivo by the aminoglycoside anthiotics G–418 and paromomycin. https://app.cochat.ai/papers/10.1093/nar/13.17.6265
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- Burke, J. F., & Mogg, A. E. (1985). Suppression of a nonsense mutation in mammalian cells in vivo by the aminoglycoside anthiotics G–418 and paromomycin. Nucleic Acids Research. https://doi.org/10.1093/nar/13.17.6265
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
