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Cited by 1,791

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Isolation and characterization of rat and human glyceraldehyde-3-phosphate dehydrogenase cDNAs: genomic complexity and molecular evolution of the gene

Open access
Tso, J. Yun, Sun, Xiao-Hong, Kao, Teh-hui, Reece, Kimberly S., Wu, Ray·1985·Nucleic Acids Research
DOI 10.1093/nar/13.7.2485
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Abstract

Full length cDNAs encoding the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) from rat and man have been isolated and sequenced. Many GAPDH gene-related sequences have been found in both genomes based on genomic blot hybridization analysis. Only one functional gene product is known. Results from genomic library screenings suggest that there are 300-400 copies of these sequences in the rat genome and approximately 100 in the human genome. Some of these related sequences have been shown to be processed pseudogenes. We have isolated several rat cDNA clones corresponding to these pseudogenes indicating that some pseudogenes are transcribed. Rat and human cDNAs are 89% homologous in the coding region, and 76% homologous in the first 100 base pairs of the 3'-noncoding region. Comparison of these two cDNA sequences with those of the chicken, Drosophila and yeast genes allows the analysis of the evolution of the GAPDH genes in detail.

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Metadata

Authors
Tso, J. Y., Sun, X.-H., Kao, T.-H., Reece, K. S., & Wu, R.
Venue
Nucleic Acids Research
Publisher
Oxford University Press (OUP)
Published
1985
Volume
13
Issue
7
Pages
2485-2502
ISSN
  • 0305-1048 (ISSN-L)
  • 1362-4962
DOI
10.1093/nar/13.7.2485
OpenAlex
W1997261857
Cited by
1,791
References
2
FWCI
5.25
Type
journal article
Language
en
Open access
bronze

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