Gsh ‐ 1 : A novel murine homeobox gene expressed in the central nervous system

Valerius, M. Todd; Li, Hung; Stock, Jeffrey L.; Weinstein, Michael; Kaur, Satbir; Singh, Gurparkash; Potter, S. Steven

doi:10.1002/aja.1002030306

Cited by 107Developmental Biology and Gene RegulationNeurogenesis and neuroplasticity mechanismsGenomics and Chromatin Dynamics

Gsh ‐ 1 : A novel murine homeobox gene expressed in the central nervous system

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Valerius, M. Todd, Li, Hung, Stock, Jeffrey L., Weinstein, Michael, Kaur, Satbir, Singh, Gurparkash, Potter, S. Steven·1995·Developmental Dynamics

DOI 10.1002/aja.1002030306

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Abstract

We report the characterization of Gsh ‐ 1 , a novel murine homeobox gene. Northern blot analysis revealed a transcript of approximately 2 kb in size present at embryonic days 10.5, 11.5, and 12.5 of development. The cDNA sequence encoded a proline rich motif, a polyalanine tract, and a homeodomain with strong homology to those encoded by the clustered Hox genes. The Gsh ‐ 1 expression pattern was determined for days E8.5 to E13.5 by whole mount and serial section in situ hybridizations. Gsh ‐ 1 transcription was restricted to the central nervous system. Expression is present in the neural tube and hindbrain as two continuous, bilaterally symmetrical stripes within neural epithelial tissue. In the mesencephalon, expression is seen as a band across the most anterior portion. There is also diencephalon expression in the anlagen of the thalamus and the hypothalamus as well as in the optic stalk, optic recess, and the ganglionic eminence. Moreover, through the use of fusion proteins containing the Gsh ‐ 1 homeodomain, we have determined the consensus DNA ninding site of the Gsh ‐ 1 homeoprotein to be GC T / C A / C ATTA G / A . ©1995 Wiley‐Liss, Inc.

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Vertebrate genes closely related to vnd (Nkx2.1 and Nkx2.2), ind (Gsh1 and Gsh2), and msh (Msx1 and Msx3) are expressed in corresponding ventral, intermediate, and dorsal domains during vertebrate neurogenesis.
“Vertebrate genes closely related to vnd (Nkx2.1 and Nkx2.2), ind (Gsh1 and Gsh2), and msh (Msx1 and Msx3) are expressed in corresponding ventral, intermediate, and dorsal domains during vertebrate neurogenesis”
From Dorsoventral patterning in the Drosophila central nervous system: the intermediate neuroblasts defective homeobox gene specifies intermediate column identity (1998) · cites this paper as Valerius et al. 1995
The In Situ Hybridizations section reports Gsh-1 expression in a restricted mid-ventricular region of the developing mouse neural tube, supporting the intermediate-domain portion of the claim. The Gsh-1 Target DNA Binding Sequence section also reports strong Gsh-1/Gsh-2 homeodomain similarity. Our copy does not establish the proposed relationships to ind, vnd, or msh, or the claimed ventral and dorsal expression patterns of the other listed genes; the passages provide no page numbers. (LLM, conf=0.84)
Experimental — accuracy not yet measured
A putative ind ortholog, Gsh1, is expressed in symmetric lateral domains in the mouse neural tube.
“Consistent with this, a putative ind ortholog, Gsh1, is expressed in symmetric lateral domains in the mouse neural tube (Fig. 7; Valerius et al. 1995).”
From Dorsoventral patterning in the Drosophila central nervous system: the intermediate neuroblasts defective homeobox gene specifies intermediate column identity (1998) · cites this paper as Valerius et al. 1995
The In Situ Hybridizations section and Fig. 4 caption report two bilaterally symmetrical stripes of Gsh-1 expression extending along the mouse neural tube; the thoracic section places expression in a restricted mid-ventricular region. The passages do not identify Gsh-1 as a putative ind ortholog, so that part of the claim is not supported by our copy. (LLM, conf=0.86)
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Authors: Valerius, M. T., Li, H., Stock, J. L., Weinstein, M., Kaur, S., Singh, G., & Potter, S. S.
Affiliations: University of Cincinnati (US)
Merck & Co., Inc., Rahway, NJ, USA (United States) (US)
Corresponding author: Potter, S. Steven
ORCID: Valerius, M. Todd
Li, Hung
Potter, S. Steven
Venue: Developmental Dynamics
Publisher: Wiley
Published: 1995-07
Volume: 203
Issue: 3
Pages: 337-351
ISSN: 1058-8388 (ISSN-L)
1097-0177
DOI: 10.1002/aja.1002030306
OpenAlex: W1969803167
Cited by: 107
References: 80
Citations by year: 2026: 2 · 2024: 1 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 3 · 2017: 2 · 2016: 4 · 2015: 2 · 2014: 4 · 2013: 4 · 2012: 2
FWCI: 1.74
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 3505 d)
Locations: Developmental Dynamics (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01hd029599-09)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD29599)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords: homeobox genes, homeodomain, central nervous system development, gene expression patterns, neural tube, hindbrain, midbrain, diencephalon, ganglionic eminence, optic stalk, DNA binding sites, proline-rich motif, polyalanine tract, mouse embryo
MeSH terms: Amino Acid Sequence, Animals, Base Sequence, Brain, DNA-Binding Proteins, Escherichia coli, Genes, Homeobox, Glutathione Transferase, Molecular Sequence Data, Oligonucleotides, Recombinant Fusion Proteins, Blotting, Northern, Polymerase Chain Reaction, In Situ Hybridization, DNA, Complementary, Gene Expression Regulation, Developmental, Mice

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Gsh ‐ 1 : A novel murine homeobox gene expressed in the central nervous system

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