The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Codon usage in yeast: cluster analysis clearly differentiates highly and lowly expressed genes
Open accessAbstract
Codon usage data has been compiled for 110 yeast genes. Cluster analysis on relative synonymous codon usage revealed two distinct groups of genes. One group corresponds to highly expressed genes, and has much more extreme synonymous codon preference. The pattern of codon usage observed is consistent with that expected if a need to match abundant tRNAs, and intermediacy of tRNA-mRNA interaction energies are important selective constraints. Thus codon usage in the highly expressed group shows a higher correlation with tRNA abundance, a greater degree of third base pyrimidine bias, and a lesser tendency to the A+T richness which is characteristic of the yeast genome. The cluster analysis can be used to predict the likely level of gene expression of any gene, and identifies the pattern of codon usage likely to yield optimal gene expression in yeast.
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Citations
Cites
Codon specificity of starvation induced misreading
Johnston, T. C., Borgia, P. T., & Parker, J. (1984) · Molecular and General Genetics MGG · doi:10.1007/bf00341447 · Cited by 47
Cited by
Sharp, P. M., & Li, W.-H. (1987) · Nucleic Acids Research · doi:10.1093/nar/15.3.1281 · Cited by 3,992
Self-citationUnderstanding the contribution of synonymous mutations to human disease
Sauna, Z. E., & Kimchi-Sarfaty, C. (2011) · Nature Reviews Genetics · doi:10.1038/nrg3051 · Cited by 1,022
Sharp, P. M., Cowe, E., Higgins, D. G., Shields, D. C., Wolfe, K. H., & Wright, F. (1988) · Nucleic Acids Research · doi:10.1093/nar/16.17.8207 · Cited by 594
Self-citationSequence and structural features associated with translational initiator regions in yeast—A review
Mark Cigan, A., & Donahue, T. F. (1987) · Gene · doi:10.1016/0378-1119(87)90261-7 · Cited by 359
A critical analysis of codon optimization in human therapeutics
Mauro, V. P., & Chappell, S. A. (2014) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2014.09.003 · Cited by 343
Metadata
- Authors
- Sharp, P. M., Tuohy, T. M. F., & Mosurski, K. R.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 1986
- Volume
- 14
- Issue
- 13
- Pages
- 5125-5143
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2051043527
- Cited by
- 1,200
- References
- 1
- FWCI
- 14.09
- Type
- journal article
- Language
- en
- Open access
- green
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- Sharp, P. M., Tuohy, T. M. F., & Mosurski, K. R. (1986). Codon usage in yeast: cluster analysis clearly differentiates highly and lowly expressed genes. Nucleic Acids Research. https://doi.org/10.1093/nar/14.13.5125
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