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Sigma factors from E. coli, B. subtilis, phage SP01, and phage T4 are homologous proteins
Open accessAbstract
We show, using dot matrix comparisons and statistical analysis of sequence alignments, that seven sequenced sigma factors, E. coli sigma-70 and sigma-32, B. subtilis sigma-43 and sigma-29, phage SP01 gene products 28 and 34, and phage T4 gene product 55, comprise a homologous family of proteins. Sigma-70, sigma-32, and sigma-43 each have two copies of a sequence similar to the helix-turn-helix DNA binding motif seen in CRP, and lambda repressor and cro proteins. B. subtilis sigma-29, SP01 gp28, and SP01 gp34 have at least one copy similar to this sequence. We propose that a second sequence, conserved in all seven proteins is the core RNA polymerase binding site. A third region, present only in sigma-70 and sigma-43, may also be involved in interaction with core. Available mutational evidence supports our model for sigma factor structure.
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Cited by
Profile analysis: detection of distantly related proteins.
Gribskov, M., McLachlan, A. D., & Eisenberg, D. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.13.4355 · Cited by 1,325
Self-citationHallböök, F., Ibáñez, C. F., & Persson, H. (1991) · Neuron · doi:10.1016/0896-6273(91)90180-8 · Cited by 834
Nollet, F., Kools, P., & van Roy, F. (2000) · Journal of Molecular Biology · doi:10.1006/jmbi.2000.3777 · Cited by 698
Laporte, J., Hu, L. J., Kretz, C., Mandel, J.-L., Kioschis, P., Coy, J. F., Klauck, S. M., Poustka, A., & Dahl, N. (1996) · Nature Genetics · doi:10.1038/ng0696-175 · Cited by 639
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Nakane, M., Schmidt, H. H. H. W., Pollock, J. S., Förstermann, U., & Murad, F. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)81210-q · Cited by 546
Metadata
- Authors
- Gribskov, M., & Burgess, R. R.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 1986
- Volume
- 14
- Issue
- 16
- Pages
- 6745-6763
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2110510425
- Cited by
- 445
- References
- 0
- FWCI
- 18.87
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Gribskov, M., & Burgess, R. R. (1986). Sigma factors from E. coli, B. subtilis, phage SP01, and phage T4 are homologous proteins. Nucleic Acids Research. https://doi.org/10.1093/nar/14.16.6745
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