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Cloning of cDNA for human T-cell replacing factor (interieukin-5) and comparison with the murine homologue
Open accessAbstract
We have cloned cDNA for T-cell replacing factor (interleukin-5), which replaces T-cell helper function for normal B cells which secrete immunoglobulin, from human T cell leukemia line, ATL-2, using mouse interleukin-5 cDNA as probe. Total nucleotide sequence of the cDNA (816 base pairs) was determined and compared with that of mouse interleukin-5 cDNA. The cloned cDNA encoded the interleukin-5 precursor of 134 amino acids containing an N-terminal signal sequence. Although the human interleukin-5 precursor is one amino acid longer than the murine homologue, the sizes of the mature proteins appear similar. The nucleotide and amino acid sequence homologies of the coding regions of human and murine interleukin-5 are 77% and 70%, respectively. Human interleukin-5 synthesized by the direction of the cloned cDNA induced immunoglobulin synthesis in human B cells stimulated by Staphylococcus aureus mitogen.
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Citations
Cited by
Clutterbuck, E., Hirst, E., & Sanderson, C. (1989) · Blood · doi:10.1182/blood.v73.6.1504.1504 · Cited by 687
Molecular Regulation of B Lymphocyte Response
Kishimoto, T., & Hirano, T. (1988) · Annual Review of Immunology · doi:10.1146/annurev.iy.06.040188.002413 · Cited by 567
Low nucleotide diversity in man.
Li, W. H., & Sadler, L. A. (1991) · Genetics · doi:10.1093/genetics/129.2.513 · Cited by 501
Yamaguchi, Y., Suda, T., Ohta, S., Tominaga, K., Miura, Y., & Kasahara, T. (1991) · Blood · doi:10.1182/blood.v78.10.2542.2542 · Cited by 308
Regulation of IgA synthesis and immune response by T cells and interleukins
McGhee, J. R., Mestecky, J., Elson, C. O., & Kiyono, H. (1989) · Journal of Clinical Immunology · doi:10.1007/bf00916814 · Cited by 276
Metadata
- Authors
- Azuma, C., Tanabe, T., Konishi, M., Kinashi, T., Noma, T., Matsuda, F., Yaoita, Y., Takatsu, K., Hammarström, L., Edvard Smith, C. I., Severinson, E., & Honjo, T.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 1986
- Volume
- 14
- Issue
- 22
- Pages
- 9149-9158
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2114194173
- Cited by
- 205
- References
- 0
- FWCI
- 10.02
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Cloning of cDNA for human T-cell replacing factor (interieukin-5) and comparison with the murine homologue. https://app.cochat.ai/papers/10.1093/nar/14.22.9149
- The paper
- Azuma, C., Tanabe, T., Konishi, M., Kinashi, T., Noma, T., Matsuda, F., Yaoita, Y., Takatsu, K., Hammarström, L., Edvard Smith, C. I., Severinson, E., & Honjo, T. (1986). Cloning of cDNA for human T-cell replacing factor (interieukin-5) and comparison with the murine homologue. Nucleic Acids Research. https://doi.org/10.1093/nar/14.22.9149
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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