The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Analysis of the survival of mature human eosinophils: interleukin-5 prevents apoptosis in mature human eosinophils
Open accessAbstract
We and other groups have previously shown that interleukin-5 (IL-5) maintained the viability of mature eosinophils in an in vitro liquid culture system. Mature eosinophils did not proliferate but their survival was maintained in the presence of IL-5. Using this culture system, we investigated the mechanism of IL-5-mediated survival. In the absence of human IL-5 (hIL-5) mature eosinophils succumbed after 4 days, while in the presence of hIL-5 they survived up to 10 days. When DNA extracts of cultured eosinophils were analyzed on an agar gel electrophoresis, marked DNA fragmentation was observed in the absence of hIL-5, while no significant DNA fragmentation was observed in the culture with hIL-5 for 48 hours. The DNA fragmentation appeared as early as 6 to 12 hours after hIL-5 deprivation. Concomitantly, IL-5 stimulated total RNA and protein synthesis, but did not induce DNA synthesis in mature eosinophils. Because cycloheximide or actinomycin D impeded the protection of apoptosis by hIL-5, some new RNA and protein synthesis appeared to be required in this phenomena. These findings indicate that IL-5 maintains survival of mature eosinophils with induction of new RNA and protein synthesis, thus leading to the inhibition of apoptosis.
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Cites
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Cited by
Oldhoff, J. M., Darsow, U., Werfel, T., Katzer, K., Wulf, A., Laifaoui, J., Hijnen, D. J., Plötz, S., Knol, E. F., Kapp, A., et al. (2005) · Allergy · doi:10.1111/j.1398-9995.2005.00791.x · Cited by 339
A role for eosinophils in airway remodelling in asthma
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Metadata
- Authors
- Yamaguchi, Y., Suda, T., Ohta, S., Tominaga, K., Miura, Y., & Kasahara, T.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 1991-11-15
- Volume
- 78
- Issue
- 10
- Pages
- 2542-2547
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2414964888
- Cited by
- 308
- References
- 20
- FWCI
- 6.32
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Analysis of the survival of mature human eosinophils: interleukin-5 prevents apoptosis in mature human eosinophils. https://app.cochat.ai/papers/10.1182/blood.v78.10.2542.2542
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- Yamaguchi, Y., Suda, T., Ohta, S., Tominaga, K., Miura, Y., & Kasahara, T. (1991). Analysis of the survival of mature human eosinophils: interleukin-5 prevents apoptosis in mature human eosinophils. Blood. https://doi.org/10.1182/blood.v78.10.2542.2542
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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