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Evidence for a locus activation region: the formation of developmentally stable hypersensitive sites in globin-expressing hybrids
Open accessAbstract
We have analyzed the chromatin structure of the human beta-globin locus in somatic cell hybrids resulting from the fusion of human non-erythroid cells and mouse erythroleukemia (MEL) cells. In these hybrids, the human adult beta-globin gene, but neither the embryonic nor fetal globin genes, is activated transcriptionally. In addition, the DNase I-resistant beta-like globin locus characteristic of the parental non-erythroid human cells (1,2) is reorganized over an approximately 80 kb region, including the formation of the developmentally stable hypersensitive sites 50 kb 5' and 20 kg 3' of the activated adult beta-globin gene (2,3). These results are consistent with the hypothesis that events occurring at the 5' and/or 3' developmentally stable hypersensitive sites are important, if not necessary, for the activation of the beta-globin locus.
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Cites
Human myeloid leukemia cell lines: a review
Koeffler, H., & Golde, D. (1980) · Blood · doi:10.1182/blood.v56.3.344.344 · Cited by 349
Cited by
Moi, P., Chan, K., Asunis, I., Cao, A., & Kan, Y. W. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.21.9926 · Cited by 1,607
Chung, J. H., Whiteley, M., & Felsenfeld, G. (1993) · Cell · doi:10.1016/0092-8674(93)80052-g · Cited by 854
Nrf2 is essential for protection against acute pulmonary injury in mice
Chan, K., & Kan, Y. W. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.22.12731 · Cited by 574
May, C., Rivella, S., Callegari, J., Heller, G., Gaensler, K. M. L., Luzzatto, L., & Sadelain, M. (2000) · Nature · doi:10.1038/35017565 · Cited by 567
Li, Q., Peterson, K. R., Fang, X., & Stamatoyannopoulos, G. (2002) · Blood · doi:10.1182/blood-2002-04-1104 · Cited by 456
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Metadata
- Authors
- Forrester, W. C., Takegawa, S., Papayannopoulou, T., Stamatoyannopoulos, G., & Groudine, M.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 1987
- Volume
- 15
- Issue
- 24
- Pages
- 10159-10177
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2006918190
- Cited by
- 418
- References
- 1
- FWCI
- 10.30
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Forrester, W. C., Takegawa, S., Papayannopoulou, T., Stamatoyannopoulos, G., & Groudine, M. (1987). Evidence for a locus activation region: the formation of developmentally stable hypersensitive sites in globin-expressing hybrids. Nucleic Acids Research. https://doi.org/10.1093/nar/15.24.10159
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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