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Two related superfamilies of putative helicases involved in replication, recombination, repair and expression of DNA and RNA genomes
Open accessAbstract
In the course of systematic analysis of protein sequences containing the purine NTP-binding motif, a new superfamily was delineated which included 25 established or putative helicases of Escherichia coli, yeast, insects, mammals, pox- and herpesviruses, a yeast mitochondrial plasmid and three groups of positive strand RNA viruses. These proteins contained 7 distinct highly conserved segments two of which corresponded to the "A" and "B" sites of the NTP-binding motif. Typical of the new superfamily was an abridged consensus for the "A" site, GxGKS/T, instead of the classical G/AxxxxGKS/T. Secondary structure predictions indicated that each of the conserved segments might constitute a separate structural unit centering at a beta-turn. All previously characterized mutations impairing the function of the yeast helicase RAD3 in DNA repair mapped to one of the conserved segments. A degree of similarity was revealed between the consensus pattern of conserved amino acid residues derived for the new superfamily and that of another recently described protein superfamily including a different set of prokaryotic, eukaryotic and viral (putative) helicases.
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Cited by
The alphaviruses: gene expression, replication, and evolution.
Strauss, J. H., & Strauss, E. G. (1994) · Microbiological Reviews · doi:10.1128/mmbr.58.3.491-562.1994 · Cited by 2,221
Molecular biology of flaviviruses
Lindenbach, B. D., & Rice, C. M. (2003) · Advances in Virus Research · doi:10.1016/s0065-3527(03)59002-9 · Cited by 853
Troelstra, C., van Gool, A., de Wit, J., Vermeulen, W., Bootsma, D., & Hoeijmakers, J. H. J. (1992) · Cell · doi:10.1016/0092-8674(92)90390-x · Cited by 729
Reardon, J. T., & Sancar, A. (2005) · Progress in Nucleic Acid Research and Molecular Biology · doi:10.1016/s0079-6603(04)79004-2 · Cited by 350
Mutant chromatin remodeling protein SMARCAL1 causes Schimke immuno-osseous dysplasia
Boerkoel, C. F., Takashima, H., John, J., Yan, J., Stankiewicz, P., Rosenbarker, L., André, J.-L., Bogdanovic, R., Burguet, A., Cockfield, S., et al. (2002) · Nature Genetics · doi:10.1038/ng821 · Cited by 329
Metadata
- Authors
- Gorbalenya, A. E., Koonin, E. V., Donchenko, A. P., & Blinov, V. M.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 1989
- Volume
- 17
- Issue
- 12
- Pages
- 4713-4730
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2086826197
- Cited by
- 996
- References
- 0
- FWCI
- 14.38
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Gorbalenya, A. E., Koonin, E. V., Donchenko, A. P., & Blinov, V. M. (1989). Two related superfamilies of putative helicases involved in replication, recombination, repair and expression of DNA and RNA genomes. Nucleic Acids Research. https://doi.org/10.1093/nar/17.12.4713
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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