The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Identification of two transactlvation domains in the mouse oestrogen receptor
Open accessAbstract
We have identified two discrete transactivation domains within the mouse oestrogen receptor whose relative activities vary according to the target promoter. One domain lies within the N-terminal region and is active in the absence of oestradiol. The second domain is contained within the C-terminal portion of the protein and depends upon oestrogen binding for its activity. The location and oestrogen dependence of this domain has been confirmed using chimaeric receptors containing the Lex A DNA binding domain. Although transactivation by the C-terminal domain is dependent upon ligand binding the analysis of receptor deletion mutants has demonstrated that these two functions are not entirely coincident.
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Citations
Cites
Gene regulation by steroid hormones
Beato, M. (1989) · Cell · doi:10.1016/0092-8674(89)90237-7 · Cited by 3,383
Cited by
Cloning of a novel receptor expressed in rat prostate and ovary.
Kuiper, G. G., Enmark, E., Pelto-Huikko, M., Nilsson, S., & Gustafsson, J. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.12.5925 · Cited by 4,788
Estrogen Receptor Null Mice: What Have We Learned and Where Will They Lead Us?
Couse, J. F., & Korach, K. S. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.3.0370 · Cited by 2,045
Environmentally persistent alkylphenolic compounds are estrogenic
White, R., Jobling, S., Hoare, S., Sumpter, J. P., & Parker, M. G. (1994) · Endocrinology · doi:10.1210/en.135.1.175 · Cited by 1,451
Self-citationSchoonjans, K., Staels, B., & Auwerx, J. (1996) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)42003-6 · Cited by 1,216
Danielian, P. S., White, R., Lees, J. A., & Parker, M. G. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05141.x · Cited by 803
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Metadata
- Authors
- Lees, J. A., Fawell, S. E., & Parker, M. G.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 1989
- Volume
- 17
- Issue
- 14
- Pages
- 5477-5488
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W1964520022
- Cited by
- 295
- References
- 1
- FWCI
- 12.36
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Lees, J. A., Fawell, S. E., & Parker, M. G. (1989). Identification of two transactlvation domains in the mouse oestrogen receptor. Nucleic Acids Research. https://doi.org/10.1093/nar/17.14.5477
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
