Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression

Schoonjans, K; Staels, B; Auwerx, J

doi:10.1016/s0022-2275(20)42003-6

Cited by 1,216Peroxisome Proliferator-Activated ReceptorsCholesterol and Lipid MetabolismLipid metabolism and disorders

Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression

Open access

Schoonjans, K, Staels, B, Auwerx, J·1996·Journal of Lipid Research

DOI 10.1016/s0022-2275(20)42003-6

Open this paper in CoChat — free account

Abstract

The three types of peroxisome proliferator-activated receptors (PPAR), termed alpha, delta (or beta), and gamma, belong to the nuclear receptor superfamily. Although peroxisome proliferators, including fibrates and fatty acids, activate the transcriptional activity of these receptors, only prostaglandin J2 derivatives have been identified as natural ligands of the PPAR gamma subtype that also binds thiazolidinedione antidiabetic agents with high affinity. PPARs heterodimerize with retinoic X receptor (RXR) and alter the transcription of target genes after binding to response elements or PPREs, consisting of a direct repeat of the nuclear receptor hexameric DNA recognition motif (PuGGTCA) spaced by 1 nucleotide (DR-1). Upon activation by fatty acids (FAs) and drugs that affect lipid metabolism, PPARs control the expression of genes implicated in intra- and extracellular lipid metabolism, most notably those involved in peroxisomal beta-oxidation. PPARs partially mediate the inductive effects of fibrates and fatty acids on high density lipoprotein (HDL) cholesterol levels by regulating the transcription of the major HDL apolipoproteins, apoA-I and apoA-II. The hypotriglyceridemic action of fibrates and certain fatty acids also involves PPAR and is constituted of: 1) increased hydrolysis of plasma triglycerides due to induction of LPL and reduction of apoC-III expression; 2) stimulation of cellular fatty acid uptake and conversion to acyl-CoA derivatives due to increased expression of genes for fatty acid transport protein and acyl-CoA synthetase; 3) increased peroxisomal and mitochondrial beta-oxidation; and 4) decreased synthesis of fatty acids and triglycerides and decreased production of very low density lipoprotein (VLDL). Hence, both enhanced catabolism of triglyceride-rich particles and reduced secretion of VLDL particles contribute to the hypolipidemic effect of fibrates and fatty acids. Finally, PPARs appear to be involved in differentiation processes because activation of PPAR gamma 2 triggers adipocyte differentiation and stimulates expression of several genes critical to adipogenesis. It is suggested that PPARs are key messengers responsible for the translation of nutritional and pharmacological stimuli into changes in gene expression and differentiation pathways.

Integrity signals

Registry

Crossref · 10.1016/s0022-2275(20)42003-6

Cites

198 of 198 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Even in patients with homozygous familial hypercholesterolemia for whom other drug therapies show no effect, lomitapide decreases the LDL-C level by approximately 50%.
“Even in patients with homozygous FH (HoHF) for whom other drug therapies show no effect, lomitapide decreases the LDL-C level by approximately 50%.”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [684]
Four weeks after starting a low-fat diet and lomitapide in patients with homozygous familial hypercholesterolemia, LDL-C decreased by 50.9% and apo-B by 55.6%, with an average pretreatment LDL-C level of 615 mg/dL.
“Four weeks following commencement of a low-fat diet and administration of lomitapide in patients with hoFH, the blood LDL-C level and apo-B level decreased by 50.9% and 55.6%, respectively (average pretreatment LDL-C level: 615 mg/dL)684).”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [684]

The Steroid and Thyroid Hormone Receptor Superfamily
Evans, R. M. (1988) · Science · doi:10.1126/science.3283939 · Cited by 7,442 · see citing works
The nuclear receptor superfamily: the second decade
Mangelsdorf, D. J., Thummel, C., Beato, M., Herrlich, P., Schütz, G., Umesono, K., Blumberg, B., Kastner, P., Mark, M., Chambon, P., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90199-x · Cited by 6,964 · see citing works
An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)
Lehmann, J. M., Moore, L. B., Smith-Oliver, T. A., Wilkison, W. O., Willson, T. M., & Kliewer, S. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.22.12953 · Cited by 3,626 · see citing works
Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor
Tontonoz, P., Hu, E., & Spiegelman, B. M. (1994) · Cell · doi:10.1016/0092-8674(94)90006-x · Cited by 3,533 · see citing works
Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
Issemann, I., & Green, S. (1990) · Nature · doi:10.1038/347645a0 · Cited by 3,519 · see citing works
The RXR heterodimers and orphan receptors
Mangelsdorf, D. J., & Evans, R. M. (1995) · Cell · doi:10.1016/0092-8674(95)90200-7 · Cited by 3,133 · see citing works
MOLECULAR MECHANISMS OF ACTION OF STEROID/THYROID RECEPTOR SUPERFAMILY MEMBERS
Tsai, M., & O’Malley, B. W. (1994) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.63.070194.002315 · Cited by 2,887 · see citing works
15-Deoxy-Δ12,14-Prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ
FORMAN, B. M., Tontonoz, P., Chen, J., Brun, R. P., Spiegelman, B. M., & Evans, R. M. (1995) · Cell · doi:10.1016/0092-8674(95)90193-0 · Cited by 2,858 · see citing works
Sequence and Characterization of a Coactivator for the Steroid Hormone Receptor Superfamily
Oñate, S., Tsai, S., Tsai, M.-J., & O'Malley, B. (1995) · Science · doi:10.1126/science.270.5240.1354 · Cited by 2,507 · see citing works
Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat
Braissant, O., Foufelle, F., Scotto, C., Dauça, M., & Wahli, W. (1996) · Endocrinology · doi:10.1210/endo.137.1.8536636 · Cited by 2,217 · see citing works
mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer.Preprint
Tontonoz, P., Hu, E., Graves, R. A., Budavari, A. I., & Spiegelman, B. M. (1994) · Genes & Development · doi:10.1101/gad.8.10.1224 · Cited by 2,182 · see citing works
Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor
Hörlein, A., Näär, A. M., Heinzel, T., Torchia, J., Gloss, B. R., Kurokawa, R., Ryan, A. K., Kamei, Y., Söderström, M., Glass, C. K., et al. (1995) · Nature · doi:10.1038/377397a0 · Cited by 2,035 · see citing works
A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation
Kliewer, S. A., Lenhard, J. M., Willson, T. M., Patel, I., Morris, D. C., & Lehmann, J. M. (1995) · Cell · doi:10.1016/0092-8674(95)90194-9 · Cited by 2,028 · see citing works
A transcriptional co-repressor that interacts with nuclear hormone receptors
Chen, J. D., & Evans, R. M. (1995) · Nature · doi:10.1038/377454a0 · Cited by 1,794 · see citing works
Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors
Kliewer, S. A., Umesono, K., Noonan, D. J., Heyman, R. A., & Evans, R. M. (1992) · Nature · doi:10.1038/358771a0 · Cited by 1,741 · see citing works
Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors
Umesono, K., Murakami, K. K., Thompson, C. C., & Evans, R. M. (1991) · Cell · doi:10.1016/0092-8674(91)90020-y · Cited by 1,688 · see citing works
Targeted Disruption of the α Isoform of the Peroxisome Proliferator-Activated Receptor Gene in Mice Results in Abolishment of the Pleiotropic Effects of Peroxisome Proliferators
Lee, S. S. T., Pineau, T., Drago, J., Lee, E. J., Owens, J. W., Kroetz, D. L., Fernández‐Salguero, P. M., Westphal, H., & Gonzalez, F. J. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.6.3012 · Cited by 1,655 · see citing works
Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA
Luisi, B. F., Xu, W. X., Otwinowski, Z., Freedman, L. P., Yamamoto, K. R., & Sigler, P. B. (1991) · Nature · doi:10.1038/352497a0 · Cited by 1,503 · see citing works
Molecular physiology of reverse cholesterol transport.
Fielding, C. J., & Fielding, P. E. (1995) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39898-9 · Cited by 1,448 · see citing works
Differential expression and activation of a family of murine peroxisome proliferator-activated receptors.
Kliewer, S. A., FORMAN, B. M., Blumberg, B., Ong, E. S., Borgmeyer, U., Mangelsdorf, D. J., Umesono, K., & Evans, R. M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.15.7355 · Cited by 1,400 · see citing works
Control of the peroxisomal β-oxidation pathway by a novel family of nuclear hormone receptors
Dreyer, C., Krey, G. D., Keller, H., Givel, F., Helftenbein, G., & Wahli, W. (1992) · Cell · doi:10.1016/0092-8674(92)90031-7 · Cited by 1,373 · see citing works
Transcription Factor Interactions: Selectors of Positive or Negative Regulation from a Single DNA Element
Diamond, M. I., Miner, J. N., Yoshinaga, S. K., & Yamamoto, K. R. (1990) · Science · doi:10.1126/science.2119054 · Cited by 1,274 · see citing works
PPARalpha and PPARgamma activators direct a distinct tissue‐specific transcriptional response via a PPRE in the lipoprotein lipase gene.
Schoonjans, K., Peinado‐Onsurbe, J., Lefebvre, A. M., Heyman, R. A., Briggs, M., Deeb, S., Staels, B., & Auwerx, J. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00918.x · Cited by 1,173 · see citing works
Self-citation
LXR, a nuclear receptor that defines a distinct retinoid response pathway.Preprint
Willy, P. J., Umesono, K., Ong, E. S., Evans, R. M., Heyman, R. A., & Mangelsdorf, D. J. (1995) · Genes & Development · doi:10.1101/gad.9.9.1033 · Cited by 1,124 · see citing works
The human estrogen receptor has two independent nonacidic transcriptional activation functions
Tora, L., White, J. H., Brou, C., Tasset, D., Webster, N. J. G., Scheer, E., & Chambon, P. (1989) · Cell · doi:10.1016/0092-8674(89)90031-7 · Cited by 1,049 · see citing works
Nuclear receptors enhance our understanding of transcription regulation
Green, S., & Chambon, P. (1988) · Trends in Genetics · doi:10.1016/0168-9525(88)90108-4 · Cited by 1,042 · see citing works
Inhibition of early atherogenesis in transgenic mice by human apolipoprotein AI
Rubin, E. M., Krauss, R. M., Spangler, E. A., Verstuyft, J. G., & Clift, S. (1991) · Nature · doi:10.1038/353265a0 · Cited by 985 · see citing works
Fatty acids and retinoids control lipid metabolism through activation of peroxisome proliferator-activated receptor-retinoid X receptor heterodimers.
Keller, H., Dreyer, C., Medin, J. A., Mahfoudi, A., Ozato, K., & Wahli, W. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.6.2160 · Cited by 948 · see citing works
The mouse peroxisome proliferator activated receptor recognizes a response element in the 5′ flanking sequence of the rat acyl CoA oxidase gene
Tugwood, J. D., Issemann, I., Anderson, R. G., Bundell, K. R., McPheat, W. L., & Green, S. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05072.x · Cited by 895 · see citing works
Carcinogenesis by Hepatic Peroxisome Proliferators: Evaluation of the Risk of Hypolipidemic Drugs and Industrial Plasticizers to Humans
Reddy, J. K., Lalvvai, N. D., & Farber, E. (1983) · Critical Reviews in Toxicology · doi:10.3109/10408448309029317 · Cited by 879 · see citing works
Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein
Schaffer, J. E., & Lodish, H. F. (1994) · Cell · doi:10.1016/0092-8674(94)90252-6 · Cited by 868 · see citing works
Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor.
Göttlicher, M., Widmark, E., Li, Q., & Gustafsson, J.-Α. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.10.4653 · Cited by 857 · see citing works
Multiplicity generates diversity in the retinoic acid signalling pathways
Leid, M., Kastner, P., & Chambon, P. (1992) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(92)90014-z · Cited by 821 · see citing works
The crystal structure of the estrogen receptor DNA-binding domain bound to DNA: how receptors discriminate between their response elements
Schwabe, J. W. R., Chapman, L., Finch, J. T., & Rhodes, D. (1993) · Cell · doi:10.1016/0092-8674(93)90390-c · Cited by 750 · see citing works
Differential Activation of Peroxisome Proliferator-activated Receptors by Eicosanoids
Yu, K., Bayona, W., Kallen, C. B., Harding, H. P., Ravera, C., McMahon, G., Brown, M. A., & Lazar, M. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.41.23975 · Cited by 709 · see citing works
Structural organization of mouse peroxisome proliferator-activated receptor gamma (mPPAR gamma) gene: alternative promoter use and different splicing yield two mPPAR gamma isoforms.
Zhu, Y., Qi, C., Korenberg, J. R., Chen, X. N., Noya, D., Rao, M. S. R., & Reddy, J. K. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.17.7921 · Cited by 653 · see citing works
Estrogen Receptor-Associated Proteins: Possible Mediators of Hormone-Induced Transcription
Halachmi, S., Marden, E., Martin, G., MacKay, H., Abbondanza, C., & Brown, M. A. (1994) · Science · doi:10.1126/science.8197458 · Cited by 637 · see citing works
Unique response pathways are established by allosteric interactions among nuclear hormone receptors
FORMAN, B. M., Umesono, K., Chen, J., & Evans, R. M. (1995) · Cell · doi:10.1016/0092-8674(95)90075-6 · Cited by 625 · see citing works
The orientation and spacing of core DNA-binding motifs dictate selective transcriptional responses to three nuclear receptors
Näär, A. M., Boutin, J. A., Lipkin, S. M., Yu, V. C. K., Holloway, J. M., Glass, C. K., & Rosenfeld, M. G. (1991) · Cell · doi:10.1016/0092-8674(91)90021-p · Cited by 568 · see citing works
Dopaminergic and Ligand-Independent Activation of Steroid Hormone Receptors
Power, R. F., Mani, S. K., Codina, J., Conneely, O. M., & O’Malley, B. W. (1991) · Science · doi:10.1126/science.1749936 · Cited by 563 · see citing works
The peroxisome proliferator-activated receptor regulates mitochondrial fatty acid oxidative enzyme gene expression.
Gulick, T., Cresci, S., Caira, T., Moore, D. D., & Kelly, D. P. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.23.11012 · Cited by 560 · see citing works
Differentiation-induced gene expression in 3T3-L1 preadipocytes: CCAAT/enhancer binding protein interacts with and activates the promoters of two adipocyte-specific genes.Preprint
Christy, R. J., Yang, V. W., Ntambi, J. M., Geiman, D. E., Landschulz, W. H., Friedman, A. D., Nakabeppu, Y., Kelly, T. J., & Lane, M. D. (1989) · Genes & Development · doi:10.1101/gad.3.9.1323 · Cited by 559 · see citing works
PPARγ2 Regulates Adipose Expression of the Phosphoenolpyruvate Carboxykinase Gene
Tontonoz, P., Hu, E., Devine, J. H., BEALE, E. G., & Spiegelman, B. M. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.1.351 · Cited by 559 · see citing works
Identification of the DNA Binding Site for NGFI-B by Genetic Selection in Yeast
Wilson, T. E., Fahrner, T. J., Johnston, M., & Milbrandt, J. (1991) · Science · doi:10.1126/science.1925541 · Cited by 557 · see citing works
A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1.Preprint
Perlmann, T., & Jansson, L. E. (1995) · Genes & Development · doi:10.1101/gad.9.7.769 · Cited by 548 · see citing works
Hypertriglyceridemia as a Result of Human apo CII Gene Expression in Transgenic Mice
Ito, Y., Azrolan, N., O'Connell, A., Walsh, A., & Breslow, J. L. (1990) · Science · doi:10.1126/science.2167514 · Cited by 539 · see citing works
Conditional ectopic expression of C/EBP beta in NIH-3T3 cells induces PPAR gamma and stimulates adipogenesis.Preprint
Wu, Z., Xie, Y., Bucher, N. L. R., & Farmer, S. R. (1995) · Genes & Development · doi:10.1101/gad.9.19.2350 · Cited by 534 · see citing works
cDNA cloning, chromosomal mapping, and functional characterization of the human peroxisome proliferator activated receptor
Sher, T., Yi, H. F., McBride, O. W., & Gonzalez, F. J. (1993) · Biochemistry · doi:10.1021/bi00072a015 · Cited by 519 · see citing works
Isoform-specific amino-terminal domains dictate DNA-binding properties of ROR alpha, a novel family of orphan hormone nuclear receptors.Preprint
Giguère, V., Tini, M., Flock, G. B., Ong, E. S., Evans, R. M., & Otulakowski, G. (1994) · Genes & Development · doi:10.1101/gad.8.5.538 · Cited by 488 · see citing works
Identification of a new member of the steroid hormone receptor superfamily that is activated by a peroxisome proliferator and fatty acids
Schmidt, A., Endo, N., Rutledge, S. J., Vogel, R., SHINAR, D. M., & Rodan, G. A. (1992) · Molecular Endocrinology · doi:10.1210/mend.6.10.1333051 · Cited by 476 · see citing works
Stimulation of estrogen receptor-mediated transcription and alteration in the phosphorylation state of the rat uterine estrogen receptor by estrogen, cyclic adenosine monophosphate, and insulin-like growth factor-I
Aronica, S. M., & Katzenellenbogen, B. S. (1993) · Molecular Endocrinology · doi:10.1210/mend.7.6.7689695 · Cited by 455 · see citing works
Ectopic expression of the CCAAT/enhancer-binding protein alpha promotes the adipogenic program in a variety of mouse fibroblastic cells.Preprint
Freytag, S. O., Paielli, D. L., & Gilbert, J. D. (1994) · Genes & Development · doi:10.1101/gad.8.14.1654 · Cited by 450 · see citing works
Mechanism of hypertriglyceridemia in human apolipoprotein (apo) CIII transgenic mice. Diminished very low density lipoprotein fractional catabolic rate associated with increased apo CIII and reduced apo E on the particles.
Aalto‐Setälä, K., Fisher, E. A. A., Chen, X., Chajek‐Shaul, T., Hayek, T., Zechner, R., Walsh, A., Ramakrishnan, R., Ginsberg, H. N., & Breslow, J. L. (1992) · Journal of Clinical Investigation · doi:10.1172/jci116066 · Cited by 450 · see citing works
Hormone-mediated repression: a negative glucocorticoid response element from the bovine prolactin gene.Preprint
Sakai, D. D., Helms, S. R., Carlstedt‐Duke, J., Gustafsson, J.-Α., ROTTMAN, F. M., & Yamamoto, K. R. (1988) · Genes & Development · doi:10.1101/gad.2.9.1144 · Cited by 448 · see citing works
Opposing effects of apolipoproteins E and C on lipoprotein binding to low density lipoprotein receptor-related protein.
Kowal, R. C., Herz, J., Weisgraber, K. H., Mahley, R. W., Brown, M. S., & Goldstein, J. L. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)87014-4 · Cited by 445 · see citing works
Regulation of retinoid signalling by receptor polarity and allosteric control of ligand binding
Kurokawa, R., DiRenzo, J., Boehm, M., Sugarman, J., Gloss, B., Rosenfeld, M. G., Heyman, R. A., & Glass, C. K. (1994) · Nature · doi:10.1038/371528a0 · Cited by 429 · see citing works
Interaction of thyroid-hormone receptor with a conserved transcriptional mediator
Lee, J. W., Ryan, F., Swaffield, J. C., Johnston, S. A., & Moore, D. D. (1995) · Nature · doi:10.1038/374091a0 · Cited by 425 · see citing works
Apolipoprotein B metabolism in subjects with deficiency of apolipoproteins CIII and AI: evidence that apolipoprotein CIII inhibits catabolism of triglyceride-rich lipoproteins by lipoprotein lipase in vivo
Ginsberg, H. N., Le, N. A., Goldberg, I. J., Gibson, J. C., Rubinstein, A., Wang-Iverson, P., Norum, R., & Brown, W. V. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112713 · Cited by 424 · see citing works
Biochemical Mechanisms Of Induction Of Hepatic Peroxisome Proliferation
Lock, E. A., Mitchell, A. M., & Elcombe, C. R. (1989) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.29.040189.001045 · Cited by 424 · see citing works
Modulation of lipoprotein lipase activity by apolipoproteins. Effect of apolipoprotein C-III.
Wang, C. S., McConathy, W. J., Kloer, H. U., & Alaupovic, P. (1985) · Journal of Clinical Investigation · doi:10.1172/jci111711 · Cited by 414 · see citing works
Fibrates downregulate apolipoprotein C-III expression independent of induction of peroxisomal acyl coenzyme A oxidase. A potential mechanism for the hypolipidemic action of fibrates.
Staels, B., Vu-Dac, N., Kosykh, V. A., Saladin, R., Fruchart, J. C., Dallongeville, J., & Auwerx, J. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117717 · Cited by 410 · see citing works
Self-citation
Human TAFII30 is present in a distinct TFIID complex and is required for transcriptional activation by the estrogen receptor
Jacq, X., Brou, C., Lutz, Y., Davidson, I., Chambon, P., & Tora, L. (1994) · Cell · doi:10.1016/0092-8674(94)90404-9 · Cited by 401 · see citing works
Isolation of the human peroxisome proliferator activated receptor gamma cDNA: expression in hematopoietic cells and chromosomal mapping.
Greene, M. E., Blumberg, B., McBride, O. W., Yi, H., Kronquist, K. E., Kwan, K. W., Hsieh, L., Greene, G. L., & Nimer, S. D. (1995) · Europe PMC (PubMed Central) · Cited by 399 · see citing works
Fibrates increase human apolipoprotein A-II expression through activation of the peroxisome proliferator-activated receptor.
Vu‐Dac, N., Schoonjans, K., Kosykh, V., Dallongeville, J., Fruchart, J., Staels, B., & Auwerx, J. H. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118118 · Cited by 397 · see citing works
Self-citation
Induction of the Acyl-Coenzyme A Synthetase Gene by Fibrates and Fatty Acids Is Mediated by a Peroxisome Proliferator Response Element in the C Promoter
Schoonjans, K., 渡辺, 光., Suzuki, H., Mahfoudi, A., Krey, G. D., Wahli, W., Grimaldi, P. A., Staels, B., Yamamoto, T. T., & Auwerx, J. H. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.33.19269 · Cited by 395 · see citing works
Self-citation
Adipocyte-specific transcription factor ARF6 is a heterodimeric complex of two nuclear hormone receptors, PPAR7 and RXRa
Tontonoz, P., Graves, R. A., Budavari, A. I., Erdjument‐Bromage, H., Lui, M., Hu, E., Tempst, P., & Spiegelman, B. M. (1994) · Nucleic Acids Research · doi:10.1093/nar/22.25.5628 · Cited by 383 · see citing works
Chicken ovalbumin upstream promoter transcription factor (COUP-TF) dimers bind to different GGTCA response elements, allowing COUP-TF to repress hormonal induction of the vitamin D3, thyroid hormone, and retinoic acid receptors.
Cooney, A. J., Tsai, S. Y., O’Malley, B. W., & Tsai, M. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.9.4153 · Cited by 383 · see citing works
Peroxisome proliferator-activated receptor mediates induction of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene by fatty acids.
Rodríguez, J. C., Gil‐Gómez, G., Hegardt, F. G., & Haro, D. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32234-2 · Cited by 378 · see citing works
Cloning of a new member of the peroxisome proliferator-activated receptor gene family from mouse liver.
Zhu, Y., Alvares, K., Huang, Q. M., Rao, M. S. R., & Reddy, J. K. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)74184-2 · Cited by 374 · see citing works
A Novel Orphan Receptor Specific for a Subset of Thyroid Hormone-Responsive Elements and Its Interaction with the Retinoid/Thyroid Hormone Receptor Subfamily
Apfel, R., Benbrook, D., Lernhardt, E., Ortiz, M. A., Salbert, G., & Pfahl, M. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.10.7025 · Cited by 372 · see citing works
Cloning of a Protein That Mediates Transcriptional Effects of Fatty Acids in Preadipocytes
Amri, E., Bonino, F., Ailhaud, G. P., Abumrad, N. A., & Grimaldi, P. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.5.2367 · Cited by 368 · see citing works
Atherosclerosis in Transgenic Mice Overexpressing Apolipoprotein A-II
Warden, C. H., Hedrick, C. C., Qiao, J.-H., Castellani, L. W., & Lusis, A. J. (1993) · Science · doi:10.1126/science.8332912 · Cited by 359 · see citing works
Structure and regulation of rat long-chain acyl-CoA synthetase.
Suzuki, H., Kawarabayasi, Y., Kondo, J. D. M., Abé, T., Nishikawa, K., Kimura, S., Hashimoto, T., & Yamamoto, T. T. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)38942-2 · Cited by 357 · see citing works
Regulation of Progesterone Receptor-Mediated Transcription by Phosphorylation
Denner, L. A., Weigel, N. L., Maxwell, B. L., Schrader, W. T., & O’Malley, B. W. (1990) · Science · doi:10.1126/science.2176746 · Cited by 356 · see citing works
Biochemical Mechanisms Of Induction Of Hepatic Peroxisome Proliferation
Lock, E. (1989) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.29.1.145 · Cited by 356 · see citing works
Hormone and antihormone induce distinct conformational changes which are central to steroid receptor activation.
Allan, G. F., Leng, X., Tsai, S. Y., Weigel, N. L., Edwards, D. P., Tsai, M., & O’Malley, B. W. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)41805-4 · Cited by 352 · see citing works
Mode of Action of Peroxisome Proliferators as Hypolipidemic Drugs.
Hertz, R., Bishara-Shieban, J., & Bar‐Tana, J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.22.13470 · Cited by 339 · see citing works
Members of the steroid hormone receptor superfamily interact with TFIIB (S300-II).
Ing, N. H., Beekman, J. M., Tsai, S. Y., Tsai, M., & O’Malley, B. W. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)37087-5 · Cited by 336 · see citing works
Interaction of human thyroid hormone receptor beta with transcription factor TFIIB may mediate target gene derepression and activation by thyroid hormone.
Baniahmad, A., Ha, I., Reinberg, D., Tsai, S. Y., Tsai, M., & O’Malley, B. W. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.19.8832 · Cited by 330 · see citing works
Expression of the Peroxisome Proliferator-activated Receptor α Gene Is Stimulated by Stress and Follows a Diurnal Rhythm
Lemberger, T., Saladin, R., Vázquez‐Carrera, M., Assimacopoulos, F., Staels, B., Desvergne, B., Wahli, W., & Auwerx, J. H. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.3.1764 · Cited by 329 · see citing works
Self-citation
Apolipoprotein A-I containing lipoproteins in coronary artery disease
Puchois, P., Kandoussi, A., Fievet, P., Fourrier, J. L., Bertrand, M. E., Koren, E., & Fruchart, J. (1987) · Atherosclerosis · doi:10.1016/0021-9150(87)90091-8 · Cited by 326 · see citing works
Characterization of the ligand‐dependent transactivation domain of thyroid hormone receptor.
Barettino, D., Ruiz, M. M. V., & Stunnenberg, H. G. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06603.x · Cited by 321 · see citing works
Transcriptional regulation of human apolipoprotein genes ApoB, ApoCIII, and ApoAII by members of the steroid hormone receptor superfamily HNF-4, ARP-1, EAR-2, and EAR-3.
Ladias, J. A. A., Hadzopoulou‐Cladaras, M., Kardassis, D., Cardot, P., Cheng, J., Zannis, V. I., & Cladaras, C. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)49613-0 · Cited by 317 · see citing works
Targeted disruption of the apolipoprotein C-III gene in mice results in hypotriglyceridemia and protection from postprandial hypertriglyceridemia.
Maeda, N., Li, H., Lee, D., Oliver, P. M., Quarfordt, S. H., & Osada, J. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31559-4 · Cited by 313 · see citing works
The peroxisome proliferator-activated receptor mediates the induction of CYP4A6, a cytochrome P450 fatty acid omega-hydroxylase, by clofibric acid.
Muerhoff, A. S., Griffin, K. J., & Johnson, E. F. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)41738-3 · Cited by 311 · see citing works
Participation of Non-Zinc Finger Residues in DNA Binding by Two Nuclear Orphan Receptors
Wilson, T. E., Paulsen, R. E., Padgett, K. A., & Milbrandt, J. (1992) · Science · doi:10.1126/science.1314418 · Cited by 310 · see citing works
The peroxisome proliferator-activated receptor:retinoid X receptor heterodimer is activated by fatty acids and fibrate hypolipidaemic drugs
Issemann, I., Prince, R. A., Tugwood, J. D., & Green, S. (1993) · Journal of Molecular Endocrinology · doi:10.1677/jme.0.0110037 · Cited by 307 · see citing works
RARs and RXRs: evidence for two autonomous transactivation functions (AF‐1 and AF‐2) and heterodimerization in vivo.
Nagpal, S., Friant, S., Nakshatri, H., & Chambon, P. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb05889.x · Cited by 300 · see citing works
Identification of two transactlvation domains in the mouse oestrogen receptor
Lees, J. A., Fawell, S. E., & Parker, M. G. (1989) · Nucleic Acids Research · doi:10.1093/nar/17.14.5477 · Cited by 295 · see citing works
The adipocyte: Storage depot or node on the energy information superhighway?
Flier, J. S. (1995) · Cell · doi:10.1016/0092-8674(95)90445-x · Cited by 290 · see citing works
Reciprocal Regulation of Adipogenesis by Myc and C/EBPα
Freytag, S. O., & Geddes, T. J. (1992) · Science · doi:10.1126/science.256.5055.379 · Cited by 286 · see citing works
A Domain Containing Leucine-Zipper-Like Motifs Mediate Novelin VivoInteractions between the Thyroid Hormone and Retinoic Acid Receptors
FORMAN, B. M., Yang, C.-R., Au-Fliegner, M., Casanova, J., Ghysdael, J., & Samuels, H. H. (1989) · Molecular Endocrinology · doi:10.1210/mend-3-10-1610 · Cited by 286 · see citing works
Positive regulation of the peroxisomal β‐oxidation pathway by fatty acids through activation of peroxisome proliferator‐activated receptors (PPAR)
Dreyer, C., Keller, H., Mahfoudi, A., Laudet, V., Krey, G. D., & Wahli, W. (1993) · Biology of the Cell · doi:10.1016/s0248-4900(05)80176-5 · Cited by 284 · see citing works
Metabolic aspects of peroxisomal β-oxidation
Osmundsen, H., Bremer, J., & Pedersen, J. I. (1991) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(91)90089-z · Cited by 281 · see citing works
Protein composition determines the anti-atherogenic properties of HDL in transgenic mice
Schultz, J. R., Verstuyft, J. G., Gong, E. L., Nichols, A. V., & Rubin, E. M. (1993) · Nature · doi:10.1038/365762a0 · Cited by 275 · see citing works
PPAR-RXR Heterodimer Activates a Peroxisome Proliferator Response Element Upstream of the Bifunctional Enzyme Gene
Bardot, O., Aldridge, T. C., Latruffe, N., & Green, S. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.1378 · Cited by 269 · see citing works
Transcriptional activation by the estrogen receptor requires a conformational change in the ligand binding domain
Beekman, J. M., Allan, G. F., Tsai, S. Y., Tsai, M., & O’Malley, B. W. (1993) · Molecular Endocrinology · doi:10.1210/mend.7.10.8264659 · Cited by 260 · see citing works
RZRs, a new family of retinoid-related orphan receptors that function as both monomers and homodimers
Carlberg, C., van Huijsduijnen, R. H., Staple, J. K., DeLamarter, J. F., & Becker-André, M. (1994) · Molecular Endocrinology · doi:10.1210/mend.8.6.7935491 · Cited by 258 · see citing works
Regulation of adipose cell differentiation. I. Fatty acids are inducers of the aP2 gene expression.
Amri, E., Bertrand, B., Ailhaud, G. P., & Grimaldi, P. A. (1991) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41912-1 · Cited by 244 · see citing works
DNA POLYMORPHISM ADJACENT TO HUMAN APOPROTEIN A-1 GENE: RELATION TO HYPERTRIGLYCERIDAEMIA
Rees, A., Stocks, J., Shoulders, C. C., Galton, D. J., & Baralle, F. E. (1983) · The Lancet · doi:10.1016/s0140-6736(83)91440-x · Cited by 241 · see citing works
Negative regulation of the human apolipoprotein A-I promoter by fibrates can be attenuated by the interaction of the peroxisome proliferator-activated receptor with its response element.
Vu‐Dac, N., Schoonjans, K., Laine, B., Fruchart, J., Auwerx, J. H., & Staels, B. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47383-8 · Cited by 240 · see citing works
Self-citation
Multiple mechanisms of chicken ovalbumin upstream promoter transcription factor-dependent repression of transactivation by the vitamin D, thyroid hormone, and retinoic acid receptors.
Cooney, A. J., Leng, X., Tsai, S. Y., O’Malley, B. W., & Tsai, M. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53592-4 · Cited by 239 · see citing works
Regulation of the peroxisome proliferator-activated receptor alpha gene by glucocorticoids.
Lemberger, T., Staels, B., Saladin, R., Desvergne, B., Auwerx, J. H., & Wahli, W. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31420-5 · Cited by 233 · see citing works
Self-citation
Identification of a peroxisome proliferator-responsive element upstream of the gene encoding rat peroxisomal enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase.
Zhang, B., Marcus, S. L., Sajjadi, F. G., Alvares, K., Reddy, J. K., Subramani, S. E., Rachubinski, R. A., & Capone, J. P. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.16.7541 · Cited by 232 · see citing works
An apolipoprotein CIII haplotype protective against hypertriglyceridemia is specified by promoter and 3' untranslated region polymorphisms.
Dammerman, M., Sandkuijl, L. A., Halaas, J. L., Chung, W. K., & Breslow, J. L. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.10.4562 · Cited by 227 · see citing works
Peroxisome proliferator and retinoid signalingpathways co-regulate preadipocyte phenotype and survival.
Chawla, A., & Lazar, M. A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.5.1786 · Cited by 227 · see citing works
Induction of peroxisomal β-oxidation in rat liver by high-fat diets
Neat, C. E., Thomassen, M. S., & Osmundsen, H. (1980) · Biochemical Journal · doi:10.1042/bj1860369 · Cited by 219 · see citing works
Dopamine Activation of an Orphan of the Steroid Receptor Superfamily
Power, R. F., Lydon, J. P., Conneely, O. M., et al. (1991) · Science · doi:10.1126/science.2047861 · Cited by 213 · see citing works
Overexpression of human apolipoprotein C-III in transgenic mice results in an accumulation of apolipoprotein B48 remnants that is corrected by excess apolipoprotein E.
de Silva, H. V., Lauer, S. J., Wang, J., Simonet, W. S., Weisgraber, K. H., Mahley, R. W., & Taylor, J. M. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)42171-5 · Cited by 209 · see citing works
Transcription factor TFIIB and the vitamin D receptor cooperatively activate ligand-dependent transcription.
Blanco, J. C. G., Wang, I. M., Tsai, S. Y., Tsai, M., O’Malley, B. W., Jurutka, P. W., Haussler, M. R., & Ozato, K. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.5.1535 · Cited by 207 · see citing works
A Novel DNA-Binding Motif Abuts the Zinc Finger Domain of Insect Nuclear Hormone Receptor FTZ-F1 and Mouse Embryonal Long Terminal Repeat-Binding Protein
Ueda, H., Sun, G.-C., Murata, T., & Hirose, S. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.12.5667 · Cited by 198 · see citing works
Two -acting regulatory sequences in the peroxisome proliferator-responsive enhancer region of rat acyl-CoA oxidase gene
Osumi, T., Wen, J., & Hashimoto, T. (1991) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(91)91645-s · Cited by 197 · see citing works
Requirement and role of arachidonic acid in the differentiation of pre-adipose cells
Gaillard, D., Négrel, R., Lagarde, M., & Ailhaud, G. P. (1989) · Biochemical Journal · doi:10.1042/bj2570389 · Cited by 179 · see citing works
Relationship between Drosophila gap gene tailless and a vertebrate nuclear receptor Tlx
Yu, R. T., McKeown, M., Evans, R. M., & Umesono, K. (1994) · Nature · doi:10.1038/370375a0 · Cited by 179 · see citing works
Identification of a thyroid hormone response element in the malic enzyme gene.
Petty, K. J., Desvergne, B., Mitsuhashi, T., & Nikodem, V. M. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)39126-4 · Cited by 178 · see citing works
Apolipoprotein C-II and C-III levels in hyperlipoproteinemia
Schonfeld, G., George, P. K., Miller, J. P., Reilly, P., & Witztum, J. L. (1979) · Metabolism · doi:10.1016/0026-0495(79)90004-0 · Cited by 176 · see citing works
A role for fatty acids and liver fatty acid binding protein in peroxisome proliferation?
Issemann, I., Prince, R. A., Tugwood, J. D., & Green, S. (1992) · Biochemical Society Transactions · doi:10.1042/bst0200824 · Cited by 164 · see citing works
Transcriptional control of triglyceride metabolism: fibrates and fatty acids change the expression of the LPL and apo C-III genes by activating the nuclear receptor PPAR
Auwerx, J. H., Schoonjans, K., Fruchart, J., & Staels, B. (1996) · Atherosclerosis · doi:10.1016/0021-9150(96)05854-6 · Cited by 158 · see citing works
Self-citation
Peroxisome proliferator-activated receptors: finding the orphan a home
Green, S., & Wahli, W. (1994) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(94)90294-1 · Cited by 157 · see citing works
Identification of Two mPPAR Related Receptors and Evidence for the Existence of Five Subfamily Members
Chen, F., Law, S. W. T., & O’Malley, B. W. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.2302 · Cited by 155 · see citing works
The peroxisome proliferator activated receptor regulates malic enzyme gene expression.
Castelein, H., Gulick, T., Declercq, P. E., Mannaerts, G. P., Moore, D. D., & Baes, M. I. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47083-4 · Cited by 154 · see citing works
The novel compound NO-1886 increases lipoprotein lipase activity with resulting elevation of high density lipoprotein cholesterol, and long-term administration inhibits atherogenesis in the coronary arteries of rats with experimental atherosclerosis.
Tsutsumi, K., Inoue, Y., Shima, A., Iwasaki, K., Kawamura, M., & Murase, T. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116582 · Cited by 149 · see citing works
Fibrates influence the expression of genes involved in lipoprotein metabolism in a tissue-selective manner in the rat.
Staels, B., van Tol, A., Andreu, T., & Auwerx, J. H. (1992) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.12.3.286 · Cited by 148 · see citing works
Self-citation
Lipoprotein Lipase: Recent Contributions from Molecular Biology
Auwerx, J. H., Leroy, P., & Schoonjans, K. (1992) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408369209114602 · Cited by 148 · see citing works
Self-citation
Familial combined hyperlipidemia and abnormal lipoprotein lipase.
Babirak, S. P., Brown, B. G., & Brunzell, J. D. (1992) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.12.10.1176 · Cited by 146 · see citing works
Dexamethasone and Insulin Demonstrate Marked and Opposite Regulation of the Steady‐State mRNA Level of the Peroxisomal Proliferator‐Activated Receptor (PPAR) in Hepatic Cells
Steineger, H. H., Sørensen, H. N., Tugwood, J. D., Skrede, S., Spydevold, Ø. S., & Gautvik, K. M. (1994) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1994.0967b.x · Cited by 145 · see citing works
Effects of clofibrate, bezafibrate, fenofibrate and probucol on plasma lipolytic enzymes in normolipaemic subjects
Heller, F., & Harvengt, C. (1983) · European Journal of Clinical Pharmacology · doi:10.1007/bf00544015 · Cited by 138 · see citing works
Prostacyclin as a potent effector of adipose-cell differentiation
Négrel, R., Gaillard, D., & Ailhaud, G. P. (1989) · Biochemical Journal · doi:10.1042/bj2570399 · Cited by 136 · see citing works
Suppression of Rat Hepatic Fatty Acid Synthase and S14 Gene Transcription by Dietary Polyunsaturated Fat
Blake, W. L., & Clarke, S. D. (1990) · Journal of Nutrition · doi:10.1093/jn/120.12.1727 · Cited by 135 · see citing works
A novel heterodimerization partner for thyroid hormone receptor. Peroxisome proliferator-activated receptor.
Bogazzi, F., Hudson, L. D., & Nikodem, V. M. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32624-8 · Cited by 133 · see citing works
The effect of human C apolipoproteins on the in vitro hepatic metabolism of triglyceride emulsions in the rat.
Quarfordt, S. H., Michalopoulos, G. K., & Schirmer, B. D. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)33329-5 · Cited by 132 · see citing works
Synergistic Interactions between Transcription Factors Control Expression of the Apolipoprotein AI Gene in Liver Cells
Widom, R. L., Ladias, J. A. A., Kouidou, S., & Karathanasis, S. K. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.2.677 · Cited by 126 · see citing works
A new orphan member of the nuclear hormone receptor superfamily closely related to Rev-Erb
Dumas, B., Harding, H. P., Choi, H.-S., Lehmann, K. A., Chung, M., Lazar, M. A., & Moore, D. D. (1994) · Molecular Endocrinology · doi:10.1210/mend.8.8.7997240 · Cited by 123 · see citing works
Regulation of Rat Liver Apolipoprotein A‐I, Apolipoprotein A‐II and Acyl‐Coenzyme A Oxidase Gene Expression by Fibrates and Dietary Fatty Acids
Berthou, L., Saladin, R., Yaqoob, P., Branellec, D., Calder, P. C., Fruchart, J., Denèfle, P., Auwerx, J. H., & Staels, B. (1995) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1995.tb20797.x · Cited by 119 · see citing works
Self-citation
Serum lipids, hepatic glycerolipid metabolism and peroxisomal fatty acid oxidation in rats fed ω-3 and ω-6 fatty acids
Rustan, A. C., Christiansen, E. N., & Drevon, C. A. (1992) · Biochemical Journal · doi:10.1042/bj2830333 · Cited by 115 · see citing works
Coordinate Suppression of Liver Acetyl-CoA Carboxylase and Fatty Acid Synthetase by Polyunsaturated Fat
Toussant, M. J., Wilson, M. D., & Clarke, S. D. (1981) · Journal of Nutrition · doi:10.1093/jn/111.1.146 · Cited by 114 · see citing works
PEROXISOMAL βT‐OXIDATION OF LONG FATTY ACIDS: EFFECTS OF HIGH FAT DIETS*
Osmundsen, H. (1982) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1982.tb21404.x · Cited by 112 · see citing works
IDENTIFICATION OF NOVEL
LLOYD-BAKER, O. (1964) · Notes and Queries · doi:10.1093/nq/11-7-271g · Cited by 111 · see citing works
A Novel Orphan Receptor Specific for a Subset of Thyroid Hormone-Responsive Elements and Its Interaction with the Retinoid/Thyroid Hormone Receptor Subfamily
Apfel, R., Benbrook, D. M., Lernhardt, E., et al. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.10.7025-7035.1994 · Cited by 110 · see citing works
Acyl‐CoA synthetase mRNA expression is controlled by fibric‐acid derivatives, feeding and liver proliferation
Schoonjans, K., Staels, B., Grimaldi, P. A., & Auwerx, J. H. (1993) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1993.tb18181.x · Cited by 109 · see citing works
Self-citation
Induction of the peroxisome proliferator activated receptor by fenofibrate in rat liver
Gebel, T., Arand, M., & Oesch, F. (1992) · FEBS Letters · doi:10.1016/0014-5793(92)80734-x · Cited by 106 · see citing works
Induction of peroxisomal fatty acid beta-oxidation and liver fatty acid-binding protein by peroxisome proliferators. Mediation via the cytochrome P-450IVA1 omega-hydroxylase pathway
Kaikaus, R. M., Chan, W. K., Lysenko, N., RAY, R. E., de Montellano, P. R. O., & Bass, N. M. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98392-4 · Cited by 104 · see citing works
Xenopus peroxisome proliferator activated receptors: Genomic organization, response element recognition, heterodimer formation with retinoid X receptor and activation by fatty acids
Krey, G. D., Keller, H., Mahfoudi, A., Medin, J. A., Ozato, K., Dreyer, C., & Wahli, W. (1993) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(93)90058-5 · Cited by 104 · see citing works
Independent regulation of plasma apolipoprotein C–II and C–III concentrations in very low density and high density lipoproteins: implications for the regulation of the catabolism of these lipoproteins
Le, N. A., Gibson, J. C., & Ginsberg, H. N. (1988) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38512-6 · Cited by 103 · see citing works
Chicken ovalbumin upstream promoter transcription factor (COUP-TF) binds to a peroxisome proliferator-responsive element and antagonizes peroxisome proliferator-mediated signaling.
Miyata, K., Zhang, B., Marcus, S. L., Capone, J. P., & Rachubinski, R. A. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)36491-9 · Cited by 101 · see citing works
Activation of hypolipidaemic drugs to acyl-coenzyme A thioesters
Bronfman, M., Amigo, L., & Morales, M. N. (1986) · Biochemical Journal · doi:10.1042/bj2390781 · Cited by 96 · see citing works
Promiscuous liaisons
Green, S. (1993) · Nature · doi:10.1038/361590a0 · Cited by 96 · see citing works
Peroxisome proliferator-binding protein: identification and partial characterization of nafenopin-, clofibric acid-, and ciprofibrate-binding proteins from rat liver.
Lalwani, N. D., Alvares, K., Reddy, M. K., Reddy, M. N., Parikh, I., & Reddy, J. K. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.15.5242 · Cited by 95 · see citing works
Apolipoproteins C-II and C-III metabolism in hypertriglyceridemic patients Effect of a drastic triglyceride reduction by combined diet restriction and fenofibrate administration
Malmendier, C. L., Lontie, J., Delcroix, C., Dubois, D. Y., Magot, T., & Roy, L. D. (1989) · Atherosclerosis · doi:10.1016/0021-9150(89)90075-0 · Cited by 94 · see citing works
How to finger DNA
Gronemeyer, H., & Moras, D. (1995) · Nature · doi:10.1038/375190a0 · Cited by 91 · see citing works
A Pleiotropic Element in the Medium-Chain Acyl Coenzyme A Dehydrogenase Gene Promoter Mediates Transcriptional Regulation by Multiple Nuclear Receptor Transcription Factors and Defines Novel Receptor-DNA Binding Motifs
Carter, M. E., Gulick, T., Moore, D. D., & Kelly, D. P. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.7.4360-4372.1994 · Cited by 87 · see citing works
Effects of fenofibrate on high and low density lipoprotein metabolism in heterozygous familial hypercholesterolemia
Malmendier, C. L., & Delcroix, C. (1985) · Atherosclerosis · doi:10.1016/0021-9150(85)90095-4 · Cited by 85 · see citing works
Interaction of the peroxisome proliferator-activated receptor alpha with the retinoid X receptor alpha unmasks a cryptic peroxisome proliferator response element that overlaps an ARP-1-binding site in the CYP4A6 promoter.
Palmer, C. N., Hsu, M., Muerhoff, A. S., Griffin, K. J., & Johnson, E. F. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32420-1 · Cited by 83 · see citing works
Analysis of Acyl Coenzyme A Binding to the Transcription Factor FadR and Identification of Amino Acid Residues in the Carboxyl Terminus Required for Ligand Binding
Raman, N., & Dirusso, C. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.3.1092 · Cited by 83 · see citing works
On the mechanism of induction of the enzyme systems for peroxisomal β-oxidation of fatty acids in rat liver by diets rich in partially hydrogenated fish oil
Flatmark, T., Nilsson, A., Kvannes, J., Eikhom, T. S., Fukami, M. H., Kryvi, H., & Christiansen, E. N. (1988) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(88)90103-8 · Cited by 81 · see citing works
Characterization of protein-DNA interactions within the peroxisome proliferator-responsive element of the rat hydratase-dehydrogenase gene
Zhang, B., Marcus, S. L., Miyata, K., Subramani, S. E., Capone, J. P., & Rachubinski, R. A. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)31476-5 · Cited by 79 · see citing works
cDNA cloning and characterization of the transcriptional activities of the hamster peroxisome proliferator-activated receptor haPPARγ
Aperlo, C., Pognonec, P., Saladin, R., Auwerx, J. H., & Boulukos, K. E. (1995) · Gene · doi:10.1016/0378-1119(95)00196-d · Cited by 79 · see citing works
Self-citation
On the Mode of Action of Lipid-lowering Agents
Maragoudakis, M. E., & Hankin, H. (1971) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)62498-6 · Cited by 77 · see citing works
The ontogeny of peroxisome-proliferator-activated receptor gene expression in the mouse and rat
Beck, F., Plummer, S., Senior, P. V., Byrne, S., Green, S., & Brammar, W. J. (1992) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1992.0012 · Cited by 77 · see citing works
Peroxisome proliferating sulphur- and oxy-substituted fatty acid analogues are activated to acyl coenzyme a thioesters
Aarsland, A. A., & Berge, R. K. (1991) · Biochemical Pharmacology · doi:10.1016/0006-2952(91)90010-3 · Cited by 76 · see citing works
A multicenter comparison of the effects of simvastatin and fenofibrate therapy in severe primary hypercholesterolemia, with particular emphasis on lipoproteins defined by their apolipoprotein composition
Bard, J., Parra, H. J., Camaré, R., Luc, G., Ziegler, O., Dachet, C., Bruckert, É., DOUSTE‐BLAZY, P., Drouin, P., JACOTOT, B., et al. (1992) · Metabolism · doi:10.1016/0026-0495(92)90208-r · Cited by 76 · see citing works
Perturbation of developmental gene expression in rat liver by fibric acid derivatives: lipoprotein lipase and α-fetoprotein as models
Staels, B., & Auwerx, J. H. (1992) · Development · doi:10.1242/dev.115.4.1035 · Cited by 76 · see citing works
Self-citation
Effect of diabetes and starvation on the activity of rat liver epoxide hydrolases, glutathione S-transferases and peroxisomal β-oxidation
Thomas, H., Schladt, L., Knehr, M., et al. (1989) · Biochemical Pharmacology · doi:10.1016/0006-2952(89)90528-5 · Cited by 75 · see citing works
Apolipoprotein A-II Production Rate Is a Major Factor Regulating the Distribution of Apolipoprotein A-I Among HDL Subclasses LpA-I and LpA-I:A-II in Normolipidemic Humans
Ikewaki, K., Zech, L. A., Kindt, M. R., Brewer, H. B., & Rader, D. J. (1995) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.15.3.306 · Cited by 71 · see citing works
The Drosophila nuclear receptors FTZ-F1 alpha and FTZ-F1 beta compete as monomers for binding to a site in the fushi tarazu gene.
Ohno, C. K., Ueda, H., & Petkovich, M. P. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.5.3166 · Cited by 69 · see citing works
Structure of the Mouse Peroxisome Proliferator Activated Receptor α Gene
Gearing, K. L., Crickmore, A., & Gustafsson, J.-Α. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.1222 · Cited by 68 · see citing works
Hepatocyte nuclear factor-4 activates medium chain acyl-CoA dehydrogenase gene transcription by interacting with a complex regulatory element
Carter, M. E., Gulick, T., Raisher, B. D., Caira, T., Ladias, J. A. A., Moore, D. D., & Kelly, D. P. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)85174-8 · Cited by 63 · see citing works
Alteration of lipid profiles in plasma of transgenic mice expressing human lipoprotein lipase
Min, L. I. U., Jirik, F. R., LeBoeuf, R. C., Henderson, H., Castellani, L. W., Lusis, A. J., Ma, Y., Forsythe, I. J., Zhang, H., & Kirk, E. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)78140-x · Cited by 61 · see citing works
Identification of a novel retinoid-responsive element in the promoter region of the medium chain acyl-coenzyme A dehydrogenase gene.
Raisher, B. D., Gulick, T., Zhang, Z., Strauss, A. W., Moore, D. D., & Kelly, D. P. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)88695-7 · Cited by 57 · see citing works
Peroxisomes in liver, heart, and kidney of mice fed a commercial fish oil preparation: original data and review on peroxisomal changes induced by high-fat diets.
Craemer, D. D., Vamecq, J., Roels, F., Vallée, L., Pauwels, M., & Branden, C. V. D. (1994) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39967-3 · Cited by 57 · see citing works
Stimulation of fatty acid oxidation by a 3-thia fatty acid reduces triacylglycerol secretion in cultured rat hepatocytes.
Skrede, S., Bremer, J., Berge, R. K., & Rustan, A. C. (1994) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)40081-1 · Cited by 56 · see citing works
A Novel DNA-Binding Motif Abuts the Zinc Finger Domain of Insect Nuclear Hormone Receptor FTZ-F1 and Mouse Embryonal Long Terminal Repeat-Binding Protein
Ueda, H., Sun, G.-C., Murata, T., et al. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.12.5667-5672.1992 · Cited by 53 · see citing works
Lipoprotein composition changes induced by fenofibrate in dysbetalipoproteinemia type III
Lussier‐Cacan, S., Bard, J., Boulet, L., Nestruck, A. C., Grothé, A.-M., Fruchart, J., & Davignon, J. (1989) · Atherosclerosis · doi:10.1016/0021-9150(89)90221-9 · Cited by 52 · see citing works
PPAR: a Key Nuclear Factor in Nutrient / Gene Interactions?
Desvergne, B., & Wahli, W. (1995) · Birkhäuser Boston eBooks · doi:10.1007/978-1-4684-6840-3_5 · Cited by 51 · see citing works
The effects of alkylthioacetic acids (3-thia fatty acids) on fatty acid metabolism in isolated hepatocytes
Skrede, S., Narce, M., Bergseth, S., & Bremer, J. (1989) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(89)90052-0 · Cited by 49 · see citing works
HYPERTRIGLYCERIDÆMIA ASSOCIATED WITH AN ABNORMAL TRIGLYCERIDE-RICH LIPOPROTEIN CARRYING EXCESS APOLIPOPROTEIN C-III-2
Stocks, J., Holdsworth, G., & Galton, D. (1979) · The Lancet · doi:10.1016/s0140-6736(79)92068-3 · Cited by 48 · see citing works
Fibric acid derivatives
Tikkanen, M. J. (1992) · Current Opinion in Lipidology · doi:10.1097/00041433-199202000-00006 · Cited by 47 · see citing works
Nuclear Receptors: Lonesome orphans
Laudet, V., & Adelmant, G. (1995) · Current Biology · doi:10.1016/s0960-9822(95)00031-5 · Cited by 46 · see citing works
Effects of fenofibrate on lipids, lipoproteins, and apolipoproteins in 33 subjects with primary hypercholesterolemia
Mellies, M. J., Stein, E. A., Khoury, P., Lamkin, G., & Glueck, C. J. (1987) · Atherosclerosis · doi:10.1016/0021-9150(87)90082-7 · Cited by 44 · see citing works
Modulation of rat liver peroxisomal and microsomal fatty acid oxidation by starvation
Orellana, M., Fuentes, O., Rosenbluth, H., et al. (1992) · FEBS Letters · doi:10.1016/0014-5793(92)81327-i · Cited by 43 · see citing works
Transcriptional activation by amphipathic carboxylic peroxisomal proliferators is induced by the free acid rather than the acyl‐CoA derivative
Hertz, R., Berman, I., & Bar‐Tana, J. (1994) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1994.tb18773.x · Cited by 40 · see citing works
Pretranslational regulation of the expression of the lipoprotein lipase (EC3.1, l.34) gene by dietary fatty acids in the rat
Murphy, M. C., Zampelas, A., Puddicombe, S. M., Furlonger, N., Morgan, L., & Williams, C. M. (1993) · British Journal Of Nutrition · doi:10.1079/bjn19930168 · Cited by 40 · see citing works
Hepatic Fatty Acid Metabolism as a Determinant of Plasma and Liver Triacylglycerol Levels
Asiedu, D. K., Al‐Shurbaji, A., Rustan, A. C., Björkhem, I., Berglund, L., & Berge, R. K. (1995) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1995.0715p.x · Cited by 39 · see citing works
Factors participating in the liver-specific expression of the human apolipoprotein A-II gene and their significance for transcription
Cardot, P., Chambaz, J., Kardassis, D., et al. (1993) · Biochemistry · doi:10.1021/bi00086a013 · Cited by 39 · see citing works
Hepatic Fatty Acid Metabolism as a Determinant of Plasma and Liver Triacylglycerol Levels. Studies on Tetradecylthioacetic and Tetradecylthiopropionic Acids
Asiedu, D. K., Al‐Shurbaji, A., Rustan, A. C., et al. (1995) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1995.tb20193.x · Cited by 38 · see citing works
On the Mode of Action of Lipid-lowering Agents
Maragoudakis, M. E. (1971) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)62138-6 · Cited by 35 · see citing works
Hypolipidemic effect of beta, beta'-methyl-substituted hexadecanedioic acid (MEDICA 16) in normal and nephrotic rats.
Bar‐Tana, J., Rose-Kahn, G., Frenkel, B., Schafer, Z., & FAINARU, M. (1988) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38517-5 · Cited by 35 · see citing works
An enzymatic explanation of the differential effects of oleate and gemfibrozil on cultured hepatocyte triacylglycerol and phosphatidylcholine biosynthesis and secretion
Lamb, R. G., Koch, J. C., & Bush, S. R. (1993) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(93)90140-5 · Cited by 33 · see citing works
Beneficial effects of fish-oil supplements on lipids, lipoproteins, and lipoprotein lipase in patients with glycogen storage disease type l
Levy, E. H., Thibault, L., Turgeon, J. P., ROY, C. C., Gurbindo, C., Lepage, G., Godard, M., Rivard, G., & Seidman, E. G. (1993) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/57.6.922 · Cited by 29 · see citing works
Adipocyte conversion of cultured 3T3-Ll preadipocytes by bezafibrate
Brandes, R., Hertz, R., Arad, R., et al. (1987) · Life Sciences · doi:10.1016/0024-3205(87)90312-2 · Cited by 26 · see citing works
The effect of β,β'-tetramethylhexadecanedioic acid (MEDICA 16) on plasma very-low-density lipoprotein metabolism in rats: role of apolipoprotein C-III
Frenkel, B., Bishara-Shieban, J., & Bar‐Tana, J. (1994) · Biochemical Journal · doi:10.1042/bj2980409 · Cited by 25 · see citing works
Triglyceride-lowering agents: fibrates and nicotinic acid
Larsen, M. L., & Illingworth, D. R. (1993) · Current Opinion in Lipidology · doi:10.1097/00041433-199302000-00007 · Cited by 25 · see citing works
Identification of a Novel Member of the Nuclear Receptor Superfamily Which Is Closely Related to Rev-ErbA
Enmark, E., Kainu, T., Pelto‐Huikko, M., et al. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.2424 · Cited by 22 · see citing works
Tissue selective modulation of redox and phosphate potentials by beta,beta'-methyl-substituted hexadecanedioic acid.
Kalderon, B., Hertz, R., & Bar‐Tana, J. (1992) · Endocrinology · doi:10.1210/endo.131.4.1396307 · Cited by 21 · see citing works
Increase of adipose differentiation by hypolipidemic fibrate drugs in Ob 17 preadipocytes: Requirement for thyroid hormones
GHARBI-CHIHI, J., Teboul, M., Bismuth, J., Bonne, J., & Torrésani, J. (1993) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/0167-4889(93)90150-n · Cited by 20 · see citing works
Thyromimetic effect of peroxisome proliferators
Hertz, R., Kalderon, B., & Bar‐Tana, J. (1993) · Biochimie · doi:10.1016/0300-9084(93)90085-7 · Cited by 19 · see citing works
Toxicity of peroxisome proliferators
Bieri, F., & Lhuguenot, J. (1993) · Biochimie · doi:10.1016/0300-9084(93)90086-8 · Cited by 9 · see citing works
Transcriptional activation of the estrogen receptor
Wei, L. L. (1993) · Clinical Chemistry · doi:10.1093/clinchem/39.2.341 · Cited by 8 · see citing works

Flagged first, then by citations

Sorted by citations

Ecotoxicology of human pharmaceuticals
Fent, K., Weston, A. A., & Caminada, D. (2006) · Aquatic Toxicology · doi:10.1016/j.aquatox.2005.09.009 · Cited by 3,223 · see citing works
The mechanisms of action of PPARs
Berger, J., & Moller, D. E. (2002) · Annual Review of Medicine · doi:10.1146/annurev.med.53.082901.104018 · Cited by 2,659 · see citing works
Mechanism of Action of Fibrates on Lipid and Lipoprotein Metabolism
Staels, B., Dallongeville, J., Auwerx, J., Schoonjans, K., Leitersdorf, E., & Fruchart, J.-C. (1998) · Circulation · doi:10.1161/01.cir.98.19.2088 · Cited by 1,786 · see citing works
Self-citation
Peroxisome proliferator–activated receptor α mediates the adaptive response to fasting
Kersten, S., Seydoux, J., Peters, J. M., Gonzalez, F. J., Desvergne, B., & Wahli, W. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6223 · Cited by 1,649 · see citing works
Thematic review series: The Pathogenesis of Atherosclerosis. Effects of infection and inflammation on lipid and lipoprotein metabolism mechanisms and consequences to the host
Khovidhunkit, W., Kim, M.-S., Memon, R. A., Shigenaga, J. K., Moser, A. H., Feingold, K. R., & Grunfeld, C. (2004) · Journal of Lipid Research · doi:10.1194/jlr.r300019-jlr200 · Cited by 1,481 · see citing works
Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017
Kinoshita, M., Yokote, K., Arai, H., Iida, M., Ishigaki, Y., Ishibashi, S., Umemoto, S., Egusa, G., Ohmura, H., Okamura, T., et al. (2018) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.gl2017 · Cited by 813 · see citing works
PPARγ, the ultimate thrifty gene
Auwerx, J. (1999) · Diabetologia · doi:10.1007/s001250051268 · Cited by 612 · see citing works
Self-citation
Coordinate Regulation of the Expression of the Fatty Acid Transport Protein and Acyl-CoA Synthetase Genes by PPARα and PPARγ Activators
Martin, G., Schoonjans, K., Lefebvre, A.-M., Staels, B., & Auwerx, J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.45.28210 · Cited by 551 · see citing works
Self-citation
Targeting Sirtuin 1 to Improve Metabolism: All You Need Is NAD+?
Cantó, C., & Auwerx, J. (2012) · Pharmacological Reviews · doi:10.1124/pr.110.003905 · Cited by 433 · see citing works
Self-citation
Improved Glycemic Control and Enhanced Insulin Sensitivity in Type 2 Diabetic Subjects Treated With Pioglitazone
Miyazaki, Y., Mahankali, A., Matsuda, M., Glass, L., Mahankali, S., Ferrannini, E., Cusi, K., Mandarino, L. J., & DeFronzo, R. A. (2001) · Diabetes Care · doi:10.2337/diacare.24.4.710 · Cited by 407 · see citing works
Skeletal Muscle as an Endocrine Organ: The Role of Myokines in Exercise Adaptations
Hoffmann, C., & Weigert, C. (2017) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a029793 · Cited by 393 · see citing works
Pharmacological approaches to restore mitochondrial function
Andreux, P. A., Houtkooper, R. H., & Auwerx, J. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd4023 · Cited by 383 · see citing works
Self-citation
Steatohepatitis, Spontaneous Peroxisome Proliferation and Liver Tumors in Mice Lacking Peroxisomal Fatty Acyl-CoA Oxidase
Fan, C.-Y., Pan, J., Usuda, N., Yeldandi, A. V., Rao, M. S., & Reddy, J. K. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.25.15639 · Cited by 343 · see citing works
The role of PPARα in lipid metabolism and obesity: Focusing on the effects of estrogen on PPARα actions
Yoon, M. (2009) · Pharmacological Research · doi:10.1016/j.phrs.2009.02.004 · Cited by 336 · see citing works
Fibrates and cholestasis
Ghonem, N. S., Assis, D. N., & Boyer, J. L. (2015) · Hepatology · doi:10.1002/hep.27744 · Cited by 317 · see citing works
Regulation of Ketone Body Metabolism and the Role of PPARα
Grabacka, M., Pierzchalska, M., Dean, M., & Reiss, K. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17122093 · Cited by 305 · see citing works
Activation of PPARδ alters lipid metabolism in db/db mice
Leibowitz, M. D., Fiévet, C., Hennuyer, N., Peinado-Onsurbe, J., Duez, H., Berger, J., Cullinan, C. A., Sparrow, C. P., Baffic, J., Berger, G. D., et al. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01554-4 · Cited by 308 · see citing works
Self-citation
Apolipoprotein C-III: understanding an emerging cardiovascular risk factor
Ooi, E. M. M., Barrett, P. H. R., Chan, D. C., & Watts, G. F. (2008) · Clinical Science · doi:10.1042/cs20070308 · Cited by 282 · see citing works
Expression and nutritional regulation of lipogenic genes in the ruminant lactating mammary gland
Bernard, L., Leroux, C., & Chilliard, Y. (2007) · Advances in Experimental Medicine and Biology · doi:10.1007/978-0-387-74087-4_2 · Cited by 249 · see citing works
Effect of DHEA on Abdominal Fat and Insulin Action in Elderly Women and Men: A Randomized Controlled Trial
Villareal, D. T., & Holloszy, J. O. (2004) · JAMA · doi:10.1001/jama.292.18.2243 · Cited by 241 · see citing works
Niacin and fibrates in atherogenic dyslipidemia: pharmacotherapy to reduce cardiovascular risk
Chapman, M. J., Redfern, J. S., McGovern, M. E., & Giral, P. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.01.008 · Cited by 227 · see citing works
Fission and proliferation of peroxisomes
Schrader, M., Bonekamp, N. A., & Islinger, M. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.12.014 · Cited by 189 · see citing works
Pilot study: fenofibrate for patients with primary biliary cirrhosis and an incomplete response to ursodeoxycholic acid: Pilot study: fenofibrate with UDCA for primary biliary cirrhosis
Levy, C., Peter, J. A., Nelson, D. R., Keach, J., Petz, J., Cabrera, R., Clark, V., Firpi, R. J., Morelli, G., Soldevila-Pico, C., et al. (2011) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2010.04512.x · Cited by 186 · see citing works
Obesity, Peroxisome Proliferator-Activated Receptor, and Atherosclerosis in Type 2 Diabetes
Blaschke, F., Takata, Y., Caglayan, E., Law, R. E., & Hsueh, W. A. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000191663.12164.77 · Cited by 176 · see citing works
Severe Atherosclerosis and Hypoalphalipoproteinemia in the Staggerer Mouse, a Mutant of the Nuclear Receptor RORα
Mamontova, A., Séguret-Macé, S., Esposito, B., Chaniale, C., Bouly, M., Delhaye-Bouchaud, N., Luc, G., Staels, B., Duverger, N., Mariani, J., et al. (1998) · Circulation · doi:10.1161/01.cir.98.24.2738 · Cited by 172 · see citing works
Self-citation
Fenofibrate: A Review of its Use in Primary Dyslipidaemia, the Metabolic Syndrome and Type 2 Diabetes Mellitus
Keating, G. M., & Croom, K. F. (2007) · Drugs · doi:10.2165/00003495-200767010-00013 · Cited by 169 · see citing works
Fibrates Suppress Fibrinogen Gene Expression in Rodents Via Activation of the Peroxisome Proliferator-Activated Receptor-
Kockx, M., Gervois, P. P., Poulain, P., Derudas, B., Peters, J. M., Gonzalez, F. J., Princen, H. M. G., Kooistra, T., & Staels, B. (1999) · Blood · doi:10.1182/blood.v93.9.2991 · Cited by 139 · see citing works
Self-citation
Effects of Bezafibrate on Outcome and Pruritus in Primary Biliary Cholangitis With Suboptimal Ursodeoxycholic Acid Response
Reig, A., Sesé, P., & Parés, A. (2018) · American Journal of Gastroenterology · doi:10.1038/ajg.2017.287 · Cited by 115 · see citing works
Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study: baseline characteristics and short-term effects of fenofibrate [ISRCTN64783481]
The FIELD Study Investigators (2005) · Cardiovascular Diabetology · doi:10.1186/1475-2840-4-13 · Cited by 103 · see citing works
Transcriptome Analysis of K-877 (a Novel Selective PPARα Modulator (SPPARMα))-Regulated Genes in Primary Human Hepatocytes and the Mouse Liver
Raza-Iqbal, S., Tanaka, T., Anai, M., Inagaki, T., Matsumura, Y., Ikeda, K., Taguchi, A., Gonzalez, F. J., Sakai, J., & Kodama, T. (2015) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.28720 · Cited by 100 · see citing works
Fenofibrate for patients with asymptomatic primary biliary cirrhosis
Dohmen, K., Mizuta, T., Nakamuta, M., Shimohashi, N., Ishibashi, H., & Yamamoto, K. (2004) · World Journal of Gastroenterology · doi:10.3748/wjg.v10.i6.894 · Cited by 99 · see citing works
Response to Carbohydrate and Fat Refeeding in the Expression of Genes Involved in Nutrient Partitioning and Metabolism: Striking Effects on Fibroblast Growth Factor-21 Induction
Sánchez, J., Palou, A., & Picó, C. (2009) · Endocrinology · doi:10.1210/en.2009-0466 · Cited by 98 · see citing works
The Effect of HMG-CoA Reductase Inhibitors on Coenzyme Q10: Possible Biochemical/Clinical Implications
Hargreaves, I. P., Duncan, A. J., Heales, S. J. R., & Land, J. M. (2005) · Drug Safety · doi:10.2165/00002018-200528080-00002 · Cited by 91 · see citing works
Exercise, sex, menstrual cycle phase, and 17β-estradiol influence metabolism-related genes in human skeletal muscle
Fu, M.-H. H., Maher, A. C., Hamadeh, M. J., Ye, C., & Tarnopolsky, M. A. (2009) · Physiological Genomics · doi:10.1152/physiolgenomics.00115.2009 · Cited by 90 · see citing works
Molecular Nutrition Research—The Modern Way Of Performing Nutritional Science
Norheim, F., Gjelstad, I., Hjorth, M., Vinknes, K., Langleite, T., Holen, T., Jensen, J., Dalen, K., Karlsen, A., Kielland, A., et al. (2012) · Nutrients · doi:10.3390/nu4121898 · Cited by 83 · see citing works
Fenofibrate modifies transaminase gene expression via a peroxisome proliferator activated receptor α-dependent pathway
Edgar, A. D., Tomkiewicz, C., Costet, P., Legendre, C., Aggerbeck, M., Bouguet, J., Staels, B., Guyomard, C., Pineau, T., & Barouki, R. (1998) · Toxicology Letters · doi:10.1016/s0378-4274(98)00042-3 · Cited by 71 · see citing works
Self-citation
Fibrate induction of the adrenoleukodystrophy‐related gene (ABCD2): Promoter analysis and role of the peroxisome proliferator‐activated receptor PPARα
Fourcade, S., Savary, S., Albet, S., Gauthé, D., Gondcaille, C., Pineau, T., Bellenger, J., Bentejac, M., Holzinger, A., Berger, J., et al. (2001) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2001.02249.x · Cited by 70 · see citing works
PPARα Mediates Transcriptional Upregulation of Novel Organic Cation Transporters-2 and -3 and Enzymes Involved in Hepatic Carnitine Synthesis
Koch, A., König, B., Stangl, G. I., & Eder, K. (2008) · Experimental Biology and Medicine · doi:10.3181/0706-rm-168 · Cited by 61 · see citing works
Supplementation with the reduced form of Coenzyme Q10 decelerates phenotypic characteristics of senescence and induces a peroxisome proliferator‐activated receptor‐α gene expression signature in SAMP1 mice
Schmelzer, C., Kubo, H., Mori, M., Sawashita, J., Kitano, M., Hosoe, K., Boomgaarden, I., Döring, F., & Higuchi, K. (2010) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200900155 · Cited by 53 · see citing works
The effects of omega-3 fatty acids in type 2 diabetes: A systematic review and meta-analysis
Xiao, Y., Zhang, Q., Liao, X., Elbelt, U., & Weylandt, K. H. (2022) · Prostaglandins, Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2022.102456 · Cited by 50 · see citing works
Apolipoprotein C-III, n-3 polyunsaturated fatty acids, and “insulin-resistant” T-455C APOC3 gene polymorphism in heart disease patients: example of gene-diet interaction
Olivieri, O., Martinelli, N., Sandri, M., Bassi, A., Guarini, P., Trabetti, E., Pizzolo, F., Girelli, D., Friso, S., Pignatti, P. F., et al. (2005) · Clinical Chemistry · doi:10.1373/clinchem.2004.040477 · Cited by 50 · see citing works
Beyond LDL-C: unravelling the residual atherosclerotic cardiovascular disease risk landscape—focus on hypertriglyceridaemia
Bashir, B., Schofield, J., Downie, P., France, M., Ashcroft, D. M., Wright, A. K., Romeo, S., Gouni-Berthold, I., Maan, A., Durrington, P. N., et al. (2024) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2024.1389106 · Cited by 40 · see citing works
Triglyceride-lowering Effect of Respiratory Uncoupling in White Adipose Tissue
Rossmeisl, M., Kovar, J., Syrovy, I., Flachs, P., Bobkova, D., Kolar, F., Poledne, R., & Kopecky, J. (2005) · Obesity Research · doi:10.1038/oby.2005.96 · Cited by 23 · see citing works
Effects of Switching from Fenofibrate to Pemafibrate for Asymptomatic Primary Biliary Cholangitis
Dohmen, K., Onohara, S.-Y., & Harada, S. (2021) · The Korean Journal of Gastroenterology · doi:10.4166/kjg.2021.092 · Cited by 18 · see citing works
Effects of increases in dietary fat intake on plasma lipid and lipoprotein cholesterol concentrations and associated enzyme activities in cats
Butterwick, R. F., Salt, C., & Watson, T. D. G. (2012) · American Journal of Veterinary Research · doi:10.2460/ajvr.73.1.62 · Cited by 6 · see citing works

Identification of Peroxisome Proliferator-responsive Human Genes by Elevated Expression of the Peroxisome Proliferator-activated Receptor α in HepG2 Cells
Hsu, M., Savas, Ü., Griffin, K. J., & Johnson, E. F. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100258200 · Cited by 172 · see citing works
Analysis of the constitutively active peroxisome proliferator-activated receptor-γ (PPARγ/Pparg)-dependent transcriptome in MCF10A cells
Tian, L. (2015) · Signaling Pathways Project Datasets · doi:10.1621/ybpnd7v8ht
Peroxisome Proliferator-activated Receptor γ Ligands Differentially Modulate Muscle Cell Differentiation and MyoD Gene Expression via Peroxisome Proliferator-activated Receptor γ-dependent and -independent Pathways
Hunter, J. G., van Delft, M. F., Rachubinski, R. A., & Capone, J. P. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103594200 · Cited by 45 · see citing works
Peroxisome proliferator-activated receptors and cardionephric disease
Wang, R. (2005) · Chinese Journal of Cardiovascular Medicine
Analysis of the peroxisome proliferator activated receptor-δ (PPARδ/Ppard)-regulated transcriptome in mouse skeletal muscle
Burkart-Hartman, E. (2015) · Signaling Pathways Project Datasets · doi:10.1621/qvt5zb9jyh

Authors: Schoonjans, K., Staels, B., & Auwerx, J.
Affiliations: Inserm (FR)
ORCID: Schoonjans, K
Staels, B
Auwerx, J
Venue: Journal of Lipid Research
Publisher: Elsevier BV
Published: 1996-05
Volume: 37
Issue: 5
Pages: 907-925
ISSN: 0022-2275 (ISSN-L)
DOI: 10.1016/s0022-2275(20)42003-6
OpenAlex: W2140038597
Cited by: 1,216
References: 198
Citations by year: 2026: 9 · 2025: 18 · 2024: 9 · 2023: 14 · 2022: 21 · 2021: 21 · 2020: 27 · 2019: 22 · 2018: 31 · 2017: 35 · 2016: 32 · 2015: 43 · 2014: 34 · 2013: 42 · 2012: 32
FWCI: 20.26
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 8929 d)
Locations: Journal of Lipid Research (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Keywords: peroxisome proliferator-activated receptors, PPARα, PPARδ, PPARγ, fibrates, fatty acids, retinoid X receptor, peroxisome proliferator response element, HDL cholesterol, apolipoprotein A-I, apolipoprotein A-II, lipoprotein lipase, apolipoprotein C-III, fatty acid transporters, acyl-CoA synthetase, peroxisomal beta-oxidation, mitochondrial beta-oxidation, VLDL secretion, triglyceride-rich lipoproteins, hypotriglyceridemic effect, adipogenesis, thiazolidinediones, prostaglandin J2
MeSH terms: Animals, Hypolipidemic Agents, Cell Differentiation, Fatty Acids, Gene Expression Regulation, Humans, Transcription Factors, Adipocytes, Receptors, Cytoplasmic and Nuclear, Lipid Metabolism

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks