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Fingerprinting genomes using PCR with arbitrary primers
Open accessAbstract
Simple and reproducible fingerprints of complex genomes can be generated using single arbitrarily chosen primers and the polymerase chain reaction (PCR). No prior sequence information is required. The method, arbitrarily primed PCR (AP-PCR), involves two cycles of low stringency amplification followed by PCR at higher stringency. We show that strains can be distinguished by comparing polymorphisms in genomic fingerprints. The generality of the method is demonstrated by application to twenty four strains from five species of Staphylococcus, eleven strains of Streptococcus pyogenes and three varieties of Oryza sativa (rice).
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Cited by
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Short-sequence DNA repeats in prokaryotic genomes
van Belkum, A., Scherer, S., van Alphen, L., & Verbrugh, H. (1998) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.62.2.275-293.1998 · Cited by 737
Somaclonal Variation in Plants: Causes and Detection Methods
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Metadata
- Authors
- Welsh, J., & McClelland, M.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 1990
- Volume
- 18
- Issue
- 24
- Pages
- 7213-7218
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W1963953102
- Cited by
- 5,150
- References
- 0
- FWCI
- 36.74
- Type
- journal article
- Language
- en
- Open access
- green
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