The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Eukaryotic start and stop translation sites
Open accessAbstract
Sequences flanking translational initiation and termination sites have been compiled and statistically analyzed for various eukaryotic taxonomic groups. A few key similarities between taxonomic groups support conserved mechanisms of initiation and termination. However, a high degree of sequence variation at these sites within and between various eukaryotic groups suggest that translation may be modulated for many mRNAs. Multipositional analysis of di-, tri-, and quadrinucleotide sequences flanking start/stop sites indicate significant biases. In particular, strong tri-nucleotide biases are observed at the -3, -2, and -1 positions upstream of the start codon. These biases and the interspecific variation in nucleotide preferences at these three positions have lead us to propose a revised model of the interaction of the 18S ribosomal RNA with the mRNA at the site of translation initiation. Unusually strong biases against the CG dinucleotide immediately downstream of termination codons suggest that they may lead to faulty termination and/or failure of the ribosome to disassociate from the mRNA.
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Kozak, M. (1986) · Cell · doi:10.1016/0092-8674(86)90762-2 · Cited by 4,741
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Lee, J. J., von Kessler, D. P., Parks, S., & Beachy, P. A. (1992) · Cell · doi:10.1016/0092-8674(92)90264-d · Cited by 581
Translational termination efficiency in mammals is influenced by the base following the stop codon
McCaughan, K. K., Brown, C. M., Dalphin, M. E., Berry, M. J., & Tate, W. P. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.12.5431 · Cited by 284
Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2
Kavanaugh, W. M., Pot, D. A., Chin, S. M., Deuter-Reinhard, M., Jefferson, A. B., Norris, F. A., Masiarz, F. R., Cousens, L. S., Majerus, P. W., & Williams, L. T. (1996) · Current Biology · doi:10.1016/s0960-9822(02)00511-0 · Cited by 217
Cuperus, J. T., Groves, B., Kuchina, A., Rosenberg, A. B., Jojic, N., Fields, S., & Seelig, G. (2017) · Genome Research · doi:10.1101/gr.224964.117 · Cited by 205
Metadata
- Authors
- Cavener, D. R., & Ray, S. C.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 1991
- Volume
- 19
- Issue
- 12
- Pages
- 3185-3192
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2003217244
- Cited by
- 588
- References
- 1
- FWCI
- 19.28
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Cavener, D. R., & Ray, S. C. (1991). Eukaryotic start and stop translation sites. Nucleic Acids Research. https://doi.org/10.1093/nar/19.12.3185
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
