Cited by 611Mitochondrial Function and PathologyAutophagy in Disease and TherapyATP Synthase and ATPases Research

Developmentally Regulated Mitochondrial Fusion Mediated by a Conserved, Novel, Predicted GTPase

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Hales, Karen G, Fuller, Margaret T·1997·Cell

Abstract

The Drosophila melanogaster fuzzy onions (fzo) gene encodes the first known protein mediator of mitochondrial fusion. During Drosophila spermatogenesis, mitochondria in early postmeiotic spermatids aggregate, fuse, and elongate beside the growing flagellar axoneme. fzo mutant males are defective in this developmentally regulated mitochondrial fusion and are sterile. fzo encodes a large, novel, predicted transmembrane GTPase that becomes detectable on spermatid mitochondria late in meiosis II, just prior to fusion, and disappears soon after fusion is complete. Missense mutations that alter conserved residues required for GTP binding in other GTPases inhibit the fusogenic activity of Fzo in vivo but do not affect its localization. Fzo has homologs of unknown function in mammals, nematodes, and yeast.

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Crossref · 10.1016/s0092-8674(00)80319-0

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Authors
Hales, K. G., & Fuller, M. T.
Affiliations
Stanford Medicine (US)
Corresponding author
Fuller, Margaret T
Venue
Cell
Publisher
Elsevier BV
Published
1997-07
Volume
90
Issue
1
Pages
121-129
ISSN
0092-8674 (ISSN-L)
OpenAlex
W2147207574
Cited by
611
References
52
Citations by year
2026: 8 · 2025: 14 · 2024: 21 · 2023: 20 · 2022: 17 · 2021: 22 · 2020: 21 · 2019: 16 · 2018: 24 · 2017: 20 · 2016: 24 · 2015: 19 · 2014: 17 · 2013: 17 · 2012: 39
FWCI
5.10
Type
journal article
Language
en
Open access
Locations
  • Cell (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01hd029194-05)
  • National Human Genome Research Institute (HG00044)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (1RO1-HD29194)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › ATP Synthase and ATPases Research
Keywords
mitochondrial fusion, GTPase, spermatogenesis, meiosis II, male sterility, GTP binding, Drosophila melanogaster, mitochondrial elongation
MeSH terms
Amino Acid Sequence, Animals, Chromosome Mapping, Drosophila melanogaster, Female, Genes, Recessive, Humans, Infertility, Male, Intracellular Membranes, Male, Membrane Fusion, Membrane Proteins, Mitochondria, Molecular Sequence Data, Polymorphism, Genetic, Recombination, Genetic, Spermatids, Mutagenesis, Sequence Alignment, Conserved Sequence, Genes, Insect, Sequence Homology, Amino Acid, GTP Phosphohydrolases, Drosophila Proteins, Animals, Genetically Modified

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