The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Identification of the catalytic and DNA-binding region of the human immunodeficiency virus type I integrase protein
Open accessAbstract
The integrase (IN) protein of the human immunodeficiency virus (HIV) is required for specific cleavage of the viral DNA termini, and subsequent integration of the viral DNA into target DNA. To identify the various domains of the IN protein we generated a series of IN deletion mutants as fusions to maltose-binding protein (MBP). The deletion mutants were tested for their ability to bind DNA, to mediate site-specific cleavage of the viral DNA ends, and to carry out integration and disintegration reactions. We found that the DNA-binding region resides between amino acids 200 and 270 of the 288-residues HIV-1 IN protein. The catalytic domain of the protein was mapped between amino acids 50 and 194. For the specific activities of IN, cleavage of the viral DNA and integration, both the DNA-binding domain and the conserved amino-terminal region of IN are required. These regions are dispensable however, for disintegration activity.
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Cites
HIV-1 DNA integration: Mechanism of viral DNA cleavage and DNA strand transfer
Engelman, A., Mizuuchi, K., & Craigie, R. (1991) · Cell · doi:10.1016/0092-8674(91)90297-c · Cited by 655
Engelman, A., & Craigie, R. (1992) · Journal of Virology · doi:10.1128/jvi.66.11.6361-6369.1992 · Cited by 519
Johnson, M. S., McClure, M. A., Feng, D. F., Gray, J., & Doolittle, R. F. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.20.7648 · Cited by 480
Cited by
Dyda, F., Hickman, A. B., Jenkins, T. M., Engelman, A., Craigie, R., & Davies, D. R. (1994) · Science · doi:10.1126/science.7801124 · Cited by 810
Multiple effects of mutations in human immunodeficiency virus type 1 integrase on viral replication
Engelman, A., Englund, G., Orenstein, J. M., Martin, M. A., & Craigie, R. (1995) · Journal of Virology · doi:10.1128/jvi.69.5.2729-2736.1995 · Cited by 445
Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75
Cherepanov, P., Ambrosio, A. L. B., Rahman, S., Ellenberger, T., & Engelman, A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506924102 · Cited by 408
Solution structure of the N-terminal zinc binding domain of HIV-1 integrase
Cai, M., Zheng, R., Caffrey, M., Craigie, R., Clore, G. M., & Gronenborn, A. M. (1997) · Nature Structural Biology · doi:10.1038/nsb0797-567 · Cited by 342
Doak, T. G., Doerder, F. P., Jahn, C. L., & Herrick, G. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.3.942 · Cited by 323
Metadata
- Authors
- Vink, C., Groeneger, A. A. M. O., & Plasterk, R. H. A.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 1993
- Volume
- 21
- Issue
- 6
- Pages
- 1419-1425
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2171044922
- Cited by
- 264
- References
- 3
- FWCI
- 7.33
- Type
- journal article
- Language
- en
- Open access
- green
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- Vink, C., Groeneger, A. A. M. O., & Plasterk, R. H. A. (1993). Identification of the catalytic and DNA-binding region of the human immunodeficiency virus type I integrase protein. Nucleic Acids Research. https://doi.org/10.1093/nar/21.6.1419
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