The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
A proposed superfamily of transposase genes: transposon-like elements in ciliated protozoa and a common "D35E" motif.
Open accessAbstract
The transposon-like elements TBE1, Tec1, and Tec2 of hypotrichous ciliated protozoa appear to encode a protein that belongs to the IS630-Tc1 family of transposases. The Anabaena IS895 transposase also is placed in this family. We note that most family members transpose into the dinucleotide target, TA, and that members with eukaryotic hosts have a tendency for somatic excision that is carried to an extreme by the ciliate elements. Alignments including the additional members, and also mariner elements, show that transposases of this family share strongly conserved residues in a large C-terminal portion, including a fully conserved dipeptide, Asp-Glu (DE), and a block consisting of a fully conserved Asp and highly conserved Glu, separated by 34 or 35 residues (D35E). This D35E motif likely is homologous to the previously characterized D35E motif of the family of retroviral-retrotransposon integrases and IS3-like transposases. Because it is known that the IS3-retroposon D35E region is a critical portion of a domain capable of various in vitro transposition-related reactions, the results suggest that the two families share homologous catalytic transposase domains and that members of both families may share a common transposition mechanism.
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Repetitive sequences in complex genomes: Structure and evolution
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Metadata
- Authors
- Doak, T. G., Doerder, F. P., Jahn, C. L., & Herrick, G.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1994-02
- Volume
- 91
- Issue
- 3
- Pages
- 942-946
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2077214743
- Cited by
- 323
- References
- 22
- FWCI
- 42.72
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: A proposed superfamily of transposase genes: transposon-like elements in ciliated protozoa and a common "D35E" motif. https://app.cochat.ai/papers/10.1073/pnas.91.3.942
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- Doak, T. G., Doerder, F. P., Jahn, C. L., & Herrick, G. (1994). A proposed superfamily of transposase genes: transposon-like elements in ciliated protozoa and a common "D35E" motif. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.91.3.942
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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