The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Tetracycline-controlled transcription in eukaryotes: novel transactivators with graded transactivation potential
Open accessAbstract
Several tetracycline-controlled transactivators (tTA) were generated which differ in their activation potential by >3 orders of magnitude. The transactivators are fusions between the Tet repressor and minimal transcriptional activation domains derived from Herpes simplex virus protein 16 (VP16). By reducing the VP16 moiety of the previously described tTA to 12 amino acids, potential targets for interactions with various cellular transcription factors were eliminated, as were potential epitopes which may elicit a cellular immune response. When compared with the originally described tTA, these new transactivators are tolerated at higher intracellular concentrations. This will facilitate establishment of tet regulatory systems under a variety of conditions, but particularly when cell type-restricted tetracycline-controlled gene expression is to be achieved in transgenic organisms via homologous recombination.
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Cites
Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.
Gossen, M., & Bujard, H. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.12.5547 · Cited by 4,943
Transcriptional Activation by Tetracyclines in Mammalian Cells
Gossen, M., Freundlieb, S., Bender, G., Müller, G., Hillen, W., & Bujard, H. (1995) · Science · doi:10.1126/science.7792603 · Cited by 2,488
Self-citationA novel mediator between activator proteins and the RNA polymerase II transcription apparatus
Kelleher, R. J., Flanagan, P. M., & Kornberg, R. D. (1990) · Cell · doi:10.1016/0092-8674(90)90685-8 · Cited by 450
Berger, S. L., Piña, B., Silverman, N., Marcus, G. A., Agapite, J., Regier, J. L., Triezenberg, S. J., & Guarente, L. (1992) · Cell · doi:10.1016/0092-8674(92)90100-q · Cited by 435
Cited by
Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells
Masui, S., Nakatake, Y., Toyooka, Y., Shimosato, D., Yagi, R., Takahashi, K., Okochi, H., Okuda, A., Matoba, R., Sharov, A. A., et al. (2007) · Nature Cell Biology · doi:10.1038/ncb1589 · Cited by 1,252
Synthetic biology: new engineering rules for an emerging discipline
Andrianantoandro, E., Basu, S., Karig, D. K., & Weiss, R. (2006) · Molecular Systems Biology · doi:10.1038/msb4100073 · Cited by 1,081
Urlinger, S., Baron, U., Thellmann, M., Hasan, M. T., Bujard, H., & Hillen, W. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.130192197 · Cited by 928
Self-citationAsakawa, K., Suster, M. L., Mizusawa, K., Nagayoshi, S., Kotani, T., Urasaki, A., Kishimoto, Y., Hibi, M., & Kawakami, K. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704963105 · Cited by 560
Tet-On Systems For Doxycycline-inducible Gene Expression
T. Das, A., Tenenbaum, L., & Berkhout, B. (2016) · Current Gene Therapy · doi:10.2174/1566523216666160524144041 · Cited by 434
“This AD minimization removed potential targets for interactions with cellular transcription factors, which reduced toxic squelching effects [16].”
Background
Metadata
- Authors
- Baron, U.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 1997-07-15
- Volume
- 25
- Issue
- 14
- Pages
- 2723-2729
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2058527659
- Cited by
- 335
- References
- 4
- FWCI
- 7.12
- Type
- journal article
- Language
- en
- Open access
- green
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- Baron, U. (1997). Tetracycline-controlled transcription in eukaryotes: novel transactivators with graded transactivation potential. Nucleic Acids Research. https://doi.org/10.1093/nar/25.14.2723
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