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RefSeq and LocusLink: NCBI gene-centered resources

Open access
Pruitt, K. D.·2001·Nucleic Acids Research

Abstract

Thousands of genes have been painstakingly identified and characterized a few genes at a time. Many thousands more are being predicted by large scale cDNA and genomic sequencing projects, with levels of evidence ranging from supporting mRNA sequence and comparative genomics to computing ab initio models. This, coupled with the burgeoning scientific literature, makes it critical to have a comprehensive directory for genes and reference sequences for key genomes. The NCBI provides two resources, LocusLink and RefSeq, to meet these needs. LocusLink organizes information around genes to generate a central hub for accessing gene-specific information for fruit fly, human, mouse, rat and zebrafish. RefSeq provides reference sequence standards for genomes, transcripts and proteins; human, mouse and rat mRNA RefSeqs, and their corresponding proteins, are discussed here. Together, RefSeq and LocusLink provide a non-redundant view of genes and other loci to support research on genes and gene families, variation, gene expression and genome annotation. Additional information about LocusLink and RefSeq is available at http://www.ncbi.nlm.nih.gov/LocusLink/.

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    Altschul, S. F., Gish, W., Miller, W., Myers, E. W., & Lipman, D. J. (1990) · Journal of Molecular Biology · doi:10.1006/jmbi.1990.9999 · Cited by 98,669

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Metadata

Authors
Pruitt, K. D.
Venue
Nucleic Acids Research
Published
2001-01-01
Volume
29
Issue
1
Pages
137-140
ISSN
  • 0305-1048 (ISSN-L)
  • 1362-4962
OpenAlex
W2165270659
Cited by
893
References
1
FWCI
48.64
Type
journal article
Language
en
Open access
green

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Pruitt, K. D. (2001). RefSeq and LocusLink: NCBI gene-centered resources. Nucleic Acids Research. https://doi.org/10.1093/nar/29.1.137

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