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DNA double-strand breaks and alkali-labile bonds produced by bleomycin
Open accessAbstract
Both in linear T2 DNA, analyyzed by velocity sedimentation, and in supercoiled Col EL DNA, analyzed by gel electrophoresis, the number of double-strand breaks produced by bleomycin was directly propotional to the number of single-strand breaks and was far greater than the number expected from random coincidence of single-strand breaks, suggesting that the bleomycin-induced double-strand breaks occur as an independent event. In Col EL DNA, at least twice as many single-strand breaks were found under alkaline assay conditions as were found under neutral conditions, showing the production of alkaline-labile bonds by bleomycin.
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Citations
Cited by
Bleomycins: towards better therapeutics
Chen, J., & Stubbe, J. (2005) · Nature Reviews Cancer · doi:10.1038/nrc1547 · Cited by 664
Povirk, L. F. (1996) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/0027-5107(96)00023-1 · Cited by 431
Self-citationBleomycin‐induced strand‐scission of DNA. Mechanism of deoxyribose cleavage
Giloni, L., Takeshita, M., Johnson, F., Iden, C., & Grollman, A. P. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)68888-5 · Cited by 412
Chromatin and nucleosome dynamics in DNA damage and repair
Hauer, M. H., & Gasser, S. M. (2017) · Genes & Development · doi:10.1101/gad.307702.117 · Cited by 328
Highly efficient gene targeting in the Aspergillus niger kusA mutant
Meyer, V., Arentshorst, M., El-Ghezal, A., Drews, A.-C., Kooistra, R., van den Hondel, C. A. M. J. J., & Ram, A. F. J. (2007) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2006.12.021 · Cited by 307
Metadata
- Authors
- Povirk, L. F., Wübker, W., Köhnlein, W., & Hutchinson, F.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 1977
- Volume
- 4
- Issue
- 10
- Pages
- 3573-3580
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2071638708
- Cited by
- 291
- References
- 0
- FWCI
- 4.06
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Povirk, L. F., Wübker, W., Köhnlein, W., & Hutchinson, F. (1977). DNA double-strand breaks and alkali-labile bonds produced by bleomycin. Nucleic Acids Research. https://doi.org/10.1093/nar/4.10.3573
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