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MspI, an isoschizomer of HpaII which cleaves both unmethylated and methylated HpaII sites
Open accessAbstract
The cleavage of DNA by restriction endonucleases HpaII and HapII is prevented by the presence of a 5-methyl group at the internal C residue of its recognition sequence CCGG. MspI, an isoschizomer of HpaII available from New England Biolabs, cleaves DNA irrespective of the presence of a methyl group at this position. This enzyme cleaves DNA from Haemophilus parainfluenzae and Haemophilus aphrophilus readily while HpaII and HapII cannot degrade these DNAs. Practically all HpaII sites in mammalian sperm DNA are also protected by methylation at the internal C position since HpaII and HapII barely cleave this DNA (average molecular weight 40 kb). MspI, however, cleaves the DNA to an average size of about 5 kb.
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Citations
Cited by
DNA Methylation and Gene Function
Razin, A., & Riggs, A. D. (1980) · Science · doi:10.1126/science.6254144 · Cited by 2,071
DNA methylation and the frequency of CpG in animal DNA
Bird, A. P. (1980) · Nucleic Acids Research · doi:10.1093/nar/8.7.1499 · Cited by 1,175
DNA methylation and gene expression
Razin, A., & Cedar, H. (1991) · Microbiological Reviews · doi:10.1128/mmbr.55.3.451-458.1991 · Cited by 771
DNA methylation controls the inducibility of the mouse metallothionein-I gene in lymphoid cells
Compere, S. J., & Palmiter, R. D. (1981) · Cell · doi:10.1016/0092-8674(81)90248-8 · Cited by 465
5-Methylcytosine, Gene Regulation, and Cancer
(1983) · Advances in Cancer Research · doi:10.1016/s0065-230x(08)60678-8 · Cited by 422
Metadata
- Authors
- Waalwijk, C., & Flavell, R. A.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 1978
- Volume
- 5
- Issue
- 9
- Pages
- 3231-3236
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2020844796
- Cited by
- 399
- References
- 0
- FWCI
- 13.26
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: MspI, an isoschizomer of HpaII which cleaves both unmethylated and methylated HpaII sites. https://app.cochat.ai/papers/10.1093/nar/5.9.3231
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- Waalwijk, C., & Flavell, R. A. (1978). MspI, an isoschizomer of HpaII which cleaves both unmethylated and methylated HpaII sites. Nucleic Acids Research. https://doi.org/10.1093/nar/5.9.3231
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
