The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Rfam 14: expanded coverage of metagenomic, viral and microRNA families
Open accessAbstract
Rfam is a database of RNA families where each of the 3444 families is represented by a multiple sequence alignment of known RNA sequences and a covariance model that can be used to search for additional members of the family. Recent developments have involved expert collaborations to improve the quality and coverage of Rfam data, focusing on microRNAs, viral and bacterial RNAs. We have completed the first phase of synchronising microRNA families in Rfam and miRBase, creating 356 new Rfam families and updating 40. We established a procedure for comprehensive annotation of viral RNA families starting with Flavivirus and Coronaviridae RNAs. We have also increased the coverage of bacterial and metagenome-based RNA families from the ZWD database. These developments have enabled a significant growth of the database, with the addition of 759 new families in Rfam 14. To facilitate further community contribution to Rfam, expert users are now able to build and submit new families using the newly developed Rfam Cloud family curation system. New Rfam website features include a new sequence similarity search powered by RNAcentral, as well as search and visualisation of families with pseudoknots. Rfam is freely available at https://rfam.org.
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Basic local alignment search tool
Altschul, S. F., Gish, W., Miller, W., Myers, E. W., & Lipman, D. J. (1990) · Journal of Molecular Biology · doi:10.1006/jmbi.1990.9999 · Cited by 98,669
O'Leary, N. A., Wright, M. W., Brister, J. R., Ciufo, S., Haddad, D., McVeigh, R., Rajput, B., Robbertse, B., Smith-White, B., Ako-Adjei, D., et al. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkv1189 · Cited by 6,357
miRBase: from microRNA sequences to function
Kozomara, A., Birgaoanu, M., & Griffiths-Jones, S. (2019) · Nucleic Acids Research · doi:10.1093/nar/gky1141 · Cited by 4,843
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Accurate prediction of protein–nucleic acid complexes using RoseTTAFoldNA
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Rubin, B. E., Diamond, S., Cress, B. F., Crits-Christoph, A., Lou, Y. C., Borges, A. L., Shivram, H., He, C., Xu, M., Zhou, Z., et al. (2021) · Nature Microbiology · doi:10.1038/s41564-021-01014-7 · Cited by 322
Metadata
- Authors
- Kalvari, I., Nawrocki, E. P., Ontiveros-Palacios, N., Argasinska, J., Lamkiewicz, K., Marz, M., Griffiths-Jones, S., Toffano-Nioche, C., Gautheret, D., Weinberg, Z., Rivas, E., Eddy, S. R., Finn, R. D., Bateman, A., & Petrov, A. I.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2020-11-19
- Volume
- 49
- Issue
- D1
- Pages
- D192-D200
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W3100348855
- Cited by
- 1,045
- References
- 3
- FWCI
- 29.87
- Type
- journal article
- Language
- en
- Open access
- gold
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- Kalvari, I., Nawrocki, E. P., Ontiveros-Palacios, N., Argasinska, J., Lamkiewicz, K., Marz, M., Griffiths-Jones, S., Toffano-Nioche, C., Gautheret, D., Weinberg, Z., Rivas, E., Eddy, S. R., Finn, R. D., Bateman, A., & Petrov, A. I. (2021). Rfam 14: expanded coverage of metagenomic, viral and microRNA families. Nucleic Acids Research. https://doi.org/10.1093/nar/gkaa1047
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