scTraitReg: a single-cell multi-omic database of trait-relevant transcription factor eRegulons
Open accessAbstract
Genome-wide association studies (GWAS) identify loci associated with human diseases and disease-related traits, but the regulators and cellular contexts linked to these signals remain difficult to resolve. We present scTraitReg, a database of trait-relevant transcription factor (TF) eRegulons—TFs with their target genes and linked cis-regulatory regions—at single-cell resolution. scTraitReg integrates 655 sets of curated GWAS summary statistics covering 122 Medical Subject Headings (MeSH) disease terms with 111 human single-cell multi-omic datasets profiling RNA and chromatin accessibility in the same cells. The resource spans 34 tissues, 252 cell types, 2 081 538 cells, and 2208 curated GWAS—single-cell analysis pairs. Across these analyses, it contains 2 840 939 TF–cell-type records for 886 regulators; 67 666 records met all three criteria—cell-type specificity, genetic relevance, and the trait-associated regulon score—and were included as candidate trait-relevant eRegulon records. Each record links to the TF—target regulatory network with its cis-regulatory regions, cell-type-resolved evidence, per-cell regulon module scores, and target-gene enrichment, all available as downloadable tables. Users can search by disease, tissue, cell type, or regulator and examine these associations through interactive visualizations. scTraitReg thus provides a searchable and reusable resource linking genetic associations to cell-type-specific regulatory programs, and is freely available at https://www.sctraitreg.bio/.
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Flagged first, then by citations
- Authors
- Chen, H., Liu, Y., Rui, X., Li, S., Sun, L., Xiao, G., Tang, H., Sun, Y., Guan, X., & Cao, C.
- Affiliations
- Nanjing Medical University (CN)
- Nanjing University of Chinese Medicine (CN)
- Second Affiliated Hospital of Nanjing Medical University (CN)
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2026-10-22
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W7223182884
- Semantic Scholar
- 526837233e3417c587a079ba785e3ea0e9ba5249
- Cited by
- 0
- References
- 53
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nucleic Acids Research (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (62471240, 62231013)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Single-cell and spatial transcriptomics
- Keywords
- single-cell multi-omics, GWAS summary statistics, cis-regulatory elements, chromatin accessibility, cell type-specific gene regulation, disease characteristics, regulatory networks, single-cell RNA sequencing
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