The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Evolution of transcription factors and the gene regulatory network in Escherichia coli
Open accessAbstract
The most detailed information presently available for an organism's transcriptional regulation network is that for the prokaryote Escherichia coli. In order to gain insight into the evolution of the E.coli regulatory network, we analysed information obtainable for the domains and protein families of the transcription factors and regulated genes. About three-quarters of the 271 transcription factors we identified are two-domain proteins, consisting of a DNA-binding domain along with a regulatory domain. The regulatory domains mainly bind small molecules. Many groups of transcription factors have identical domain architectures, and this implies that roughly three-quarters of the transcription factors have arisen as a consequence of gene duplication. In contrast, there is little evidence of duplication of regulatory regions together with regulated genes or of transcription factors together with regulated genes. Thirty-eight, out of the 121 transcription factors for which one or more regulated genes are known, regulate other transcription factors. This amplification effect, as well as large differences between the numbers of genes directly regulated by transcription factors, means that there are about 10 global regulators which each control many more genes than the other transcription factors.
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Cites
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Cited by
Dang, C. V., O’Donnell, K. A., Zeller, K. I., Nguyen, T., Osthus, R. C., & Li, F. (2006) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2006.07.014 · Cited by 1,188
The regulation of bacterial transcription initiation
Browning, D. F., & Busby, S. J. W. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro787 · Cited by 1,019
Evolution of Two-Component Signal Transduction Systems
Capra, E. J., & Laub, M. T. (2012) · Annual Review of Microbiology · doi:10.1146/annurev-micro-092611-150039 · Cited by 705
The Coherent Feedforward Loop Serves as a Sign-sensitive Delay Element in Transcription Networks
Mangan, S., Zaslaver, A., & Alon, U. (2003) · Journal of Molecular Biology · doi:10.1016/j.jmb.2003.09.049 · Cited by 553
Identifying global regulators in transcriptional regulatory networks in bacteria
Martı́nez-Antonio, A., & Collado-Vides, J. (2003) · Current Opinion in Microbiology · doi:10.1016/j.mib.2003.09.002 · Cited by 526
Metadata
- Authors
- Madan Babu, M.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-02-15
- Volume
- 31
- Issue
- 4
- Pages
- 1234-1244
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2165392091
- Cited by
- 353
- References
- 35
- FWCI
- 12.89
- Type
- journal article
- Language
- en
- Open access
- bronze
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