The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Human mitochondrial DNA is packaged with TFAM
Open accessAbstract
Mitochondrial transcription factor A (TFAM), a member of the high mobility group proteins, is essential for maintenance of mitochondrial DNA (mtDNA). Most TFAM and mtDNA (both of which are normally soluble) was recovered from the particulate fraction of human placental mitochondria when extracted with the non-ionic detergent Nonidet P-40. mtDNA and TFAM were co-immunoprecipitated by anti-TFAM antibodies. TFAM was released into the supernatant by DNase I digestion of mtDNA in the particulate fraction. Thus, TFAM and mtDNA are tightly associated with each other, and it is likely that few TFAM or mtDNA molecules exist in an unbound form in mitochondria. Based on the fact that TFAM is abundant enough to wrap mtDNA entirely, these results suggest that human mtDNA is packaged with TFAM.
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Mitochondrial transcription factor A is necessary for mtDNA maintance and embryogenesis in mice
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MITOCHONDRIAL DNA MAINTENANCE IN VERTEBRATES
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Replication and Transcription of Vertebrate Mitochondrial DNA
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Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA
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“LSP, a promoter for transcription of the light strand (25), would be bound ®rst and left last by TFAM, because TFAM has higher af®nity to LSP than to the rest of the mtDNA molecule (2,20,26) and fully activates the LSP-speci®c transcription at a level where a ratio of TFAM/DNA template is ~10 in the presence of mitoch…”
BackgroundOrganization of multiple nucleoids and DNA molecules in mitochondria of a human cell
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A close relative of the nuclear, chromosomal high-mobility group protein HMG1 in yeast mitochondria.
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Cited by
Mitochondrial transcription factor A regulates mtDNA copy number in mammals
Ekstrand, M. I. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh109 · Cited by 919
ER-mitochondria contacts couple mtDNA synthesis with mitochondrial division in human cells
Lewis, S. C., Uchiyama, L. F., & Nunnari, J. (2016) · Science · doi:10.1126/science.aaf5549 · Cited by 673
Campbell, C. T., Kolesar, J. E., & Kaufman, B. A. (2012) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2012.03.002 · Cited by 462
The Maintenance of Mitochondrial DNA Integrity--Critical Analysis and Update
Alexeyev, M., Shokolenko, I., Wilson, G., & LeDoux, S. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a012641 · Cited by 458
Mitochondrial oxidative stress and dysfunction in myocardial remodelling
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Metadata
- Authors
- Alam, T. I.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-03-15
- Volume
- 31
- Issue
- 6
- Pages
- 1640-1645
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W1988888878
- Cited by
- 393
- References
- 33
- FWCI
- 6.22
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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