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PrediSi: prediction of signal peptides and their cleavage positions
Open accessAbstract
We have developed PrediSi (Prediction of Signal peptides), a new tool for predicting signal peptide sequences and their cleavage positions in bacterial and eukaryotic amino acid sequences. In contrast to previous prediction tools, our new software is especially useful for the analysis of large datasets in real time with high accuracy. PrediSi allows the evaluation of whole proteome datasets, which are currently accumulating as a result of numerous genome projects and proteomics experiments. The method employed is based on a position weight matrix approach improved by a frequency correction which takes in to consideration the amino acid bias present in proteins. The software was trained using sequences extracted from the most recent version of the SwissProt database. PrediSi is accessible via a web interface. An extra Java package was designed for the integration of PrediSi into other software projects. The tool is freely available on the World Wide Web at http://www.predisi.de.
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Cited by
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Petersen, T. N., Brunak, S., von Heijne, G., & Nielsen, H. (2011) · Nature Methods · doi:10.1038/nmeth.1701 · Cited by 8,847
Evolution of Escherichia coli Expression System in Producing Antibody Recombinant Fragments
Sandomenico, A., Sivaccumar, J. P., & Ruvo, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176324 · Cited by 134
Optimisation of signal peptide for recombinant protein secretion in bacterial hosts
Low, K. O., Muhammad Mahadi, N., & Md. Illias, R. (2013) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-013-4831-z · Cited by 130
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Organization of lamprey variable lymphocyte receptor C locus and repertoire development
Das, S., Hirano, M., Aghaallaei, N., Bajoghli, B., Boehm, T., & Cooper, M. D. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1302500110 · Cited by 57
Metadata
- Authors
- Hiller, K., Grote, A., Scheer, M., Munch, R., & Jahn, D.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-07-01
- Volume
- 32
- Issue
- Web Server
- Pages
- W375-W379
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2149649966
- Cited by
- 495
- References
- 0
- FWCI
- 4.81
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Hiller, K., Grote, A., Scheer, M., Munch, R., & Jahn, D. (2004). PrediSi: prediction of signal peptides and their cleavage positions. Nucleic Acids Research. https://doi.org/10.1093/nar/gkh378
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