The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
The effect of chemical modifications on the thermal stability of different G-quadruplex-forming oligonucleotides
Open accessAbstract
A systematic study of the thermal and conformational properties of chemically modified G-quadruplexes of different molecularities is reported. The effect of backbone charge and atom size, thymine/uracyl substitution as well as the effect of modification at the ribose 2'-position was analyzed by UV spectroscopy. Additional calorimetric studies were performed on different modified forms of the human telomeric sequence. Determination of the differential spectra allowed more insights into the conformational properties of the oligonucleotides. Lack of negative charge at the phosphate backbone yielded to a general destabilization of the G-quadruplex structure. On the other hand, substitution of thymine with uracyl resulted in a moderate or strong stabilization of the structure. Additional modification at the sugar 2'-position gave rise to different effects depending on the molecularity of the quadruplex. In particular, loss of hydrogen bond capacity at the 2'-position strongly affected the conformation of the G-quadruplex. Altogether, these results demonstrate that the effect of some modifications depends on the sequence context, thus providing helpful information for the use of chemically modified quadruplexes as therapeutic agents or as structural elements of supramolecular complexes.
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An RNA G-quadruplex in the 5′ UTR of the NRAS proto-oncogene modulates translation
Kumari, S., Bugaut, A., Huppert, J. L., & Balasubramanian, S. (2007) · Nature Chemical Biology · doi:10.1038/nchembio864 · Cited by 822
Metal Cations in G-Quadruplex Folding and Stability
Bhattacharyya, D., Mirihana Arachchilage, G., & Basu, S. (2016) · Frontiers in Chemistry · doi:10.3389/fchem.2016.00038 · Cited by 621
Heterochromatin protein 1α interacts with parallel RNA and DNA G-quadruplexes
Roach, R. J., Garavís, M., González, C., Jameson, G. B., Filichev, V. V., & Hale, T. K. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkz1138 · Cited by 518
Thermal difference spectra: a specific signature for nucleic acid structures
Mergny, J.-L. (2005) · Nucleic Acids Research · doi:10.1093/nar/gni134 · Cited by 469
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Metadata
- Authors
- Sacca, B.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-02-23
- Volume
- 33
- Issue
- 4
- Pages
- 1182-1192
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W1974568730
- Cited by
- 259
- References
- 51
- FWCI
- 3.92
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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