The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Thermal difference spectra: a specific signature for nucleic acid structures
Open accessAbstract
We show that nucleic acid structures may be conveniently and inexpensively characterized by their UV thermal difference spectra. A thermal difference spectrum (TDS) is obtained for a nucleic acid by simply recording the ultraviolet absorbance spectra of the unfolded and folded states at temperatures above and below its melting temperature (T(m)). The difference between these two spectra is the TDS. The TDS has a specific shape that is unique for each type of nucleic acid structure, a conclusion that is based on a comparison of >900 spectra from 200 different sequences. The shape of the TDS reflects the subtleties of base stacking interactions that occur uniquely within each type of nucleic acid structure. TDS provides a simple, inexpensive and rapid method to obtain structural insight into nucleic acid structures, which is applicable to both DNA and RNA from short oligomers to polynucleotides. TDS complements circular dichroism as a tool for the structural characterization of nucleic acids in solution.
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Cites
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Cited by
Re-evaluation of G-quadruplex propensity with G4Hunter
Bedrat, A., Lacroix, L., & Mergny, J.-L. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw006 · Cited by 687
Self-citationTopological Characterization of Nucleic Acid G‐Quadruplexes by UV Absorption and Circular Dichroism
Karsisiotis, A. I., Hessari, N. M., Novellino, E., Spada, G. P., Randazzo, A., & Webba da Silva, M. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201105193 · Cited by 414
Rudimentary G-quadruplex-based telomere capping in Saccharomyces cerevisiae
Smith, J. S., Chen, Q., Yatsunyk, L. A., Nicoludis, J. M., Garcia, M. S., Kranaster, R., Balasubramanian, S., Monchaud, D., Teulade-Fichou, M.-P., Abramowitz, L., et al. (2011) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2033 · Cited by 135
Prediction of DNA i-motifs via machine learning
Yang, B., Guneri, D., Yu, H., Wright, E. P., Chen, W., Waller, Z. A. E., & Ding, Y. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae092 · Cited by 29
Metadata
- Authors
- Mergny, J.-L.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-09-07
- Volume
- 33
- Issue
- 16
- Pages
- e138-e138
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2027738669
- Cited by
- 469
- References
- 25
- FWCI
- 3.57
- Type
- journal article
- Language
- en
- Open access
- gold
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