The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
Alu elements as regulators of gene expression
Open accessAbstract
Alu elements are the most abundant repetitive elements in the human genome; they emerged 65 million years ago from a 5' to 3' fusion of the 7SL RNA gene and amplified throughout the human genome by retrotransposition to reach the present number of more than one million copies. Over the last years, several lines of evidence demonstrated that these elements modulate gene expression at the post-transcriptional level in at least three independent manners. They have been shown to be involved in alternative splicing, RNA editing and translation regulation. These findings highlight how the genome adapted to these repetitive elements by assigning them important functions in regulation of gene expression. Alu elements should therefore be considered as a large reservoir of potential regulatory functions that have been actively participating in primate evolution.
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Cites
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Mechanisms of Alternative Pre-Messenger RNA Splicing
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Selfish DNA: the ultimate parasite
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Alu repeats and human genomic diversity
Batzer, M. A., & Deininger, P. L. (2002) · Nature Reviews Genetics · doi:10.1038/nrg798 · Cited by 1,470
A genomic view of alternative splicing
Modrek, B., & Lee, C. (2002) · Nature Genetics · doi:10.1038/ng0102-13 · Cited by 1,302
Drosophila Dscam Is an Axon Guidance Receptor Exhibiting Extraordinary Molecular Diversity
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Cited by
Evolutionary dynamics of transposable elements in the short-tailed opossum Monodelphis domestica
Gentles, A. J., Wakefield, M. J., Kohany, O., Gu, W., Batzer, M. A., Pollock, D. D., & Jurka, J. (2007) · Genome Research · doi:10.1101/gr.6070707 · Cited by 156
Pelikan, R. C., Kelly, J. A., Fu, Y., Lareau, C. A., Tessneer, K. L., Wiley, G. B., Wiley, M. M., Glenn, S. B., Harley, J. B., Guthridge, J. M., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05328-9 · Cited by 94
Metadata
- Authors
- Häsler, J., & Strub, K.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-10-04
- Volume
- 34
- Issue
- 19
- Pages
- 5491-5497
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2140272554
- Cited by
- 299
- References
- 63
- FWCI
- 25.17
- Type
- journal article
- Language
- en
- Open access
- gold
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