The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Different loop arrangements of intramolecular human telomeric (3+1) G-quadruplexes in K+ solution
Open accessAbstract
Intramolecular G-quadruplexes formed by the human telomeric G-rich strand are promising anticancer targets. Here we show that four-repeat human telomeric DNA sequences can adopt two different intramolecular G-quadruplex folds in K+ solution. The two structures contain the (3+1) G-tetrad core, in which three G-tracts are oriented in one direction and the fourth in the opposite direction, with one double-chain-reversal and two edgewise loops, but involve different loop arrangements. This result indicates the robustness of the (3+1) core G-quadruplex topology, thereby suggesting it as an important platform for structure-based drug design. Our data also support the view that multiple human telomeric G-quadruplex conformations coexist in K+ solution. Furthermore, even small changes to flanking sequences can perturb the equilibrium between different coexisting G-quadruplex forms.
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Cites
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BackgroundCrystal structure of parallel quadruplexes from human telomeric DNA
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Self-citationDNA and its associated processes as targets for cancer therapy
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Cited by
Four-stranded nucleic acids: structure, function and targeting of G-quadruplexes
Huppert, J. L. (2008) · Chemical Society Reviews · doi:10.1039/b702491f · Cited by 494
Polymorphism of human telomeric quadruplex structures
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Structure of Human Telomeric DNA in Crowded Solution
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Metadata
- Authors
- Phan, A. T., Luu, K. N., & Patel, D. J.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-10-12
- Volume
- 34
- Issue
- 19
- Pages
- 5715-5719
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2166965022
- Cited by
- 320
- References
- 35
- FWCI
- 7.98
- Type
- journal article
- Language
- en
- Open access
- gold
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- Phan, A. T., Luu, K. N., & Patel, D. J. (2006). Different loop arrangements of intramolecular human telomeric (3+1) G-quadruplexes in K+ solution. Nucleic Acids Research. https://doi.org/10.1093/nar/gkl726
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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