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STRING 7--recent developments in the integration and prediction of protein interactions

Open access
von Mering, C., Jensen, L. J., Kuhn, M., Chaffron, S., Doerks, T., Kruger, B., Snel, B., Bork, P.·2007·Nucleic Acids Research

Abstract

Information on protein-protein interactions is still mostly limited to a small number of model organisms, and originates from a wide variety of experimental and computational techniques. The database and online resource STRING generalizes access to protein interaction data, by integrating known and predicted interactions from a variety of sources. The underlying infrastructure includes a consistent body of completely sequenced genomes and exhaustive orthology classifications, based on which interaction evidence is transferred between organisms. Although primarily developed for protein interaction analysis, the resource has also been successfully applied to comparative genomics, phylogenetics and network studies, which are all facilitated by programmatic access to the database backend and the availability of compact download files. As of release 7, STRING has almost doubled to 373 distinct organisms, and contains more than 1.5 million proteins for which associations have been pre-computed. Novel features include AJAX-based web-navigation, inclusion of additional resources such as BioGRID, and detailed protein domain annotation. STRING is available at http://string.embl.de/

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Metadata

Authors
von Mering, C., Jensen, L. J., Kuhn, M., Chaffron, S., Doerks, T., Kruger, B., Snel, B., & Bork, P.
Venue
Nucleic Acids Research
Published
2007-01-03
Volume
35
Issue
Database
Pages
D358-D362
ISSN
  • 0305-1048 (ISSN-L)
  • 1362-4962
OpenAlex
W2135805255
Cited by
665
References
3
FWCI
34.75
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: STRING 7--recent developments in the integration and prediction of protein interactions. https://app.cochat.ai/papers/10.1093/nar/gkl825
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von Mering, C., Jensen, L. J., Kuhn, M., Chaffron, S., Doerks, T., Kruger, B., Snel, B., & Bork, P. (2007). STRING 7--recent developments in the integration and prediction of protein interactions. Nucleic Acids Research. https://doi.org/10.1093/nar/gkl825

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