The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
OPTIMIZER: a web server for optimizing the codon usage of DNA sequences
Open accessAbstract
OPTIMIZER is an on-line application that optimizes the codon usage of a gene to increase its expression level. Three methods of optimization are available: the 'one amino acid-one codon' method, a guided random method based on a Monte Carlo algorithm, and a new method designed to maximize the optimization with the fewest changes in the query sequence. One of the main features of OPTIMIZER is that it makes it possible to optimize a DNA sequence using pre-computed codon usage tables from a predicted group of highly expressed genes from more than 150 prokaryotic species under strong translational selection. These groups of highly expressed genes have been predicted using a new iterative algorithm. In addition, users can use, as a reference set, a pre-computed table containing the mean codon usage of ribosomal protein genes and, as a novelty, the tRNA gene-copy numbers. OPTIMIZER is accessible free of charge at http://genomes.urv.es/OPTIMIZER.
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Sharp, P. M., & Li, W.-H. (1987) · Nucleic Acids Research · doi:10.1093/nar/15.3.1281 · Cited by 3,992
Codon bias and heterologous protein expression
Gustafsson, C., Govindarajan, S., & Minshull, J. (2004) · Trends in Biotechnology · doi:10.1016/j.tibtech.2004.04.006 · Cited by 1,330
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Metadata
- Authors
- Puigbo, P., Guzman, E., Romeu, A., & Garcia-Vallve, S.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-05-08
- Volume
- 35
- Issue
- Web Server
- Pages
- W126-W131
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2006607348
- Cited by
- 603
- References
- 2
- FWCI
- 4.43
- Type
- journal article
- Language
- en
- Open access
- gold
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- Puigbo, P., Guzman, E., Romeu, A., & Garcia-Vallve, S. (2007). OPTIMIZER: a web server for optimizing the codon usage of DNA sequences. Nucleic Acids Research. https://doi.org/10.1093/nar/gkm219
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