The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Structure of two intramolecular G-quadruplexes formed by natural human telomere sequences in K + solution †
Open accessAbstract
Intramolecular G-quadruplexes formed by human telomere sequences are attractive anticancer targets. Recently, four-repeat human telomere sequences have been shown to form two different intramolecular (3 + 1) G-quadruplexes in K(+) solution (Form 1 and Form 2). Here we report on the solution structures of both Form 1 and Form 2 adopted by natural human telomere sequences. Both structures contain the (3 + 1) G-tetrad core with one double-chain-reversal and two edgewise loops, but differ in the successive order of loop arrangements within the G-quadruplex scaffold. Our results provide the structural details at the two ends of the G-tetrad core in the context of natural sequences and information on different loop conformations. This structural information might be important for our understanding of telomere G-quadruplex structures and for anticancer drug design targeted to such scaffolds.
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Cites
Specific Association of Human Telomerase Activity with Immortal Cells and Cancer
Kim, N. W., Piatyszek, M. A., Prowse, K. R., Harley, C. B., West, M. D., Ho, P. L. C., Coviello, G. M., Wright, W. E., Weinrich, S. L., & Shay, J. W. (1994) · Science · doi:10.1126/science.7605428 · Cited by 7,091 · cited 1×
“G-quadruplexes formed by human telomere sequences are promising anticancer targets (12–16), because formation of such structures inhibits the activity of telomerase (17–19), an enzyme (20) that is required for the proliferation of 80%–85% of cancer cells (21).”
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Cited by
Structural Basis of DNA Quadruplex Recognition by an Acridine Drug
Campbell, N. H., Parkinson, G. N., Reszka, A. P., & Neidle, S. (2008) · Journal of the American Chemical Society · doi:10.1021/ja8016973 · Cited by 326
Chemistry in human telomere biology: structure, function and targeting of telomere DNA/RNA
Xu, Y. (2011) · Chemical Society Reviews · doi:10.1039/c0cs00134a · Cited by 323
Photocrosslinking of human telomeric G-quadruplex loops by anti cyclobutane thymine dimer formation
Su, D. G. T., Fang, H., Gross, M. L., & Taylor, J.-S. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902386106 · Cited by 55
Metadata
- Authors
- Phan, A. T., Kuryavyi, V., Luu, K. N., & Patel, D. J.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-09-25
- Volume
- 35
- Issue
- 19
- Pages
- 6517-6525
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2166630132
- Cited by
- 520
- References
- 1
- FWCI
- 11.13
- Type
- journal article
- Language
- en
- Open access
- gold
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- Phan, A. T., Kuryavyi, V., Luu, K. N., & Patel, D. J. (2007). Structure of two intramolecular G-quadruplexes formed by natural human telomere sequences in K + solution †. Nucleic Acids Research. https://doi.org/10.1093/nar/gkm706
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
