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CDD: specific functional annotation with the Conserved Domain Database

Open access
Marchler-Bauer, A., Anderson, J. B., Chitsaz, F., Derbyshire, M. K., DeWeese-Scott, C., Fong, J. H., Geer, L. Y., Geer, R. C., Gonzales, N. R., Gwadz, M., He, S., Hurwitz, D. I., Jackson, J. D., Ke, Z., Lanczycki, C. J., Liebert, C. A., Liu, C., Lu, F., Lu, S., Marchler, G. H., Mullokandov, M., Song, J. S., Tasneem, A., Thanki, N., Yamashita, R. A., Zhang, D., Zhang, N., Bryant, S. H.·2009·Nucleic Acids Research

Abstract

NCBI's Conserved Domain Database (CDD) is a collection of multiple sequence alignments and derived database search models, which represent protein domains conserved in molecular evolution. The collection can be accessed at http://www.ncbi.nlm.nih.gov/Structure/cdd/cdd.shtml, and is also part of NCBI's Entrez query and retrieval system, cross-linked to numerous other resources. CDD provides annotation of domain footprints and conserved functional sites on protein sequences. Precalculated domain annotation can be retrieved for protein sequences tracked in NCBI's Entrez system, and CDD's collection of models can be queried with novel protein sequences via the CD-Search service at http://www.ncbi.nlm.nih.gov/Structure/cdd/wrpsb.cgi. Starting with the latest version of CDD, v2.14, information from redundant and homologous domain models is summarized at a superfamily level, and domain annotation on proteins is flagged as either 'specific' (identifying molecular function with high confidence) or as 'non-specific' (identifying superfamily membership only).

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Metadata

Authors
Marchler-Bauer, A., Anderson, J. B., Chitsaz, F., Derbyshire, M. K., DeWeese-Scott, C., Fong, J. H., Geer, L. Y., Geer, R. C., Gonzales, N. R., Gwadz, M., He, S., Hurwitz, D. I., Jackson, J. D., Ke, Z., Lanczycki, C. J., Liebert, C. A., Liu, C., Lu, F., Lu, S., Marchler, G. H., Mullokandov, M., Song, J. S., Tasneem, A., Thanki, N., Yamashita, R. A., Zhang, D., Zhang, N., & Bryant, S. H.
Venue
Nucleic Acids Research
Published
2009-01-01
Volume
37
Issue
Database
Pages
D205-D210
ISSN
  • 0305-1048 (ISSN-L)
  • 1362-4962
OpenAlex
W2035333716
Cited by
1,071
References
2
FWCI
63.65
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: CDD: specific functional annotation with the Conserved Domain Database. https://app.cochat.ai/papers/10.1093/nar/gkn845
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Marchler-Bauer, A., Anderson, J. B., Chitsaz, F., Derbyshire, M. K., DeWeese-Scott, C., Fong, J. H., Geer, L. Y., Geer, R. C., Gonzales, N. R., Gwadz, M., He, S., Hurwitz, D. I., Jackson, J. D., Ke, Z., Lanczycki, C. J., Liebert, C. A., Liu, C., Lu, F., Lu, S., . . . Bryant, S. H. (2009). CDD: specific functional annotation with the Conserved Domain Database. Nucleic Acids Research. https://doi.org/10.1093/nar/gkn845

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