The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Twist-1 regulates the miR-199a/214 cluster during development
Open accessAbstract
MicroRNAs are known to regulate developmental processes but their mechanism of regulation remains largely uncharacterized. We show the transcription factor Twist-1 drives the expression of a 7.9-kb noncoding RNA transcript (from the Dynamin-3 gene intron) that encodes a miR-199a and miR-214 cluster. We also show that knocking down Twist-1 with shRNAs decreased miR-199a/214 levels and that Twist-1 bound an E-Box promoter motif to developmentally regulate the expression of these miRNAs. The expression of HIF-1 (known to mediate Twist-1 transcription), miR-199a and miR-214 was maximal at E12.5 and the miRNAs were expressed specifically in mouse cerebellum, midbrain, nasal process and fore- and hindlimb buds. This study shows the expression of the miR199a/214 cluster is controlled by Twist-1 via an E-Box promoter element and supports a role for these miRNAs as novel intermediates in the pathways controlling the development of specific neural cell populations.
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Cites
Tumour invasion and metastasis initiated by microRNA-10b in breast cancer
Ma, L., Teruya-Feldstein, J., & Weinberg, R. A. (2007) · Nature · doi:10.1038/nature06174 · Cited by 2,605
Direct regulation of TWIST by HIF-1α promotes metastasis
Yang, M.-H., Wu, M.-Z., Chiou, S.-H., Chen, P.-M., Chang, S.-Y., Liu, C.-J., Teng, S.-C., & Wu, K.-J. (2008) · Nature Cell Biology · doi:10.1038/ncb1691 · Cited by 1,345
Cited by
Mellios, N., Feldman, D. A., Sheridan, S. D., Ip, J. P. K., Kwok, S., Amoah, S. K., Rosen, B., Rodriguez, B. A., Crawford, B., Swaminathan, R., et al. (2018) · Molecular Psychiatry · doi:10.1038/mp.2017.86 · Cited by 292
MicroRNAs, new effectors and regulators of NF‐κB
Boldin, M. P., & Baltimore, D. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01089.x · Cited by 199
Wang, X., Zhang, H., Bai, M., Ning, T., Ge, S., Deng, T., Liu, R., Zhang, L., Ying, G., & Ba, Y. (2018) · Molecular Therapy · doi:10.1016/j.ymthe.2018.01.001 · Cited by 192
Metadata
- Authors
- Lee, Y.-B., Bantounas, I., Lee, D.-Y., Phylactou, L., Caldwell, M. A., & Uney, J. B.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-11-23
- Volume
- 37
- Issue
- 1
- Pages
- 123-128
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2138344908
- Cited by
- 226
- References
- 2
- FWCI
- 3.94
- Type
- journal article
- Language
- en
- Open access
- gold
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- Lee, Y.-B., Bantounas, I., Lee, D.-Y., Phylactou, L., Caldwell, M. A., & Uney, J. B. (2009). Twist-1 regulates the miR-199a/214 cluster during development. Nucleic Acids Research. https://doi.org/10.1093/nar/gkn920
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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