Cited by 2,605MicroRNA in disease regulationMechanisms of cancer metastasisCancer Cells and Metastasis

Tumour invasion and metastasis initiated by microRNA-10b in breast cancer

Ma, Li, Teruya-Feldstein, Julie, Weinberg, Robert A.·2007·Nature

Abstract

MicroRNAs have been implicated in regulating diverse cellular pathways. Although there is emerging evidence that some microRNAs can function as oncogenes or tumour suppressors, the role of microRNAs in mediating cancer metastasis remains unexplored. Here we show, using a combination of mouse and human cells, that microRNA-10b (miR-10b) is highly expressed in metastatic breast cancer cells and positively regulates cell migration and invasion. Overexpression of miR-10b in otherwise non-metastatic breast tumours initiates robust invasion and metastasis. Expression of miR-10b is induced by the transcription factor Twist, which binds directly to the putative promoter of mir-10b (MIRN10B). The miR-10b induced by Twist proceeds to inhibit translation of the messenger RNA encoding homeobox D10, resulting in increased expression of a well-characterized pro-metastatic gene, RHOC. Significantly, the level of miR-10b expression in primary breast carcinomas correlates with clinical progression. These findings suggest the workings of an undescribed regulatory pathway, in which a pleiotropic transcription factor induces expression of a specific microRNA, which suppresses its direct target and in turn activates another pro-metastatic gene, leading to tumour cell invasion and metastasis.

Integrity signals

Registry

Crossref · 10.1038/nature06174

Cites

48 of 48 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • miR-10b is often elevated in grade III and even grade II gliomas and dysregulated in some other cancers.

    “This expression pattern is different from those of the other cancer-associated miRNAs, for example, miR-10b, which is often elevated in grade III and even grade II gliomas (Fig. 1) and dysregulated in some other cancers (41).”

Cites

Flagged first, then by citations

1 of the 49 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Ma, L., Teruya-Feldstein, J., & Weinberg, R. A.
Affiliations
Whitehead Institute for Biomedical Research (US)
Corresponding author
Weinberg, Robert A.
Venue
Nature
Published
2007-09-26
Volume
449
Issue
7163
Pages
682-688
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
OpenAlex
W2047529648
Cited by
2,605
References
49
Citations by year
2026: 34 · 2025: 36 · 2024: 66 · 2023: 69 · 2022: 75 · 2021: 120 · 2020: 106 · 2019: 123 · 2018: 113 · 2017: 151 · 2016: 160 · 2015: 196 · 2014: 215 · 2013: 226 · 2012: 220
FWCI
60.84
Type
journal article
Language
en
Open access
closed
Locations
  • Nature (publishedVersion)
  • PubMed (publishedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mechanisms of cancer metastasis
  • Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Keywords
microRNA-10b, breast cancer, metastasis, tumor invasion, cell migration, Twist transcription factor, HOXD10, RhoC, Hox genes, microRNA target regulation, clinical progression
MeSH terms
rhoC GTP-Binding Protein, Animals, Base Sequence, Breast Neoplasms, Cell Movement, Humans, Lung Neoplasms, Neoplasm Invasiveness, Neoplasm Metastasis, Peritoneal Neoplasms, Transcription Factors, Gene Expression Regulation, Neoplastic, Homeodomain Proteins, rho GTP-Binding Proteins, MicroRNAs, Cell Line, Tumor, Mice, Twist-Related Protein 1

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review