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Real-time single-molecule observation of rolling-circle DNA replication
Open accessAbstract
We present a simple technique for visualizing replication of individual DNA molecules in real time. By attaching a rolling-circle substrate to a TIRF microscope-mounted flow chamber, we are able to monitor the progression of single-DNA synthesis events and accurately measure rates and processivities of single T7 and Escherichia coli replisomes as they replicate DNA. This method allows for rapid and precise characterization of the kinetics of DNA synthesis and the effects of replication inhibitors.
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Metadata
- Authors
- Tanner, N. A., Loparo, J. J., Hamdan, S. M., Jergic, S., Dixon, N. E., & van Oijen, A. M.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-01-20
- Volume
- 37
- Issue
- 4
- Pages
- e27-e27
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2108539496
- Cited by
- 1,279
- References
- 0
- FWCI
- 29.06
- Type
- journal article
- Language
- en
- Open access
- gold
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- Tanner, N. A., Loparo, J. J., Hamdan, S. M., Jergic, S., Dixon, N. E., & van Oijen, A. M. (2009). Real-time single-molecule observation of rolling-circle DNA replication. Nucleic Acids Research. https://doi.org/10.1093/nar/gkp006
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
