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Efficient gene silencing by delivery of locked nucleic acid antisense oligonucleotides, unassisted by transfection reagents
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The uptake of naked oligoribonucleotides (gymnosis) primarily by cell lines, but also primary neurons has been reported.
“the uptake of naked oligoribonucleotides, termed gymnosis [59, 60], primarily by cell lines, but also primary neurons has been reported [61, 62].”
From Neurodegenerative disease-associated microRNAs acting as signaling molecules modulate CNS neuron structure and viability (2025) · cites this paper as [59]
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Research works printed but not linked: 20
- Akhtar, 1991, Interactions of antisense DNA oligonucleotide analogs with phospholipid membranes (liposomes), Nucleic Acids Res., 19, 5551, 10.1093/nar/19.20.5551 · DOI
- Walder, 1988, Role of RNAse H in hybrid-arrested translation by antisense oligonucleotides, Proc. Natl Acad. Sci. USA, 85, 5011, 10.1073/pnas.85.14.5011 · DOI
- Marcusson, 1998, Phosphorothioate oligonucleotides dissociate from cationic lipids before entering the nucleus, Nucleic Acids Res., 26, 2016, 10.1093/nar/26.8.2016 · DOI
- Fisher, 1993, Intracellular disposition and metabolism of fluorescently-labeled unmodified and modified oligonucleotides microinjected into mammalian cells, Nucleic Acids Res., 21, 3857, 10.1093/nar/21.16.3857 · DOI
- Moulds, 1995, Site and mechanism of antisense inhibition of C-5 propyne oligonucleotides, Biochemistry, 34, 5044, 10.1021/bi00015a015 · DOI
- Flanagan, 1998, The development of C-5 propyne oligonucleotides as inhibitors of gene function, 175
- Benimetskaya, 2004, Relative Bcl-2 independence of drug induced cytotoxicity and resistance in 518A2 melanoma cells, Clin. Cancer Res., 10, 8371, 10.1158/1078-0432.CCR-04-1294 · DOI
- Koshkin, 1998, LNA (locked nucleic acids): synthesis of the adenine, cytosine, guanine, 5-methylcytosine, thymine and uracil bicyclonucleoside monomers, oligomerisation, and unprecedented nucleic acid recognition, Tetrahedron, 54, 3607, 10.1016/S0040-4020(98)00094-5 · DOI
- Singh, 1998, LNA (locked nucleic acids): synthesis and high-affinity nucleic acid recognition, 455
- Singh, 1998, Universality of LNA-medicated high-affinity nucleic acid recognition, 1247
- Koch, 2008, Locked nucleic acid: properties and therapeutic aspects, 103, 10.1039/9781847558275-00103 · DOI
- Akhtar, 2007, Toxicogenomics of non-viral drug delivery systems for RNAi: potential impact on siRNA-mediated gene silencing activity and specificity, Adv. Drug Deliv. Rev., 59, 164, 10.1016/j.addr.2007.03.010 · DOI
- Omidi, 2003, Toxicogenomics of non-viral vectors for gene therapy: a microarray study of lipofectin- and oligofectamine-induced gene expression changes in human epithelial cells, J. Drug. Target., 11, 311, 10.1080/10611860310001636908 · DOI
- Lai, 2005, Phosphorothioate oligodeoxynucleotides and G3139 induce apoptosis in 518A2 melanoma cells, Mol. Cancer Ther., 4, 305, 10.1158/1535-7163.305.4.2 · DOI
- Koch, 2008, Locked nucleic acid, 519
- Jakymiw, 2005, Disruption of GW bodies impairs mammalian RNA interference, Nat. Cell Biol., 7, 1267, 10.1038/ncb1334 · DOI
- Sen, 2005, Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies, Nat. Cell Biol., 7, 633, 10.1038/ncb1265 · DOI
- Dikmen, 2008, Telomerase targeted oligonucleotide thio-phosphoramidates in T24-luc bladder cancer cells, J. Cell. Biochem., 104, 444, 10.1002/jcb.21635 · DOI
- Ferrari, 2008, Characterization of antisense oligonucleotides comprising 2′-deoxy, 2′-fluoro-beta-D-arabinonucleic acid (FANA); specificity, potency and duration of activity, Ann. NY Acad. Sci., 1082, 91, 10.1196/annals.1348.032 · DOI
- Stein, 2009, G3139, an anti-Bcl-2 antisense oligomer that binds heparin-binding growth factors and collagen I, alters in vitro endothelial cell growth and tubular morphogenesis, Clin. Cancer Res., 15, 2797, 10.1158/1078-0432.CCR-08-2610 · DOI
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Metadata
- Authors
- Stein, C. A., Hansen, J. B., Lai, J., Wu, S., Voskresenskiy, A., H⊘g, A., Worm, J., Hedtjärn, M., Souleimanian, N., Miller, P., Soifer, H. S., Castanotto, D., Benimetskaya, L., Ørum, H., & Koch, T.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-10-23
- Volume
- 38
- Issue
- 1
- Pages
- e3-e3
- ISSN
- 0305-1048
- 1362-4962
- PMC
- PMC2800216
- Cited by
- 360
- References
- 0
- Language
- en
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