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BBB pathophysiology–independent delivery of siRNA in traumatic brain injury

Li, W., Qiu, J., Li, X.-L., Aday, S., Zhang, J., Conley, G., Xu, J., Joseph, J., Lan, H., Langer, R., et al. (2021) · Science Advances · doi:10.1126/sciadv.abd6889 · Cited by 160 · see citing works

Delivery of RNA Therapeutics: The Great Endosomal Escape!

Dowdy, S. F., Setten, R. L., Cui, X.-S., & Jadhav, S. G. (2022) · Nucleic Acid Therapeutics · doi:10.1089/nat.2022.0004 · Cited by 158 · see citing works

Chemical modifications of nucleic acid drugs and their delivery systems for gene‐based therapy

Chen, C., Yang, Z., & Tang, X. (2018) · Medicinal Research Reviews · doi:10.1002/med.21479 · Cited by 160 · see citing works

Endosomal escape of RNA therapeutics: How do we solve this rate-limiting problem?

Dowdy, S. F. (2023) · RNA · doi:10.1261/rna.079507.122 · Cited by 160 · see citing works

N6-Methyladenosine-modified circSAV1 triggers ferroptosis in COPD through recruiting YTHDF1 to facilitate the translation of IREB2

Xia, H., Wu, Y., Zhao, J., Cheng, C., Lin, J., Yang, Y., Lu, L., Xiang, Q., Bian, T., & Liu, Q. (2023) · Cell Death and Differentiation · doi:10.1038/s41418-023-01138-9 · Cited by 159 · see citing works

Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing

Andrews, B. I., Antia, F. D., Brueggemeier, S. B., Diorazio, L. J., Koenig, S. G., Kopach, M. E., Lee, H., Olbrich, M., & Watson, A. (2020) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.0c02291 · Cited by 156 · see citing works

A high-throughput Galectin-9 imaging assay for quantifying nanoparticle uptake, endosomal escape and functional RNA delivery

Munson, M. J., O’Driscoll, G., da Silva, A. M., Lázaro‐Ibáñez, E., Gallud, A., Wilson, J. T., Collén, A., Esbjörner, E. K., & Sabirsh, A. (2021) · Communications Biology · doi:10.1038/s42003-021-01728-8 · Cited by 156 · see citing works

Methodologies to Isolate and Purify Clinical Grade Extracellular Vesicles for Medical Applications

Akbar, A., Malekian, F., Baghban, N., Kodam, S. P., & Ullah, M. (2022) · Cells · doi:10.3390/cells11020186 · Cited by 154 · see citing works

Where should siRNAs go: applicable organs for siRNA drugs

Ahn, I., Kang, C. S., & Han, J. (2023) · Experimental & Molecular Medicine · doi:10.1038/s12276-023-00998-y · Cited by 151 · see citing works

Functional sequestration of microRNA-122 from Hepatitis C Virus by circular RNA sponges

Jost, I., Shalamova, L. A., Gerresheim, G. K., Niepmann, M., Bindereif, A., & Roßbach, O. (2018) · RNA Biology · doi:10.1080/15476286.2018.1435248 · Cited by 149 · see citing works

Gold Nanoparticles in Conjunction with Nucleic Acids as a Modern Molecular System for Cellular Delivery

Graczyk, A., Pawłowska, R., Jędrzejczyk, D., & Chworoś, A. (2020) · Molecules · doi:10.3390/molecules25010204 · Cited by 148 · see citing works

Editorial focus: understanding off-target effects as the key to successful RNAi therapy

Bartoszewski, R., & Sikorski, A. F. (2019) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-019-0196-3 · Cited by 150 · see citing works

Exosome for mRNA delivery: Strategies and therapeutic applications

Iqbal, Z., Rehman, K., Mahmood, A., Shabbir, M., Liang, Y., Duan, L., & Zeng, H. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02634-x · Cited by 144 · see citing works

The Phospholipid Research Center: Current Research in Phospholipids and Their Use in Drug Delivery

Drescher, S., & van Hoogevest, P. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12121235 · Cited by 150 · see citing works

MicroRNA-based therapeutics in cardiovascular disease: screening and delivery to the target

Mellis, D. J., & Caporali, A. (2017) · Biochemical Society Transactions · doi:10.1042/bst20170037 · Cited by 138 · see citing works

Improving siRNA Delivery <i>In Vivo</i> Through Lipid Conjugation

Osborn, M. F., & Khvorova, A. (2018) · Nucleic Acid Therapeutics · doi:10.1089/nat.2018.0725 · Cited by 137 · see citing works

Nanomaterials for Therapeutic RNA Delivery

Han, X., Mitchell, M. J., & Nie, G. (2020) · Matter · doi:10.1016/j.matt.2020.09.020 · Cited by 137 · see citing works

miR-145 micelles mitigate atherosclerosis by modulating vascular smooth muscle cell phenotype

Chin, D. D., Poon, C. J., Wang, J., Joo, J., Ong, V., Jiang, Z., Cheng, K., Plotkin, A., Magee, G. A., & Chung, E. J. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.120810 · Cited by 135 · see citing works

Design of lipid-based nanoparticles for delivery of therapeutic nucleic acids

Mendonça, M. C. P., Kont, A., Kowalski, P. S., & O’Driscoll, C. M. (2023) · Drug Discovery Today · doi:10.1016/j.drudis.2023.103505 · Cited by 137 · see citing works

The promise of microRNA-based therapies in Alzheimer’s disease: challenges and perspectives

Walgrave, H., Zhou, L., Strooper, B. D., & Salta, E. (2021) · Molecular Neurodegeneration · doi:10.1186/s13024-021-00496-7 · Cited by 132 · see citing works

Self-assembled peptide–poloxamine nanoparticles enable in vitro and in vivo genome restoration for cystic fibrosis

Guan, S., Munder, A., Hedtfeld, S., Braubach, P., Glage, S., Zhang, L., Lienenklaus, S., Schultze, A., Hasenpusch, G., Garrels, W., et al. (2019) · Nature Nanotechnology · doi:10.1038/s41565-018-0358-x · Cited by 130 · see citing works

Kim-1 Targeted Extracellular Vesicles: A New Therapeutic Platform for RNAi to Treat AKI

Tang, T., Wang, B., Li, Z., Wen, Y., Feng, S., Wu, M., Liu, D., Cao, J.-Y., Yin, Q., Yin, D., et al. (2021) · Journal of the American Society of Nephrology · doi:10.1681/asn.2020111561 · Cited by 128 · see citing works

How do oral insecticidal compounds cross the insect midgut epithelium?

Denecke, S., Swevers, L., Douris, V., & VONTAS, J. G. (2018) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2018.10.005 · Cited by 124 · see citing works

Biodegradable Cationic and Ionizable Cationic Lipids: A Roadmap for Safer Pharmaceutical Excipients

Jörgensen, A. M., Wibel, R., & Bernkop‐Schnürch, A. (2023) · Small · doi:10.1002/smll.202206968 · Cited by 127 · see citing works

Targeting RNA in mammalian systems with small molecules

Donlic, A., & Hargrove, A. E. (2018) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1477 · Cited by 122 · see citing works

Recent advances in the design and applications of near-infrared II responsive small molecule phototherapeutic agents

Ma, D., Bian, H., Gu, M., Wang, L., Chen, X., & Peng, X. (2024) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2024.215677 · Cited by 124 · see citing works

Intracellular Trafficking and Endosomal Release of Oligonucleotides: What We Know and What We Don’t

Juliano, R. L. (2018) · Nucleic Acid Therapeutics · doi:10.1089/nat.2018.0727 · Cited by 122 · see citing works

Gal8 Visualization of Endosome Disruption Predicts Carrier-Mediated Biologic Drug Intracellular Bioavailability

Kilchrist, K. V., Dimobi, S. C., Jackson, M. A., Evans, B. C., Werfel, T. A., Dailing, E. A., Bedingfield, S. K., Kelly, I. B., & Duvall, C. L. (2019) · ACS Nano · doi:10.1021/acsnano.8b05482 · Cited by 121 · see citing works

Extracellular vesicles as delivery systems at nano-/micro-scale

Fu, P., Zhang, J., Li, H., Mak, M., Xu, W., & Tao, Z. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.113910 · Cited by 120 · see citing works

Delivery of RNA Therapeutics: The Great Endosomal Escape!

Dowdy, S. F., Setten, R. L., Cui, X.-S., & Jadhav, S. G. (2022) · Nucleic Acid Therapeutics · doi:10.1089/nat.2022.0004 · Cited by 158 · see citing works

Different cellular barriers to RNA therapeutics and strategies to overcome

Chatterjee, S., Bhattacharya, M., Agoramoorthy, G., & Chakraborty, C. (2023) · International Journal of Surgery · doi:10.1097/js9.0000000000000090 · Cited by 2 · see citing works

Harnessing RNA molecules for therapy: advances in design, delivery, and clinical development

Zou, J., He, X., Li, Z., Song, B., Xing, X., Yu, J., & He, W. (2025) · Targetome · doi:10.48130/targetome-0025-0003 · Cited by 6 · see citing works

RNA therapeutics: updates and future potential

Zhang, C., & Zhang, B. (2022) · Science China Life Sciences · doi:10.1007/s11427-022-2171-2 · Cited by 122 · see citing works

Recent Advances in RNA Therapeutics and RNA Delivery Systems Based on Nanoparticles

Shin, H., Park, S. D., Yim, Y., Kim, J., Choi, C., Won, C., & Min, D. (2018) · Advanced Therapeutics · doi:10.1002/adtp.201800065 · Cited by 91 · see citing works