The NCBI BioSystems database
Open accessAbstract
The NCBI BioSystems database, found at http://www.ncbi.nlm.nih.gov/biosystems/, centralizes and cross-links existing biological systems databases, increasing their utility and target audience by integrating their pathways and systems into NCBI resources. This integration allows users of NCBI's Entrez databases to quickly categorize proteins, genes and small molecules by metabolic pathway, disease state or other BioSystem type, without requiring time-consuming inference of biological relationships from the literature or multiple experimental datasets.
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The human and mouse genomes are both nearly 3 gigabases.
“Though the commonly analyzed human and mouse genome are both nearly 3 gigabases13, approximately two orders of magnitude fewer bases than examined in this work’s most complex condition, genomic libraries are often exceedingly complex because of the genome fragmentation process.”
From Probing the physical limits of reliable DNA data retrieval. (2020) · cites this paper as [13]
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- Authors
- Geer, L. Y., Marchler-Bauer, A., Geer, R. C., Han, L., He, J., He, S., Liu, C., Shi, W., & Bryant, S. H.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Geer, Lewis Y.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-10-23
- Volume
- 38
- Issue
- suppl_1
- Pages
- D492-D496
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- PMC
- PMC2808896
- OpenAlex
- W2013469333
- Cited by
- 875
- References
- 15
- Citations by year
- 2026: 28 · 2025: 52 · 2024: 44 · 2023: 47 · 2022: 63 · 2021: 76 · 2020: 79 · 2019: 79 · 2018: 57 · 2017: 67 · 2016: 62 · 2015: 65 · 2014: 55 · 2013: 41 · 2012: 25
- FWCI
- 7.91
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nucleic Acids Research (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- U.S. Department of Health and Human Services
- National Institutes of Health
- U.S. National Library of Medicine
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biomedical Text Mining and Ontologies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Keywords
- metabolic pathways, pathway integration, disease states, small molecules
- MeSH terms
- Animals, Cell Membrane, Genes, Humans, National Library of Medicine (U.S.), Software, United States, Information Storage and Retrieval, Computational Biology, Internet, Genomics, Databases, Genetic, Databases, Nucleic Acid, Databases, Protein, Systems Biology
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