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CORUM: the comprehensive resource of mammalian protein complexes—2009

Open access
Ruepp, Andreas, Waegele, Brigitte, Lechner, Martin, Brauner, Barbara, Dunger-Kaltenbach, Irmtraud, Fobo, Gisela, Frishman, Goar, Montrone, Corinna, Mewes, H.-Werner·2010·Nucleic Acids Research

Abstract

CORUM is a database that provides a manually curated repository of experimentally characterized protein complexes from mammalian organisms, mainly human (64%), mouse (16%) and rat (12%). Protein complexes are key molecular entities that integrate multiple gene products to perform cellular functions. The new CORUM 2.0 release encompasses 2837 protein complexes offering the largest and most comprehensive publicly available dataset of mammalian protein complexes. The CORUM dataset is built from 3198 different genes, representing approximately 16% of the protein coding genes in humans. Each protein complex is described by a protein complex name, subunit composition, function as well as the literature reference that characterizes the respective protein complex. Recent developments include mapping of functional annotation to Gene Ontology terms as well as cross-references to Entrez Gene identifiers. In addition, a 'Phylogenetic Conservation' analysis tool was implemented that analyses the potential occurrence of orthologous protein complex subunits in mammals and other selected groups of organisms. This allows one to predict the occurrence of protein complexes in different phylogenetic groups. CORUM is freely accessible at (http://mips.helmholtz-muenchen.de/genre/proj/corum/index.html).

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Metadata

Authors
Ruepp, A., Waegele, B., Lechner, M., Brauner, B., Dunger-Kaltenbach, I., Fobo, G., Frishman, G., Montrone, C., & Mewes, H.-W.
Venue
Nucleic Acids Research
Published
2009-10-31
Volume
38
Issue
suppl_1
Pages
D497-D501
ISSN
  • 0305-1048 (ISSN-L)
  • 1362-4962
OpenAlex
W2148043260
Cited by
1,310
References
50
FWCI
17.04
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: CORUM: the comprehensive resource of mammalian protein complexes—2009. https://app.cochat.ai/papers/10.1093/nar/gkp914
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Ruepp, A., Waegele, B., Lechner, M., Brauner, B., Dunger-Kaltenbach, I., Fobo, G., Frishman, G., Montrone, C., & Mewes, H.-W. (2010). CORUM: the comprehensive resource of mammalian protein complexes—2009. Nucleic Acids Research. https://doi.org/10.1093/nar/gkp914

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