The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
miRTarBase: a database curates experimentally validated microRNA–target interactions
Open accessAbstract
MicroRNAs (miRNAs), i.e. small non-coding RNA molecules (∼22 nt), can bind to one or more target sites on a gene transcript to negatively regulate protein expression, subsequently controlling many cellular mechanisms. A current and curated collection of miRNA-target interactions (MTIs) with experimental support is essential to thoroughly elucidating miRNA functions under different conditions and in different species. As a database, miRTarBase has accumulated more than 3500 MTIs by manually surveying pertinent literature after data mining of the text systematically to filter research articles related to functional studies of miRNAs. Generally, the collected MTIs are validated experimentally by reporter assays, western blot, or microarray experiments with overexpression or knockdown of miRNAs. miRTarBase curates 3576 experimentally verified MTIs between 657 miRNAs and 2297 target genes among 17 species. miRTarBase contains the largest amount of validated MTIs by comparing with other similar, previously developed databases. The MTIs collected in the miRTarBase can also provide a large amount of positive samples to develop computational methods capable of identifying miRNA-target interactions. miRTarBase is now available on http://miRTarBase.mbc.nctu.edu.tw/, and is updated frequently by continuously surveying research articles.
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Cites
Combinatorial microRNA target predictions
Krek, A., Grün, D., Poy, M. N., Wolf, R., Rosenberg, L., Epstein, E. J., MacMenamin, P., da Piedade, I., Gunsalus, K. C., Stoffel, M., et al. (2005) · Nature Genetics · doi:10.1038/ng1536 · Cited by 4,603
Wightman, B., Ha, I., & Ruvkun, G. (1993) · Cell · doi:10.1016/0092-8674(93)90530-4 · Cited by 4,292
Widespread changes in protein synthesis induced by microRNAs
Selbach, M., Schwanhäusser, B., Thierfelder, N., Fang, Z., Khanin, R., & Rajewsky, N. (2008) · Nature · doi:10.1038/nature07228 · Cited by 3,429 · cited 1×
“For instance, Selbach et al. determined the complement of all genes targeted by five miRNAs induced independently in HeLa cells using microarrays and pSILAC (17).”
MethodThe role of site accessibility in microRNA target recognition
Kertesz, M., Iovino, N., Unnerstall, U., Gaul, U., & Segal, E. (2007) · Nature Genetics · doi:10.1038/ng2135 · Cited by 2,460
Cited by
Li, J.-H., Liu, S., Zhou, H., Qu, L.-H., & Yang, J.-H. (2014) · Nucleic Acids Research · doi:10.1093/nar/gkt1248 · Cited by 4,686
Rouillard, A. D., Gundersen, G. W., Fernandez, N. F., Wang, Z., Monteiro, C. D., McDermott, M. G., & Ma’ayan, A. (2016) · Database · doi:10.1093/database/baw100 · Cited by 1,515
Mapping the Human miRNA Interactome by CLASH Reveals Frequent Noncanonical Binding
Helwak, A., Kudla, G., Dudnakova, T., & Tollervey, D. (2013) · Cell · doi:10.1016/j.cell.2013.03.043 · Cited by 1,269
miRTarBase 2020: updates to the experimentally validated microRNA–target interaction database
Huang, H.-Y., Lin, Y.-C.-D., Li, J., Huang, K.-Y., Shrestha, S., Hong, H.-C., Tang, Y., Chen, Y.-G., Jin, C.-N., Yu, Y., et al. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz896 · Cited by 1,259
Self-citationHMDD v2.0: a database for experimentally supported human microRNA and disease associations
Li, Y., Qiu, C., Tu, J., Geng, B., Yang, J., Jiang, T., & Cui, Q. (2014) · Nucleic Acids Research · doi:10.1093/nar/gkt1023 · Cited by 1,160
Metadata
- Authors
- Hsu, S.-D., Lin, F.-M., Wu, W.-Y., Liang, C., Huang, W.-C., Chan, W.-L., Tsai, W.-T., Chen, G.-Z., Lee, C.-J., Chiu, C.-M., Chien, C.-H., Wu, M.-C., Huang, C.-Y., Tsou, A.-P., & Huang, H.-D.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-11-10
- Volume
- 39
- Issue
- suppl_1
- Pages
- D163-D169
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2053835153
- Cited by
- 1,389
- References
- 4
- FWCI
- 16.08
- Type
- journal article
- Language
- en
- Open access
- gold
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- Hsu, S.-D., Lin, F.-M., Wu, W.-Y., Liang, C., Huang, W.-C., Chan, W.-L., Tsai, W.-T., Chen, G.-Z., Lee, C.-J., Chiu, C.-M., Chien, C.-H., Wu, M.-C., Huang, C.-Y., Tsou, A.-P., & Huang, H.-D. (2011). miRTarBase: a database curates experimentally validated microRNA–target interactions. Nucleic Acids Research. https://doi.org/10.1093/nar/gkq1107
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