The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
SIREs: searching for iron-responsive elements
Open accessAbstract
The iron regulatory protein/iron-responsive element regulatory system plays a crucial role in the post-transcriptional regulation of gene expression and its disruption results in human disease. IREs are cis-acting regulatory motifs present in mRNAs that encode proteins involved in iron metabolism. They function as binding sites for two related trans-acting factors, namely the IRP-1 and -2. Among cis-acting RNA regulatory elements, the IRE is one of the best characterized. It is defined by a combination of RNA sequence and structure. However, currently available programs to predict IREs do not show a satisfactory level of sensitivity and fail to detect some of the functional IREs. Here, we report an improved software for the prediction of IREs implemented as a user-friendly web server tool. The SIREs web server uses a simple data input interface and provides structure analysis, predicted RNA folds, folding energy data and an overall quality flag based on properties of well characterized IREs. Results are reported in a tabular format and as a schematic visual representation that highlights important features of the IRE. The SIREs (Search for iron-responsive elements) web server is freely available on the web at http://ccbg.imppc.org/sires/index.html.
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“IRPs most likely regulate the immune response in an indirect manner since the transcripts encoding the cytokines assayed in our study are devoid of IRE, as assessed using the sIRES tool (Campillos et al., 2010).”
From Iron Regulatory Proteins Mediate Host Resistance to Salmonella Infection (2015) · cites this paper as Campillos et al., 2010
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Cloning and characterization of a mammalian proton-coupled metal-ion transporter
Gunshin, H., Mackenzie, B., Berger, U. V., Gunshin, Y., Romero, M. F., Boron, W. F., Nussberger, S., Gollan, J. L., & Hediger, M. A. (1997) · Nature · doi:10.1038/41343 · Cited by 3,166
Gruber, A. R., Lorenz, R., Bernhart, S. H., Neuböck, R., & Hofacker, I. L. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn188 · Cited by 2,717
McKie, A. T., Marciani, P., Rolfs, A., Brennan, K., Wehr, K., Barrow, D., Miret, S., Bomford, A., Peters, T. J., Farzaneh, F., et al. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80425-6 · Cited by 1,422
Self-citationMuckenthaler, M. U., Galy, B., & Hentze, M. W. (2008) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.28.061807.155521 · Cited by 701
Rogers, J. T., Randall, J. D., Cahill, C. M., Eder, P. S., Huang, X., Gunshin, H., Leiter, L., McPhee, J., Sarang, S. S., Utsuki, T., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207435200 · Cited by 551
RNAMotif, an RNA secondary structure definition and search algorithm
Macke, T. J. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.22.4724 · Cited by 469
Dandekar, T., Stripecke, R., Gray, N. K., Goossen, B., Constable, A., Johansson, H. E., & Hentze, M. W. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb07716.x · Cited by 347
Muckenthaler, M., Gray, N. K., & Hentze, M. W. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80282-8 · Cited by 297
Iron-regulatory proteins limit hypoxia-inducible factor-2α expression in iron deficiency
Sanchez, M., Galy, B., Muckenthaler, M. U., & Hentze, M. W. (2007) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1222 · Cited by 294
Self-citationPost-transcriptional control of gene expression: a genome-wide perspective
Mata, J., Marguerat, S., & Bähler, J. (2005) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2005.07.005 · Cited by 293
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Dong, Y., Newman, M., Pederson, S., Barthelson, K., Hin, N., & Lardelli, M. T. (2021) · Figshare · doi:10.6084/m9.figshare.14299317
Role of iron regulatory proteins in the regulation of iron metabolism by nitric oxide
Stys, A. (2011) · theses.fr (ABES) · doi:10.70675/e4192fa6z4401z465fzbe01zd45118568a2f
ARID5A RNA-binding coordinates microglial defense and ferroptosis in iPSC-derived models
Schafer, D. M., Blue, S. M., Xu, S., Mizrahi, O., Gosztyla, M. L., Street, L., Rothamel, K. L., Kopalle, H., Landry, S. B., Rosales, E. K. F., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-76131-0
Metadata
- Authors
- Campillos, M., Cases, I., Hentze, M. W., & Sanchez, M.
- Affiliations
- European Molecular Biology Laboratory (DE)
- European Molecular Biology Laboratory (ES)
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-05-11
- Volume
- 38
- Issue
- Web Server
- Pages
- W360-W367
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- PMC
- PMC2896125
- OpenAlex
- W1967604392
- Cited by
- 102
- References
- 31
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 8 · 2023: 7 · 2022: 1 · 2021: 19 · 2020: 9 · 2019: 3 · 2018: 6 · 2017: 5 · 2016: 2 · 2015: 7 · 2014: 6 · 2013: 3 · 2012: 6
- FWCI
- 2.46
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nucleic Acids Research (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Hispana (publishedVersion, cc-by-nc)
- HighWire Press Open Archive (submittedVersion)
- Funders
- Ministerio de Ciencia e Innovación (RYC-2008-02352)
- Instituto de Salud Carlos III
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Keywords
- iron-responsive element, iron regulatory proteins, post-transcriptional regulation, RNA secondary structure prediction, web server, iron metabolism
- MeSH terms
- Algorithms, Binding Sites, Humans, Iron, Nucleic Acid Conformation, RNA, Software, Internet, Untranslated Regions, Iron-Regulatory Proteins, Regulatory Sequences, Ribonucleic Acid
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