Hentze, Matthias W.

Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins

Castello, A., Fischer, B., Eichelbaum, K., Horos, R., Beckmann, B. M., Strein, C., Davey, N. E., Humphreys, D. T., Preiss, T., Steinmetz, L. M., et al. (2012) · Cell

RNA Research and SplicingRNA and protein synthesis mechanisms

Cited by 2,132

Two to tango: Regulation of Mammalian iron metabolism

Hentze, M. W., Muckenthaler, M. U., Galy, B., & Camaschella, C. (2010) · Cell

Iron Metabolism and DisordersFerroptosis and cancer prognosis

Cited by 2,120

Balancing Acts

Hentze, M. W., Muckenthaler, M. U., & Andrews, N. C. (2004) · Cell

Iron Metabolism and DisordersNeurological diseases and metabolism

Cited by 1,736

A Novel Duodenal Iron-Regulated Transporter, IREG1, Implicated in the Basolateral Transfer of Iron to the Circulation

McKie, A. T., Marciani, P., Rolfs, A., Brennan, K., Wehr, K., Barrow, D., Miret, S., Bomford, A., Peters, T. J., Farzaneh, F., et al. (2000) · Molecular Cell

Iron Metabolism and DisordersTrace Elements in Health

Cited by 1,422

A Red carpet for iron metabolism

Muckenthaler, M. U., Rivella, S., Hentze, M. W., & Galy, B. (2017) · Cell

Iron Metabolism and DisordersErythropoietin and Anemia Treatment

Cited by 1,319

Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress.

Hentze, M. W., & Kühn, L. C. (1996) · Proceedings of the National Academy of Sciences

Iron Metabolism and DisordersTrace Elements in Health

Cited by 1,292

Molecular mechanisms of translational control

Gebauer, F., & Hentze, M. W. (2004) · Nature Reviews Molecular Cell Biology

RNA and protein synthesis mechanismsPI3K/AKT/mTOR signaling in cancer

Cited by 991

Iron-Responsive Elements: Regulatory RNA Sequences That Control mRNA Levels and Translation

Casey, J. L., Hentze, M. W., Koeller, D. M., Caughman, S. W., Rouault, T. A., Klausner, R. D., & Harford, J. B. (1988) · Science

Iron Metabolism and DisordersRNA and protein synthesis mechanisms

Cited by 709

Systemic iron homeostasis and the iron-responsive element/iron-regulatory protein (IRE/IRP) regulatory network

Muckenthaler, M. U., Galy, B., & Hentze, M. W. (2008) · Annual Review of Nutrition

Iron Metabolism and DisordersTrace Elements in Health

Cited by 701

Identification of the iron-responsive element for the translational regulation of human ferritin mRNA

Hentze, M. W., Caughman, S. W., Rouault, T. A., Barriocanal, J. G., Dancis, A., Harford, J. B., & Klausner, R. D. (1987) · Science

Iron Metabolism and DisordersRNA and protein synthesis mechanisms

Cited by 571

STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation

Verga Falzacappa, M. V., Vujic Spasic, M., Kessler, R., Stolte, J., Hentze, M. W., & Muckenthaler, M. U. (2007) · Blood

Iron Metabolism and DisordersCytokine Signaling Pathways and Interactions

Cited by 567

Circular RNAs: splicing’s enigma variations

Hentze, M. W., & Preiss, T. (2013) · The EMBO Journal

Circular RNAs in diseasesRNA Research and Splicing

Cited by 455

Serum ferritin is derived primarily from macrophages through a nonclassical secretory pathway

Cohen, L. A., Gutierrez, L., Weiss, A., Leichtmann-Bardoogo, Y., Zhang, D.-L., Crooks, D. R., Sougrat, R., Morgenstern, A., Galy, B., Hentze, M. W., et al. (2010) · Blood

Iron Metabolism and DisordersNeurological diseases and metabolism

Cited by 452

Previously uncharacterized isoforms of divalent metal transporter (DMT)-1: Implications for regulation and cellular function

Hubert, N., & Hentze, M. W. (2002) · Proceedings of the National Academy of Sciences

Iron Metabolism and DisordersTrace Elements in Health

Cited by 428

Iron regulates nitric oxide synthase activity by controlling nuclear transcription.

Weiss, G., Werner-Felmayer, G., Werner, E. R., Grünewald, K., Wachter, H., & Hentze, M. W. (1994) · The Journal of experimental medicine

Iron Metabolism and DisordersNitric Oxide and Endothelin Effects

Cited by 412

Binary specification of nonsense codons by splicing and cytoplasmic translation

Thermann, R., Neu‐Yilik, G., Deters, A., Frede, U., Wehr, K., Hagemeier, C., Hentze, M. W., & Kulozik, A. E. (1998) · The EMBO Journal

RNA Research and SplicingRNA and protein synthesis mechanisms

Cited by 406

Translational regulation via iron‐responsive elements by the nitric oxide/NO‐synthase pathway.

Weiss, G., Goossen, B., Doppler, W., Fuchs, D., Pantopoulos, K., Werner‐Felmayer, G., Wachter, H., & Hentze, M. W. (1993) · The EMBO Journal

Iron Metabolism and DisordersNitric Oxide and Endothelin Effects

Cited by 389

Binding of a Cytosolic Protein to the Iron-Responsive Element of Human Ferritin Messenger RNA

Rouault, T. A., Hentze, M. W., Caughman, S. W., Harford, J. B., & Klausner, R. D. (1988) · Science

Iron Metabolism and DisordersRNA and protein synthesis mechanisms

Cited by 351

Iron-dependent regulation of the divalent metal ion transporter

Gunshin, H., Allerson, C. R., Polycarpou-Schwarz, M., Rofts, A., Rogers, J. T., Kishi, F., Hentze, M. W., Rouault, T. A., Andrews, N. C., & Hediger, M. A. (2001) · FEBS Letters

Iron Metabolism and DisordersTrace Elements in Health

Cited by 305

IRP-1 binding to ferritin mRNA prevents the recruitment of the small ribosomal subunit by the cap-binding complex eIF4F.

Muckenthaler, M., Gray, N. K., & Hentze, M. W. (1998) · Molecular Cell

RNA and protein synthesis mechanismsIron Metabolism and Disorders

Cited by 297

3′ end mRNA processing: molecular mechanisms and implications for health and disease

Danckwardt, S., Hentze, M. W., & Kulozik, A. E. (2008) · The EMBO Journal

RNA Research and SplicingRNA regulation and disease

Cited by 296

Iron-regulatory proteins limit hypoxia-inducible factor-2α expression in iron deficiency

Sanchez, M., Galy, B., Muckenthaler, M. U., & Hentze, M. W. (2007) · Nature Structural & Molecular Biology

Iron Metabolism and DisordersErythropoietin and Anemia Treatment

Cited by 294

Iron regulatory protein prevents binding of the 43S translation pre‐initiation complex to ferritin and eALAS mRNAs.

Gray, N. K., & Hentze, M. W. (1994) · The EMBO Journal

Iron Metabolism and DisordersRNA and protein synthesis mechanisms

Cited by 276

A cis-acting element is necessary and sufficient for translational regulation of human ferritin expression in response to iron.

Hentze, M. W., Rouault, T. A., Caughman, S. W., Dancis, A., Harford, J. B., & Klausner, R. D. (1987) · Proceedings of the National Academy of Sciences

Iron Metabolism and DisordersRNA and protein synthesis mechanisms

Cited by 249