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Babelomics: an integrative platform for the analysis of transcriptomics, proteomics and genomic data with advanced functional profiling

Open access
Medina, Ignacio, Carbonell, Jos�, Pulido, Luis, Madeira, Sara C., Goetz, Stefan, Conesa, Ana, T�rraga, Joaqu�n, Pascual-Montano, Alberto, Nogales-Cadenas, Ruben, Santoyo, Javier, Garc�a, Francisco, Marb�, Martina, Montaner, David, Dopazo, Joaqu�n·2010·Nucleic Acids Research

Abstract

Babelomics is a response to the growing necessity of integrating and analyzing different types of genomic data in an environment that allows an easy functional interpretation of the results. Babelomics includes a complete suite of methods for the analysis of gene expression data that include normalization (covering most commercial platforms), pre-processing, differential gene expression (case-controls, multiclass, survival or continuous values), predictors, clustering; large-scale genotyping assays (case controls and TDTs, and allows population stratification analysis and correction). All these genomic data analysis facilities are integrated and connected to multiple options for the functional interpretation of the experiments. Different methods of functional enrichment or gene set enrichment can be used to understand the functional basis of the experiment analyzed. Many sources of biological information, which include functional (GO, KEGG, Biocarta, Reactome, etc.), regulatory (Transfac, Jaspar, ORegAnno, miRNAs, etc.), text-mining or protein-protein interaction modules can be used for this purpose. Finally a tool for the de novo functional annotation of sequences has been included in the system. This provides support for the functional analysis of non-model species. Mirrors of Babelomics or command line execution of their individual components are now possible. Babelomics is available at http://www.babelomics.org.

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Metadata

Authors
Medina, I., Carbonell, J., Pulido, L., Madeira, S. C., Goetz, S., Conesa, A., T�rraga, J., Pascual-Montano, A., Nogales-Cadenas, R., Santoyo, J., Garc�a, F., Marb�, M., Montaner, D., & Dopazo, J.
Venue
Nucleic Acids Research
Published
2010-05-15
Volume
38
Issue
suppl_2
Pages
W210-W213
ISSN
  • 0305-1048 (ISSN-L)
  • 1362-4962
OpenAlex
W2013318867
Cited by
322
References
5
FWCI
14.30
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Babelomics: an integrative platform for the analysis of transcriptomics, proteomics and genomic data with advanced functional profiling. https://app.cochat.ai/papers/10.1093/nar/gkq388
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Medina, I., Carbonell, J., Pulido, L., Madeira, S. C., Goetz, S., Conesa, A., T�rraga, J., Pascual-Montano, A., Nogales-Cadenas, R., Santoyo, J., Garc�a, F., Marb�, M., Montaner, D., & Dopazo, J. (2010). Babelomics: an integrative platform for the analysis of transcriptomics, proteomics and genomic data with advanced functional profiling. Nucleic Acids Research. https://doi.org/10.1093/nar/gkq388

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.