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MITE-Hunter: a program for discovering miniature inverted-repeat transposable elements from genomic sequences

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Han, Y., Wessler, S. R.·2010·Nucleic Acids Research

Abstract

Miniature inverted-repeat transposable elements (MITEs) are a special type of Class 2 non-autonomous transposable element (TE) that are abundant in the non-coding regions of the genes of many plant and animal species. The accurate identification of MITEs has been a challenge for existing programs because they lack coding sequences and, as such, evolve very rapidly. Because of their importance to gene and genome evolution, we developed MITE-Hunter, a program pipeline that can identify MITEs as well as other small Class 2 non-autonomous TEs from genomic DNA data sets. The output of MITE-Hunter is composed of consensus TE sequences grouped into families that can be used as a library file for homology-based TE detection programs such as RepeatMasker. MITE-Hunter was evaluated by searching the rice genomic database and comparing the output with known rice TEs. It discovered most of the previously reported rice MITEs (97.6%), and found sixteen new elements. MITE-Hunter was also compared with two other MITE discovery programs, FINDMITE and MUST. Unlike MITE-Hunter, neither of these programs can search large genomic data sets including whole genome sequences. More importantly, MITE-Hunter is significantly more accurate than either FINDMITE or MUST as the vast majority of their outputs are false-positives.

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Metadata

Authors
Han, Y., & Wessler, S. R.
Venue
Nucleic Acids Research
Published
2010-09-29
Volume
38
Issue
22
Pages
e199-e199
ISSN
  • 0305-1048 (ISSN-L)
  • 1362-4962
OpenAlex
W2134783286
Cited by
631
References
2
FWCI
11.28
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: MITE-Hunter: a program for discovering miniature inverted-repeat transposable elements from genomic sequences. https://app.cochat.ai/papers/10.1093/nar/gkq862
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Han, Y., & Wessler, S. R. (2010). MITE-Hunter: a program for discovering miniature inverted-repeat transposable elements from genomic sequences. Nucleic Acids Research. https://doi.org/10.1093/nar/gkq862

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