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SMART 7: recent updates to the protein domain annotation resource

Open access
Letunic, I., Doerks, T., Bork, P.·2012·Nucleic Acids Research

Abstract

SMART (Simple Modular Architecture Research Tool) is an online resource (http://smart.embl.de/) for the identification and annotation of protein domains and the analysis of protein domain architectures. SMART version 7 contains manually curated models for 1009 protein domains, 200 more than in the previous version. The current release introduces several novel features and a streamlined user interface resulting in a faster and more comfortable workflow. The underlying protein databases were greatly expanded, resulting in a 2-fold increase in number of annotated domains and features. The database of completely sequenced genomes now includes 1133 species, compared to 630 in the previous release. Domain architecture analysis results can now be exported and visualized through the iTOL phylogenetic tree viewer. 'metaSMART' was introduced as a novel subresource dedicated to the exploration and analysis of domain architectures in various metagenomics data sets. An advanced full text search engine was implemented, covering the complete annotations for SMART and Pfam domains, as well as the complete set of protein descriptions, allowing users to quickly find relevant information.

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Metadata

Authors
Letunic, I., Doerks, T., & Bork, P.
Venue
Nucleic Acids Research
Published
2011-11-03
Volume
40
Issue
D1
Pages
D302-D305
ISSN
  • 0305-1048 (ISSN-L)
  • 1362-4962
OpenAlex
W2052002049
Cited by
1,721
References
3
FWCI
66.89
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: SMART 7: recent updates to the protein domain annotation resource. https://app.cochat.ai/papers/10.1093/nar/gkr931
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Letunic, I., Doerks, T., & Bork, P. (2012). SMART 7: recent updates to the protein domain annotation resource. Nucleic Acids Research. https://doi.org/10.1093/nar/gkr931

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