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Cited by 344

The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

Expression Atlas update—a database of gene and transcript expression from microarray- and sequencing-based functional genomics experiments

Open access
Petryszak, Robert, Burdett, Tony, Fiorelli, Benedetto, Fonseca, Nuno A., Gonzalez-Porta, Mar, Hastings, Emma, Huber, Wolfgang, Jupp, Simon, Keays, Maria, Kryvych, Nataliya, McMurry, Julie, Marioni, John C., Malone, James, Megy, Karine, Rustici, Gabriella, Tang, Amy Y., Taubert, Jan, Williams, Eleanor, Mannion, Oliver, Parkinson, Helen E., Brazma, Alvis·2014·Nucleic Acids Research

Abstract

Expression Atlas (http://www.ebi.ac.uk/gxa) is a value-added database providing information about gene, protein and splice variant expression in different cell types, organism parts, developmental stages, diseases and other biological and experimental conditions. The database consists of selected high-quality microarray and RNA-sequencing experiments from ArrayExpress that have been manually curated, annotated with Experimental Factor Ontology terms and processed using standardized microarray and RNA-sequencing analysis methods. The new version of Expression Atlas introduces the concept of 'baseline' expression, i.e. gene and splice variant abundance levels in healthy or untreated conditions, such as tissues or cell types. Differential gene expression data benefit from an in-depth curation of experimental intent, resulting in biologically meaningful 'contrasts', i.e. instances of differential pairwise comparisons between two sets of biological replicates. Other novel aspects of Expression Atlas are its strict quality control of raw experimental data, up-to-date RNA-sequencing analysis methods, expression data at the level of gene sets, as well as genes and a more powerful search interface designed to maximize the biological value provided to the user.

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Metadata

Authors
Petryszak, R., Burdett, T., Fiorelli, B., Fonseca, N. A., Gonzalez-Porta, M., Hastings, E., Huber, W., Jupp, S., Keays, M., Kryvych, N., McMurry, J., Marioni, J. C., Malone, J., Megy, K., Rustici, G., Tang, A. Y., Taubert, J., Williams, E., Mannion, O., Parkinson, H. E., & Brazma, A.
Venue
Nucleic Acids Research
Published
2013-12-04
Volume
42
Issue
D1
Pages
D926-D932
ISSN
  • 0305-1048 (ISSN-L)
  • 1362-4962
OpenAlex
W2058320302
Cited by
344
References
6
FWCI
19.23
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Expression Atlas update—a database of gene and transcript expression from microarray- and sequencing-based functional genomics experiments. https://app.cochat.ai/papers/10.1093/nar/gkt1270
The paper
Petryszak, R., Burdett, T., Fiorelli, B., Fonseca, N. A., Gonzalez-Porta, M., Hastings, E., Huber, W., Jupp, S., Keays, M., Kryvych, N., McMurry, J., Marioni, J. C., Malone, J., Megy, K., Rustici, G., Tang, A. Y., Taubert, J., Williams, E., Mannion, O., . . . Brazma, A. (2014). Expression Atlas update—a database of gene and transcript expression from microarray- and sequencing-based functional genomics experiments. Nucleic Acids Research. https://doi.org/10.1093/nar/gkt1270

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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