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MEROPS: the database of proteolytic enzymes, their substrates and inhibitors

Open access
Rawlings, Neil D., Waller, Matthew, Barrett, Alan J., Bateman, Alex·2014·Nucleic Acids Research

Abstract

Peptidases, their substrates and inhibitors are of great relevance to biology, medicine and biotechnology.The MEROPS database (http://merops. sanger.ac.uk) aims to fulfill the need for an integrated source of information about these.The database has hierarchical classifications in which homologous sets of peptidases and protein inhibitors are grouped into protein species, which are grouped into families, which are in turn grouped into clans.Recent developments include the following.A community annotation project has been instigated in which acknowledged experts are invited to contribute summaries for peptidases.Software has been written to provide an Internetbased data entry form.Contributors are acknowledged on the relevant web page.A new display showing the intron/exon structures of eukaryote peptidase genes and the phasing of the junctions has been implemented.It is now possible to filter the list of peptidases from a completely sequenced bacterial genome for a particular strain of the organism.The MEROPS filing pipeline has been altered to circumvent the restrictions imposed on non-interactive blastp searches, and a HMMER search using specially generated alignments to maximize the distribution of organisms returned in the search results has been added.

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Metadata

Authors
Rawlings, N. D., Waller, M., Barrett, A. J., & Bateman, A.
Venue
Nucleic Acids Research
Published
2013-10-23
Volume
42
Issue
D1
Pages
D503-D509
ISSN
  • 0305-1048 (ISSN-L)
  • 1362-4962
OpenAlex
W4230386739
Cited by
873
References
22
FWCI
32.18
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: MEROPS: the database of proteolytic enzymes, their substrates and inhibitors. https://app.cochat.ai/papers/10.1093/nar/gkt953
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Rawlings, N. D., Waller, M., Barrett, A. J., & Bateman, A. (2014). MEROPS: the database of proteolytic enzymes, their substrates and inhibitors. Nucleic Acids Research. https://doi.org/10.1093/nar/gkt953

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