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Lessons from miR-143/145: the importance of cell-type localization of miRNAs

Kent, Oliver A., McCall, Matthew N., Cornish, Toby C., Halushka, Marc K.·2014·Nucleic Acids Research
DOI 10.1093/nar/gku461PMC PMC4081080
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  • Analyses of global tissue microRNA expression require an understanding of the source of each microRNA of interest, lest misinterpretations result in spurious disease associations.

    “These data further support the cell-type restricted microRNAs seen above and indicate that analyses of global tissue microRNA expression require an understanding of the source of each microRNA of interest, lest misinterpretations of the data result in spurious disease associations (Kent et al. 2014).”

    From Toward the human cellular microRNAome (2017) · cites this paper as Kent et al. 2014

  • This will improve the interpretation of tissue microRNA expression levels.

    “This will improve the interpretation of tissue microRNA expression levels, which, to date, has significantly muddied our understanding of microRNA localization and biologically relevant function (Kent et al. 2014).”

    From Toward the human cellular microRNAome (2017) · cites this paper as Kent et al. 2014

  • miR-451a and miR-144 are exclusively expressed in red blood cells.

    “Namely, miR-451a and miR-144 are exclusively expressed in red blood cells, yet, because blood is found in all tissues, they have been inappropriately assigned a variety of functions in epithelial and mesenchymal cells based on misinterpreted tissue-level data (Kent et al. 2014; Halushka 2016).”

    From Toward the human cellular microRNAome (2017) · cites this paper as Kent et al. 2014

  • Because blood is found in all tissues, miR-451a and miR-144 have been inappropriately assigned a variety of functions in epithelial and mesenchymal cells based on misinterpreted tissue-level data.

    “yet, because blood is found in all tissues, they have been inappropriately assigned a variety of functions in epithelial and mesenchymal cells based on misinterpreted tissue-level data (Kent et al. 2014; Halushka 2016).”

    From Toward the human cellular microRNAome (2017) · cites this paper as Kent et al. 2014

  • The data matched ground truths about specific microRNA expression in certain cell types, including miR-192 in epithelial cells, miR-126 in endothelial cells and platelets, and miR-9 in brain.

    “Our data matched certain “ground truths” about specific microRNA expression in certain cell types, including miR-192 in epithelial cells, miR-126 in endothelial cells and platelets, and miR-9 in brain (McCall et al. 2011a; Haider et al. 2014; Kent et al. 2014).”

    From Toward the human cellular microRNAome (2017) · cites this paper as Kent et al. 2014

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Authors
Kent, O. A., McCall, M. N., Cornish, T. C., & Halushka, M. K.
Venue
Nucleic Acids Research
Publisher
Oxford University Press (OUP)
Published
2014-05-29
Volume
42
Issue
12
Pages
7528-7538
ISSN
  • 0305-1048
  • 1362-4962
DOI
10.1093/nar/gku461
PMC
PMC4081080
Cited by
187
References
2
Language
en
Licence
creativecommons.org/licenses/by/3.0/ (vor, 859 d)

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