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5′ isomiR variation is of functional and evolutionary importance

Tan, Geok Chin, Chan, Elcie, Molnar, Attila, Sarkar, Rupa, Alexieva, Diana, Isa, Ihsan Mad, Robinson, Sophie, Zhang, Shuchen +11 more·2014·Nucleic Acids Research
DOI 10.1093/nar/gku656PMC PMC4132760
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  • miR-199b-3p (+1 shift), miR-181c-3p (+1 shift), and miR-302a-5p (+3 shift) had highly abundant reads containing a completely different seed sequence than the one currently assigned.

    “This included miR-199b-3p (+1 shift), miR-181c-3p (+1 shift), and miR-302a-5p (+3 shift), all of which had highly abundant reads containing a completely different seed sequence than the one currently assigned, with strong implications for the targeting of genes (Tan et al. 2014).”

    From Toward the human cellular microRNAome (2017) · cites this paper as Tan et al. 2014

  • The signature of 110 DE miRs identified in the AD study showed significant enrichment for neuronal markers.

    “The signature of 110 DE miRs identified in the AD study 64 showed significant enrichment for neuronal markers (Figure 5b).”

    From Human brain microRNAs exhibit cell-type specificity and age dependence (2026) · cites this paper as [64]

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Authors
Tan, G. C., Chan, E., Molnar, A., Sarkar, R., Alexieva, D., Isa, I. M., Robinson, S., Zhang, S., Ellis, P., Langford, C. F., Guillot, P. V., Chandrashekran, A., Fisk, N. M., Castellano, L., Meister, G., Winston, R. M., Cui, W., Baulcombe, D., & Dibb, N. J.
Venue
Nucleic Acids Research
Publisher
Oxford University Press (OUP)
Published
2014-07-23
Volume
42
Issue
14
Pages
9424-9435
ISSN
  • 0305-1048
  • 1362-4962
DOI
10.1093/nar/gku656
PMC
PMC4132760
Cited by
234
References
4
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor, 804 d)

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